no use [225:300 seconds has been used. 26 During cardiopulmonary bypass, initially, 1 mg/kg by direct IV injection followed by 2.5 mg/kg per hour by continuous IV infusion has been used; 24 if needed, additional direct IV doses of 0.1 0.5 mg/kg have been given to maintain a 2.5-fold or greater prolongation of the baseline ACT. 24 In addition, 50 mg of bivalirudin is added to the recirculating priming fluid of the cardiopulmonary bypass circuit. 24 Special Populations Renal Impairment Reduction of the initial loading dose not necessary in patients with moderate to severe renal impairment. 1 7 Closely monitor ACT in patients with renal impairment. 1 Reduce infusion rate to 1 mg/kg per hour in patients with severe renal impairment (Cl cr] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer The Medicines Company Drug Class Thrombin inhibitors Related Drugs Percutaneous Coronary Intervention Plavix , clopidogrel , bivalirudin , Integrilin , cangrelor , eptifibatide , More... Angina aspirin , amlodipine , carvedilol , metoprolol , atenolol , Norvasc , nitroglycerin , propranolol , Nitrostat , Coreg , More... Angiomax Rating 1 User Review 10 /10 1 User Review 10 Rate it! authentic
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