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without charge Romycin eent Generic Name: Erythromycin eent Class: Antibacterials CAS Number: 114-07-08 Overview Side Effects Professional Breastfeeding Reviews More Support Group Q & A Introduction Antibacterial; macrolide antibiotic. a b Uses for Romycin Bacterial OphthalmicInfections Treatment of superficial infections of the eye involving the conjunctiva and/or cornea caused by susceptible organisms. a b Concomitant systemic anti-infective therapy may be required, except for very superficial infections. a b Chlamydial Ophthalmic Infections Has been used as an adjunct to oral anti-infective therapy in the treatment of trachoma and inclusion conjunctivitis ; 118 122 127 128 129 130 131 133 134 however, oral azithromycin is the drug of choice for treatment of ocular trachoma caused by Chlamydia trachomatis . 138 Efficacy of topical prophylaxis for the prevention of chlamydial neonatal conjunctivitis has not been established. 101 102 103 104 105 106 107 109 114 116 117 118 135 136 Prophylaxis of Gonococcal Ophthalmia Neonatorum Prophylaxis of gonococcal ophthalmia neonatorum. a b CDC and AAP recommend topical prophylaxis in all neonates as soon as possible after birth; prophylaxis required by law in most states. 117 118 One of several topical agents recommended by CDC and AAP; 117 118 some state or local public health regulations may still require prophylactic use of silver nitrate rather than other anti-infectives. a Efficacy not established in the prevention of ophthalmia caused by penicillinase-producing N. gonorrhoeae . a b Infants born to women with untreated gonorrhea should receive systemic prophylaxis (e.g., ceftriaxone) in addition to topical prophylaxis. 117 118 If gonococcal ophthalmia is diagnosed, systemic therapy (e.g., ceftriaxone) is necessary. 116 117 Slideshow Red, Irritated, Watering Eyes? Chances Are You ve Got Pink Eye Romycin Dosage and Administration Administration Ophthalmic Administration Apply topically to the eye as an ointment. a b Avoid contamination of the tip of the ointment tube. a b Following placement of ointment in neonate s lower conjunctival sacs, massage gently to spread ointment; wipe away excess ointment with sterile cotton after 1 minute. a Do not flush ointment from the eye following application. b Use a new tube or single-use container of ointment for each neonate. b Dosage Pediatric Patients Bacterial Ophthalmic Infections Ophthalmic Apply 1-cm ribbon of 0.5% ointment to the infected eye(s) up to 6 times daily. a b Chlamydial Ophthalmic Infections Trachoma Ophthalmic Apply a small amount of 0.5% ointment to each eye twice daily for 2 months or twice daily for the first 5 days of each month for 6 months. 118 Prophylaxis of Gonococcal Ophthalmia Neonatorum Ophthalmic Place a 1-cm ribbon of 0.5% ointment in the lower conjunctival sacs of both eyes shortly after birth. a b Adults Bacterial Ophthalmic Infections Ophthalmic Apply a 1-cm ribbon of 0.5% ointment to the infected eye(s) up to 6 times daily. a b Chlamydial Infections Trachoma Ophthalmic Apply a small amount of 0.5% ointment to each eye twice daily for 2 months or twice daily for the first 5 days of each month for 6 months. 118 Cautions for Romycin Contraindications Hypersensitivity to erythromycin or any ingredient in the formulation. a b Warnings/Precautions Sensitivity Reactions Sensitivity Possible sensitivity reactions. a b General Precautions Superinfection Possible emergence and overgrowth of nonsusceptible organisms, including fungi. a b Discontinue drug and institute appropriate therapy if superinfection occurs. a b Specific Populations Pregnancy Category B. b Lactation Caution advised in nursing women. b Pediatric Use See Uses. Common Adverse Effects Minor ocular irritation, redness, hypersensitivity. a b Romycin Pharmacokinetics Absorption Extent Topical application