it is necessary Sodium Acetate Overview Side Effects Professional Interactions Pregnancy More User Reviews Support Group Q & A Pricing & Coupons Pronunciation (SOW dee um AS e tate) Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Solution, Intravenous, as anhydrous: Generic: 2 mEq/mL (20 mL, 50 mL, 100 mL); 4 mEq/mL (50 mL, 100 mL) Slideshow Hives: The What, Where, And Why Of This Bizarre Skin Condition Pharmacologic Category Electrolyte Supplement, Parenteral Use: Labeled Indications Sodium source in large volume IV fluids to prevent or correct hyponatremia in patients with restricted intake; used to counter acidosis through conversion to bicarbonate Contraindications Hypernatremia and fluid retention Dosing: Adult Note: Sodium acetate is metabolized to bicarbonate on an equimolar basis outside the liver; administer in large volume IV fluids as a sodium source. Refer to Sodium Bicarbonate monograph. Maintenance electrolyte requirements of sodium in parenteral nutrition solutions: Daily requirements: 3-4 mEq/kg/24 hours or 25-40 mEq/1000 kcal/24 hours Maximum: 100-150 mEq/24 hours Dosing: Geriatric Refer to adult dosing. Dosing: Pediatric Maintenance electrolyte requirements of sodium in parenteral nutrition solutions: IV: 3-4 mEq/kg/24 hours Dosing: Renal Impairment No dosage adjustment provided in manufacturer s labeling. Use with caution. Dosing: Hepatic Impairment No dosage adjustment provided in manufacturer s labeling. Use with caution. Administration Must be diluted prior to IV administration; infuse hypertonic solutions (eg, >2.8% sodium acetate in sterile water [2.8% sodium acetate in sterile water has osmolarity approximately equivalent to 2% sodium chloride]) via a central line (Mortimer, 2006; Suarez, 2004). If diluted in D 5 W or other solution, the osmolarity may be higher requiring central line administration at a lower sodium acetate concentration. Consult individual institutional policies and procedures. Dietary Considerations Sodium acetate anhydrous (2 mEq/mL): 1 mL = 164 mg sodium acetate anhydrous = 2 mEq of sodium (46 mg) and acetate (118 mg) Storage Store at room temperature of 20 C to 25 C (68 F to 77 F). Drug Interactions There are no known significant interactions. Adverse Reactions 1% to 10%: Cardiovascular: Localized phlebitis, thrombosis Endocrine & metabolic: Electrolyte disturbance (dilution of serum electrolytes), hypernatremia, hypervolemia, hypocalcemia, hypokalemia, metabolic alkalosis, water intoxication Gastrointestinal: Abdominal distention, flatulence Respiratory: Pulmonary edema Warnings/Precautions Concerns related to adverse effects: Hypernatremia: Close monitoring of serum sodium concentrations is needed to avoid hypernatremia. Disease-related concerns: Acid/base disorders: Use with caution in patients with acid/base alterations; contains acetate, monitor closely during acid/base correction. Edema: Use with caution in edematous patients. Heart failure (HF): Use extreme caution in patients with HF; monitor closely for edema. Hepatic impairment: Use with caution in patients with severe hepatic impairment. Renal impairment: Use with caution in patients with renal impairment; monitor serum sodium concentrations closely. Dosage form specific issues: Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register, 2002). See manufacturer s labeling. Other warnings/precautions: Extravasation: Avoid extravasation. Pregnancy Risk Factor C Pregnancy Considerations Animal reproduction studies have not been conducted. Sodium requirements do not change during pregnancy (IOM, 2004). Patient Education Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?) Have patient report immediately to prescriber signs of fluid and electrolyte problems (mood changes, confusion, muscle pain or weakness, abnormal heartbeat, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or nausea or vomiting (HCAHPS). Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients. Next Interactions Print this page Add to My Med List More about sodium acetate Side Effects During Pregnancy Drug Interactions Support Group Pricing & Coupons 0 Reviews Add your own review/rating Drug class: minerals and electrolytes Consumer resources Sodium Acetate Professional resources Sodium Acetate (FDA) Related treatment guides Hyponatremia Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Sodium acetate Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Manufacturers Pfizer Inc. Fresenius Kabi USA, LLC Drug Class Minerals and electrolytes Urinary pH modifiers Related Drugs minerals and electrolytes potassium chloride , calcium carbonate , Caltrate , magnesium oxide , Klor-Con , sodium chloride urinary pH modifiers sodium bicarbonate , potassium citrate , Urocit-K , ammonium chloride Hyponatremia urea , tolvaptan , Samsca , More... it is vital
and carefully Sodium Acetate is incredibly
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