would need rifabutin Generic Name: rifabutin (RIF a BUE tin) Brand Name: Mycobutin Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons What is rifabutin? Rifabutin is an antibiotic that fights bacteria. Rifabutin is used to prevent mycobacterium avium complex (MAC) in people with HIV (human immunodeficiency virus) infection. Rifabutin is also used with other medicines to treat tuberculosis in people with HIV. Rifabutin may also be used for purposes not listed in this medication guide. Slideshow HIV & AIDS Update: New Treatments, Easier Options What is the most important information I should know about rifabutin? You should not use rifabutin if you have active tuberculosis, or if you are also taking delavirdine or voriconazole. What should I discuss with my healthcare provider before taking rifabutin? You should not use rifabutin if you are allergic to it, or if you have: active tuberculosis; or if you are allergic to rifapentine or rifampin. Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common. Some medicines can interact with rifabutin and should not be used at the same time. Your doctor may need to change your treatment plan if you take: delavirdine; or voriconazole. To make sure rifabutin is safe for you, tell your doctor if you have: kidney disease; liver disease; or a history of an eye condition called uveitis. This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Rifabutin can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy. It is not known whether rifabutin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take rifabutin? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Rifabutin may be taken with food if it upsets your stomach. If you develop signs of tuberculosis while taking rifabutin, you should be treated with tuberculosis medications right away. Taking only rifabutin while you have active tuberculosis could make the infection resistant to antibiotics. Call your doctor if you have any signs of tuberculosis : fever, cough, night sweats, loss of appetite, weight loss, and feeling constantly tired. While using rifabutin, you may need frequent blood tests and chest x-rays. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Rifabutin will not treat a viral infection such as the flu or a common cold. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking rifabutin? Avoid wearing dentures or contact lenses. Rifabutin may cause certain body fluids to turn red, orange, or brown. This includes tears and saliva. Although this is a harmless side effect, discolored tears or saliva could permanently stain your contact lenses or dentures. Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to. Rifabutin side effects Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; severe eye redness, small white or yellow patches on the surface of your eye; or low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; Common side effects may include: red, orange, or brown discoloration of your skin, tears, sweat, saliva, urine, or stools; gas, burping, upset stomach; rash; or muscle pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Rifabutin dosing information Usual Adult Dose for Mycobacterium avium-intracellulare -- Prophylaxis: 300 mg orally once a day. If nausea of vomiting becomes a problem, rifabutin 150 mg orally every 12 hours is an alternative regimen. Usual Adult Dose for Mycobacterium avium-intracellulare -- Treatment: 300 mg orally once a day. If nausea or vomiting becomes a problem, rifabutin 150 mg orally every 12 hours is an alternative regimen. Therapy often consists of clarithromycin and 2-4 other drugs such as ethambutol, rifampin, clofazimine, and/or other agents. The duration of treatment is generally 18 to 24 months. In immunocompromised patients therapy often consists of clarithromycin or azithromycin and 1 to 3 other drugs such as ethambutol, clofazimine, ciprofloxacin, ofloxacin, rifampin, rifabutin, or amikacin. As long as a clinical and microbiological response is documented, therapy should be continued for life. Usual Adult Dose for Tuberculosis -- Prophylaxis: 300 mg orally once a day. If nausea of vomiting becomes a problem, rifabutin 150 mg orally every 12 hours is an alternative regimen. Rifabutin is recommended by the USPHS/IDSA (U.S. Public Health Service/Infectious Diseases Society of America) Prevention of Opportunistic Infections Working Group as an alternative to rifampin for chemoprophylaxis when exposure to isoniazid-resistant tuberculosis is suspected. For HIV-infected patients, chemoprophylaxis is recommended for those with a positive tuberculin skin test (greater than or equal to 5 mm), prior positive skin test result without treatment, or contact with cases of active tuberculosis. In addition, tuberculin skin test negative, HIV-infected patients from high risk groups or geographic areas with a high prevalence of Mycobacterium tuberculosis may be candidates for chemoprophylaxis. Active tuberculosis should be ruled out prior to initiating preventive therapy. There isn't general agreement on how to use rifabutin for preventive therapy. The decision to use non-isoniazid-containing regimens for chemoprophylaxis should require consultation with public health authorities. Rifabutin is typically administered for 6 months to prevent the development of active tuberculosis in patients with no complicating factors. Patients with complicating factors such as HIV infection, diabetes, hematologic malignancy, or scars on chest