probably does not produce significant antibacterial concentrations in deep layers of the cornea or in the aqueous humor. a Not known whether erythromycin is absorbed to any substantial extent from mucous membranes. a Stability Storage Ophthalmic Ointment 15 30 C. b Actions and Spectrum Usually bacteriostatic; may be bactericidal in high concentrations or against highly susceptible organisms. a Inhibits protein synthesis in susceptible organisms by binding to 50S ribosomal subunits. a b Most effective against gram-positive cocci (staphylococci and streptococci) and gram-positive bacilli; also effective against some gram-negative cocci ( Neisseria species) and some gram-negative bacilli (including some strains of Haemophilus influenzae and Moraxella lacunata ). a b Also active against Chlamydia . a b Advice to Patients Importance of not contaminating the tip of the ointment tube. a b Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs. a b Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. Importance of informing patients of other important precautionary information. (See Cautions.) Preparations Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name Erythromycin Routes Dosage Forms Strengths Brand Names Manufacturer Ophthalmic Ointment 0.5%* Erythromycin Ophthalmic Ointment Akorn, Bausch & Lomb, Fougera Romycin OCuSOFT AHFS DI Essentials. Copyright 2017, Selected Revisions July 1, 2006. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. Use is not currently included in the labeling approved by the US Food and Drug Administration. References Only references cited for selected revisions after 1984 are available electronically. 101. Anon. Neonatal gonococcal ophthalmia California. MMWR Morb Mortal Wkly Rep . 1983; 32:518-9. [PubMed 6412066] 102. Zola EM. Evaluation of drugs used in the prophylaxis of neonatal conjunctivitis. Drug Intell Clin Pharm . 1984; 18:692-6. [PubMed 6383753] 103. Hammerschlag MR, Chandler JW, Alexander ER et al. Erythromycin ointment for ocular prophylaxis of neonatal chlamydial infection. JAMA . 1980; 244:2291-3. [PubMed 7431552] 104. Rettig PJ, Patamasucon P, Siegel JD. Postnatal prophylaxis of chlamydial conjunctivitis. JAMA . 1981; 246: 2321-2. [PubMed 7299949] 105. Anon. Antibiotic-resistant strains of Neisseria gonorrhoeae . Policy guidelines for detection, management, and control. MMWR Morb Mortal Wkly Rep . 1987; 36(Suppl 5):15-6S. 106. Dillon HC Jr. Prevention of gonococcal ophthalmia neonatorum. N Engl J Med . 1986; 315:1414-5. [PubMed 3773967] 107. Sandstrom I. Ophthalmia neonatorum with special reference to Chlamydia trachomatis : diagnosis and treatment. Acta Paediatr Scand . 1986; 330:3-27. 109. Hammerschlag MR. Neonatal ocular prophylaxis. Pediatr Infect Dis J . 1988; 7:81-2. [PubMed 3344174] 114. Fransen L, Klauss V. Neonatal ophthalmia in the developing world: epidemiology, etiology, management and control. Int Ophthalmol . 1988; 11:189-96. [PubMed 3047073] 116. Bell TA, Sandstrom KI, Gravett MG et al. Comparison of ophthalmic silver nitrate solution and erythromycin ointment for prevention of natally acquired Chlamydia trachomatis . Sex Transm Dis . 1987; 14:195-200. [PubMed 3438783] 117. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines 2002. MMWR Morb Mortal Wkly Rep . 2002; 51(No. RR-6):1-78. 118. Committee on Infectious Diseases, American Academy of Pediatrics. Report of the Committee on Infectious Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2000:208-12,735,741. 120. Benson JW, Davidson DC. Neonatal chlamydia conjunctivitis. Br Med J . 1978; 2:961. [PubMed 709165] 121. Ridgway GL, Oriel JD. Treatment of neonatal inclusion blenorrhea. N Engl J Med . 1977; 297:512. [PubMed 887138] 122. Rowe DS, Aicardi EZ, Dawson CR et al. Purulent ocular discharge in neonates: significance of chlamydia trachomatis. Pediatrics . 