a lot of rolapitant (Oral route) roe-LA-pi-tant Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Varubi Available Dosage Forms: Tablet Therapeutic Class: Antiemetic Pharmacologic Class: Neurokinin-1 Receptor Antagonist Slideshow Cancer Prevention: Live Longer With These Simple Steps Uses For rolapitant Rolapitant is used together with other medicines to prevent delayed nausea and vomiting that is caused by cancer medicines (chemotherapy). Rolapitant is a substance P/neurokinin 1 (NK1) receptor antagonist. It works by blocking the signals to the brain that cause nausea and vomiting. rolapitant is available only with your doctor's prescription. Before Using rolapitant In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rolapitant, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to rolapitant or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of rolapitant in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rolapitant in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rolapitant, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using rolapitant with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Thioridazine Using rolapitant with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Amphetamine Benzphetamine Carbamazepine Dextroamphetamine Digoxin Fosphenytoin Lisdexamfetamine Methamphetamine Nebivolol Netupitant Phenytoin Pimozide Rifampin St John's Wort Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of rolapitant. Make sure you tell your doctor if you have any other medical problems, especially: Liver disease, severe Use with caution. May make this condition worse. Proper Use of rolapitant Take rolapitant exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. rolapitant should come with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions. Take rolapitant with or without food. Dosing The dose of rolapitant will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rolapitant. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For prevention of nausea and vomiting caused by chemotherapy: Adults 180 milligrams (mg) taken 1 to 2 hours before starting cancer treatment. Do not take rolapitant more than one time every 14 days. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of rolapitant, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using rolapitant Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center. Do not take rolapitant if you are also using thioridazine (Mellaril ). Using these medicines together may cause serious unwanted effects . Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. rolapitant Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Black, tarry stools chills cough fever lower back or side pain painful or difficult urination pale skin shortness of breath sore throat ulcers, sores, or white spots in the mouth unusual bleeding or bruising unusual tiredness or weakness Less common Bladder pain bloody or cloudy urine difficult, burning, or painful urination frequent urge to urinate troubled breathing with exertion Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Decreased appetite dizziness Less common Acid or sour stomach belching heartburn hiccups indigestion stomach discomfort, upset, or pain Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. 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Next Side Effects Print this page Add to My Med List More about rolapitant Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 1 Review Add your own review/rating Drug class: NK1 receptor antagonists Consumer resources Rolapitant Other brands: Varubi Professional resources Rolapitant (AHFS Monograph) Rolapitant (Wolters Kluwer) Related treatment guides Nausea/Vomiting, Chemotherapy Induced} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class NK1 receptor antagonists Related Drugs Nausea / Vomiting, Chemotherapy Induced lorazepam , ondansetron , Zofran , Ativan , dexamethasone , metoclopramide , Reglan , Decadron , Marinol , dronabinol , Zofran ODT , Emend , Aloxi , granisetron , Varubi , palonosetron , Kytril , aprepitant , Akynzeo , fosaprepitant , Dexasone , nabilone , More... Rolapitant Rating 1 User Review 10 /10 1 User Review 10 Rate it! 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