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in an effort to enzalutamide (Oral route) en-za-LOO-ta-mide Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Xtandi Available Dosage Forms: Capsule, Liquid Filled Therapeutic Class: Antineoplastic Agent Slideshow 15 Prostate Cancer Facts You Simply Can't Ignore Uses For enzalutamide Enzalutamide is used to treat metastatic (cancer that has spread) prostate cancer. It works to stop the growth of cancer cells by blocking the effects of androgen hormones (eg, testosterone). Enzalutamide is an antiandrogen cancer medicine. enzalutamide is available only with your doctor's prescription. Before Using enzalutamide In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For enzalutamide, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to enzalutamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of enzalutamide in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of enzalutamide in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking enzalutamide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using enzalutamide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Artemether Atazanavir Boceprevir Daclatasvir Dasabuvir Delamanid Elbasvir Grazoprevir Isavuconazonium Lumefantrine Lurasidone Maraviroc Using enzalutamide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Alfentanil Apremilast Aprepitant Aripiprazole Axitinib Bedaquiline Bosentan Bosutinib Brigatinib Cabozantinib Carbamazepine Ceritinib Clarithromycin Clozapine Cobimetinib Conivaptan Crizotinib Cyclosporine Deferasirox Deflazacort Desogestrel Dexamethasone Dienogest Dihydroergotamine Dolutegravir Doxorubicin Doxorubicin Hydrochloride Liposome Drospirenone Efavirenz Eliglustat Ergotamine Erlotinib Estradiol Ethinyl Estradiol Ethynodiol Etonogestrel Etravirine Everolimus Exemestane Fentanyl Fosaprepitant Fosphenytoin Gemfibrozil Gestodene Ibrutinib Idelalisib Imatinib Indinavir Ivabradine Ixazomib Ketoconazole Levonorgestrel Linagliptin Lopinavir Macitentan Manidipine Mephenytoin Mestranol Methadone Midostaurin Modafinil Naloxegol Nefazodone Nelfinavir Netupitant Nevirapine Nifedipine Nilotinib Norethindrone Norgestimate Norgestrel Olaparib Osimertinib Oxcarbazepine Oxycodone Palbociclib Panobinostat Pazopanib Perampanel Phenytoin Pimozide Piperaquine Pixantrone Ponatinib Posaconazole Quetiapine Quinidine Regorafenib Ribociclib Rifabutin Rifampin Rifapentine Ritonavir Romidepsin Saquinavir Sirolimus Sorafenib St John's Wort Tacrolimus Tasimelteon Telaprevir Telithromycin Temsirolimus Thiotepa Ticagrelor Tofacitinib Ulipristal Valbenazine Vandetanib Velpatasvir Vemurafenib Venetoclax Vilazodone Vinflunine Vorapaxar Voriconazole Vortioxetine Warfarin Using enzalutamide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aripiprazole Lauroxil Ospemifene Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of enzalutamide. Make sure you tell your doctor if you have any other medical problems, especially: Brain injury, history of or Brain tumor, history of or Seizures, history of or Stroke, history of or Transient ischemic attack, recent Use with caution. May cause side effects to become worse. Proper Use of enzalutamide Take enzalutamide only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. enzalutamide comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions. Take your medicine at the same time each day with or without food. Swallow the capsule whole. Do not chew, dissolve, or open it. If you are taking 2 cancer medicines, follow your doctor's instructions on when to take them. Dosing The dose of enzalutamide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of enzalutamide. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (capsules): For prostate cancer: Adults 160 milligrams (mg) (four 40 mg capsules) once a day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of enzalutamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using enzalutamide It is very important that your doctor check your progress at regular visits to make sure enzalutamide is working properly and to check for unwanted effects. Women should not use enzalutamide, especially women who are pregnant or able to become pregnant. enzalutamide can harm an unborn baby. It can also cause birth defects if the father is using it when his sexual partner becomes pregnant. You must use a condom together with a second effective form of birth control during therapy and for 3 months after the last dose. If a pregnancy occurs while you are using enzalutamide, tell your doctor right away. enzalutamide may cause dizziness, tiredness, muscle weakness, or seizures (very rare). Avoid driving, using machines, or doing anything else that could be dangerous until you know how enzalutamide affects you . enzalutamide may cause a neurological disorder called posterior reversible encephalopathy syndrome (PRES). Check with your doctor right away if you have seizures, headache, confusion, unusual drowsiness, dullness, tiredness, weakness, feeling of sluggishness, or blurred vision. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. enzalutamide Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Back pain bloating or swelling of the face, arms, hands, lower legs, or feet blood in the urine blurred vision chest pain cough with mucus difficulty with breathing dizziness fever or chills loss of bladder or bowel control nervousness painful or difficult urination pounding in the ears slow or fast heartbeat sore throat tingling of the hands or feet unable to move the legs unusual weight gain or loss Less common Anxiety confusion or excitement depression fainting falling lightheadedness loss of memory memory or attention span problems nightmares or vivid dreams rapid, shallow breathing Rare Seizures Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Body aches or pain bone pain burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings diarrhea difficulty having a bowel movement (stool) difficulty with moving dry throat ear congestion feeling of constant movement of self or surroundings feeling of warmth hoarseness joint pain lack or loss of strength loss of voice muscle pain, stiffness, or weakness pain or tenderness around the eyes and cheekbones redness of the face, neck, arms, and upper chest sensation of spinning stuffy or runny nose tender, swollen glands in the neck trouble sleeping trouble with swallowing unusual tiredness or weakness Less common Bloody nose dry skin frequent urination itching skin pale-colored urine Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about enzalutamide Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 4 Reviews Add your own review/rating Drug class: antiandrogens Consumer resources Enzalutamide Other brands: Xtandi Professional resources Enzalutamide (AHFS Monograph) Enzalutamide (Wolters Kluwer) Related treatment guides Prostate Cancer} Drug Status Rx Availability Prescription only X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antiandrogens Hormones / antineoplastics Related Drugs Prostate Cancer estradiol , Premarin , Estrace , bicalutamide , Casodex , Eligard , Xtandi , Zytiga , leuprolide , Taxotere , Lupron Depot , conjugated estrogens , docetaxel , Firmagon , Trelstar , Zoladex , abiraterone , degarelix , Menest , flutamide , flax , Delestrogen , Xofigo , More... Enzalutamide Rating 4 User Reviews 1.0 /10 4 User Reviews 1.0 Rate it! Help and Support Looking for answers? Ask a question or go join the enzalutamide support group to connect with others who have similar interests.} } sporting events


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