X-ray should receive prophylaxis for 12 months. Usual Adult Dose for Tuberculosis -- HIV Positive: 300 mg orally once a day. If nausea of vomiting becomes a problem, rifabutin 150 mg orally every 12 hours is an alternative regimen. Due to the serious public and personal health risk associated with TB, the American Thoracic Society and the Centers for Disease Control strongly recommend giving anti-TB drugs in a directly observed therapy (DOT) program. If daily self-administered therapy is used, many experts strongly recommend use of combination preparations to decrease the chance of medication noncompliance. The duration of therapy depends on the susceptibility of the organism. Pulmonary TB should be treated for a minimum of 6 months. In HIV-positive individuals, some experts believe that therapy should be continued for at least 9 months or 6 months beyond culture conversion. This practice is controversial. The current ATS/CDC recommendations are to treat TB in patients with HIV no differently than in those who are HIV-negative. However, before administering rifampin, providers must take into consideration the important drug-drug interactions that exist between rifampin and the non-nucleoside reverse transcriptase inhibitor and protease inhibitor agents used to treat HIV infection. Rifabutin is a safer agent to use in HIV-infected individuals taking certain antiretroviral agents. In general, six-month regimens are effective if pyrazinamide (PZA) and isoniazid (INH) are included in the first two months of therapy. Recommended regimens are as follows. Rate of INH resistance known to be less than 4%: Daily rifampin (RIF) or rifabutin (RFB) + INH + PZA for 2 months, followed by daily RIF or RFB + INH therapy for 4 months. If susceptibility test confirms INH resistance then follow regimen for INH resistant TB. Rate of INH resistance is greater than or equal to 4% or unknown (and the patient will be compliant): Daily RIF or RFB + INH + PZA + either streptomycin (SM) or ethambutol (ETB) until susceptibility data is available. If no INH resistance, then continue with daily RIF or RFB + INH + PZA for a total of 2 months and finish with RIF or RFB + INH daily to complete 6 months of therapy. If confirmed INH resistance, then follow regimen for INH resistant TB. Rate of INH resistance is greater than or equal to 4% or unknown (and the patient is noncompliant or unreliable): DOT with daily RIF or RFB + INH + PZA + either SM or ETB for 2 weeks then 2 to 3 times a week for 6 weeks. Therapy should then be continued with RIF or RFB + INH 2 to 3 times a week to complete 6 months of therapy. An alternative DOT regimen is RIF or RFB + INH + PZA + either SM or ETB 3 times a week for 6 months. Once susceptibility data is available and INH resistance is confirmed then follow regimen for INH resistant TB. Confirmed INH resistant TB: DOT with daily RIF or RFB + ETB + PZA for 18 months or until sputum is culture negative for at least 12 months. If possible, the treatment of drug-resistant TB should be discussed with an expert in the treatment of such patients. Usual Pediatric Dose for Mycobacterium avium-intracellulare -- Treatment: 5 mg/kg/day orally has been used in a limited number of cases. Used in combination with at least 2 other antimicrobials. Doses of rifabutin may be administered mixed with foods such as applesauce. What other drugs will affect rifabutin? Many drugs can interact with rifabutin. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially: certain antibiotics--clarithromycin, erythromycin, telithromycin; antifungal medicine--fluconazole, itraconazole, posaconazole; hepatitis C medicine--boceprevir, simeprevir, telaprevir; or HIV or AIDS medicine--fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, zidovudine. This list is not complete and many other drugs can interact with rifabutin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. Next Side Effects Print this page Add to My Med List More about rifabutin Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 1 Review Add your own review/rating Drug class: rifamycin derivatives Consumer resources Rifabutin Rifabutin (Advanced Reading) Other brands: Mycobutin Professional resources Rifabutin (AHFS Monograph) Rifabutin (FDA) Rifabutin (Wolters Kluwer) Related treatment guides Mycobacterium avium-intracellulare, Prophylaxis Mycobacterium avium-intracellulare, Treatment Tuberculosis, HIV Positive Tuberculosis, Prophylaxis Where can I get more information? Your pharmacist can provide more information about rifabutin. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 4.01. Date modified: December 03, 2017 Last reviewed: February 26, 2015} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Greenstone LLC Lupin Pharmaceuticals, Inc. Drug Class Rifamycin derivatives Related Drugs Mycobacterium avium-intracellulare, Treatment ciprofloxacin , azithromycin , Zithromax , clarithromycin , More... Tuberculosis, HIV Positive n/a Tuberculosis, Prophylaxis rifampin , isoniazid , bcg , Rifadin , Nydrazid , More... Mycobacterium avium-intracellulare, Prophylaxis azithromycin , Zithromax , clarithromycin , Biaxin , ethambutol , More... Rifabutin Rating 1 User Review 3.0 /10 1 User Review 3.0 Rate it! Rifabutin Images Rifabutin systemic 150 mg (LU R01) View larger images Related Questions & Answers What is the difference between rifampin and rifabutin? Read more questions} } of what's
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