1979; 63:628-32. [PubMed 440875] 123. Schachter J. Chlamydial infections (third of three parts). N Engl J Med . 1978; 298:540-9. [PubMed 342952] 124. Moore RA, Schmitt BD. Conjunctivitis in children. Clin Ped . 1979; 18:26-30. 125. Lorian V. Antibiotics in laboratory medicine. Baltimore, MD: Williams and Wilkins; 1980:419, 471. 126. Ridgway GL. Chlamydial infections in pediatrics. Arch Dis Child . 1978; 53:447-8. [PubMed 356747] 127. Roy FH. Trachoma. Ann Ophthalmol . 1974; 6:1167-71. [PubMed 4429322] 128. Vastine DW, Dawson CR, Daghfous T et al. Severe endemic trachoma in Tunisia: I. Effect of topical chemotherapy on conjunctivitis and ocular bacteria. Br J Ophthalmol . 1974; 58:833-42. [PubMed 4451650] 129. Maichuk YF. Some aspects of rational trachoma therapy. Am J Ophthalmol . 1972; 74:684-703. 130. Dawson CR, Daghfous T, Whitcher J et al. Intermittent trachoma chemotherapy: a controlled trial of topical tetracycline or erythromycin. Bull World Health Organ . 1981; 59:91-7. [PubMed 7020973] 131. Dawson CR, Daghfous T, Messadi M et al. Severe endemic trachoma in Tunisia. II. A controlled therapy trial of topically applied chlortetracycline and erythromycin. Arch Ophthalmol . 1974; 92:198-203. [PubMed 4137188] 132. Dawson C. Therapy of diseases caused by Chlamydia organisms. Int Ophthalmol Clin . 1973; 13:93-101. [PubMed 4593599] 133. Whitcher JP, Dawson CR, Messadi M et al. Severe endemic trachoma in Tunisia: changes in ocular bacterial pathogens in children treated by the intermittent antibiotic regimen. Rev Int Trach . 1974; 51:49-58. [PubMed 4157128] 134. Dawson CR, Schachter J. Strategies for treatment and control of blinding trachoma: cost-effectiveness of topical or systemic antibiotics. Rev Infect Dis . 1985; 7:768-73. [PubMed 4070912] 135. Anon. Drugs for sexually transmitted diseases. Med Lett Drugs Ther. 1999; 41:85-90. 136. Hammerschlag MR, Cummings C, Roblin PM et al. Efficacy of neonatal ocular prophylaxis for the prevention of chlamydial and gonococcal conjunctivitis. N Engl J Med . 1989; 320:769-72. [PubMed 2922026] 137. Thylefors B. Azithromycin. A new opportunity for control of trachoma. WHO Drug Information . 1996; 10:132-3. 138. Anon. The choice of antibacterial drugs. Med Lett Drugs Ther . 2001; 43:69-78. [PubMed 11518876] a. AHFS Drug Information 2003. McEvoy, GK, ed. Erythromycin (ophthalmic ointment). Bethesda, MD: American Society of Health-System Pharmacists; 2598-9. b. Dista (Eli Lilly). Ilotycin (erythromycin) ophthalmic ointment prescribing information. In: Physicians desk reference. 55th ed. Montvale, NJ: Medical Economics Company Inc; 2001:1123-4. Next Breastfeeding Warnings Print this page Add to My Med List More about Roymicin (erythromycin ophthalmic) Side Effects Breastfeeding Support Group En Español 0 Reviews Add your own review/rating Drug class: ophthalmic anti-infectives Consumer resources Roymicin Romycin Romycin (Advanced Reading) Professional resources Erythromycin eent (AHFS Monograph) Erythromycin Ophthalmic Ointment (FDA) Other brands: Ilotycin Related treatment guides Conjunctivitis, Bacterial} Antibiotics 101 Everything you need to know about antibiotics: List of Common Antibiotics & Types Antibiotics & Drinking Alcohol - Is it Safe? Antibiotics For UTI - What Are My Options? FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Drug Class Ophthalmic anti-infectives Related Drugs Conjunctivitis, Bacterial azithromycin ophthalmic , ciprofloxacin ophthalmic , levofloxacin ophthalmic , erythromycin ophthalmic , gentamicin ophthalmic , tobramycin ophthalmic , Vigamox , bacitracin ophthalmic , moxifloxacin ophthalmic , TobraDex , Maxitrol , Polytrim , Besivance , gatifloxacin ophthalmic , Ciloxan , Tobrex , Ocuflox , Lincocin , Azasite , Zymaxid , Gentak , Blephamide , lincomycin , More... Roymicin Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first!} } the most effective


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