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high-quality cobicistat (Oral route) koe-BIK-i-stat Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Tybost Available Dosage Forms: Tablet Therapeutic Class: Anti-Infective Agent Slideshow 10 Serious Infections That Will Make You Shudder Uses For cobicistat Cobicistat is used to increase the effects of atazanavir or darunavir for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). cobicistat is available only with your doctor's prescription. Before Using cobicistat In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cobicistat, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to cobicistat or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of cobicistat in the pediatric population. Safety and efficacy have not been established. Geriatric Although appropriate studies on the relationship of age to the effects of cobicistat have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking cobicistat, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using cobicistat with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Alfuzosin Carbamazepine Cisapride Colchicine Conivaptan Crizotinib Dihydroergotamine Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Eletriptan Eliglustat Eplerenone Ergonovine Ergotamine Fosphenytoin Isavuconazonium Sulfate Ivabradine Lomitapide Lovastatin Lurasidone Maraviroc Methylergonovine Midazolam Naloxegol Pazopanib Phenobarbital Phenytoin Pimozide Primidone Ranolazine Rifampin Riociguat Romidepsin Sildenafil Silodosin Simvastatin St John's Wort Tolvaptan Triazolam Venetoclax Using cobicistat with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Ado-Trastuzumab Emtansine Afatinib Alprazolam Amiodarone Amprenavir Apixaban Aprepitant Aripiprazole Avanafil Bedaquiline Betrixaban Boceprevir Bosentan Bosutinib Brigatinib Bromocriptine Budesonide Cabazitaxel Cabozantinib Calcifediol Cariprazine Ceritinib Cilostazol Clarithromycin Cobimetinib Cyclophosphamide Cyclosporine Dabrafenib Daclatasvir Dasatinib Deflazacort Delamanid Delavirdine Dexamethasone Diazepam Digoxin Disopyramide Docetaxel Domperidone Donepezil Erlotinib Erythromycin Eslicarbazepine Acetate Eszopiclone Etravirine Everolimus Fentanyl Flecainide Fluoxetine Fluticasone Fosamprenavir Fosaprepitant Haloperidol Hydrocortisone Ibrutinib Idelalisib Ifosfamide Iloperidone Irinotecan Irinotecan Liposome Itraconazole Ivacaftor Ketoconazole Lapatinib Levomilnacipran Lidocaine Lopinavir Macitentan Manidipine Methadone Mexiletine Midostaurin Mifepristone Morphine Morphine Sulfate Liposome Netupitant Nevirapine Nifedipine Nilotinib Nimodipine Nisoldipine Olaparib Orlistat Oxcarbazepine Oxycodone Palbociclib Panobinostat Pimavanserin Piperaquine Pixantrone Ponatinib Propafenone Quetiapine Quinidine Reboxetine Regorafenib Retapamulin Ribociclib Rifabutin Rifapentine Ritonavir Rivaroxaban Rosuvastatin Ruxolitinib Salmeterol Saquinavir Simeprevir Sirolimus Sunitinib Suvorexant Tacrolimus Tadalafil Tamoxifen Tamsulosin Telithromycin Temsirolimus Thiotepa Ticagrelor Tipranavir Topotecan Toremifene Trabectedin Tramadol Trazodone Valbenazine Vardenafil Vemurafenib Vilanterol Vilazodone Vinblastine Vincristine Vincristine Sulfate Liposome Vinflunine Vorapaxar Voriconazole Warfarin Zolpidem Using cobicistat with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aripiprazole Lauroxil Atazanavir Darunavir Indinavir Nelfinavir Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of cobicistat. Make sure you tell your doctor if you have any other medical problems, especially: Kidney disease Use with caution. May make this condition worse. Proper Use of cobicistat Take cobicistat exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. cobicistat comes with a patient information leaflet. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. You should talk to your doctor if you have any questions. cobicistat should be taken with food. Do not change the dose or stop using cobicistat without checking first with your doctor . When your supply of cobicistat is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of cobicistat. If you are also taking an antacid containing aluminum or magnesium, take it at least 2 hours before or after cobicistat with atazanavir. Ask your doctor or pharmacist before taking any other medicines for your stomach or heartburn. Dosing The dose of cobicistat will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of cobicistat. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For enhancement of atazanavir or darunavir: Adults 150 milligrams (mg) once a day, taken with atazanavir 300 mg once a day or darunavir 800 mg once a day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of cobicistat, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose of cobicistat with atazanavir or darunavir by less than 12 hours , take the missed dose of cobicistat with atazanavir or darunavir right away. However, if you miss a dose of cobicistat with atazanavir or darunavir by more than 12 hours , wait and take the next dose at your usual time. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Do not use cobicistat if the seal on the bottle is broken or missing. Keep the bottle tightly closed. Keep the medicine in the original bottle that you were given at the pharmacy. Precautions While Using cobicistat Your doctor will want to check your progress at regular visits , especially during the first few weeks that you take cobicistat. Blood and urine tests may be needed to check for any unwanted effects. Do not use cobicistat together with atazanavir or darunavir if you are also using any of the following: alfuzosin (Uroxatral ), carbamazepine (Tegretol ), cisapride (Propulsid ), colchicine (Colcrys ), dronedarone (Multaq ), indinavir (Crixivan ), irinotecan (Camptosar ), lovastatin (Altoprev , Mevacor ), lurasidone (Latuda ), midazolam (Versed ), nevirapine (Viramune ), phenobarbital (Luminal ), phenytoin (Dilantin ), pimozide (Orap ), ranolazine (Ranexa ), rifampin (Rifadin ), sildenafil (Revatio ), simvastatin (Simcor , Zocor ), St. John's wort, triazolam (Halcion ), or ergot medicines (eg, dihydroergotamine, ergotamine, methylergonovine, Cafergot , Migranal ). Doing so may cause serious unwanted effects. Using cobicistat together with tenofovir DF may cause kidney problems (including Fanconi syndrome). Tell your doctor right away if you have bloody urine, decreased frequency or amount of urine, increased thirst, loss of appetite, lower back or side pain, nausea, vomiting, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, or weight gain. cobicistat does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contaminated blood. Make sure you understand and practice safe sex, even if your partner also has HIV. Avoid sharing needles with anyone. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. cobicistat Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Abdominal or stomach pain bloody urine chills clay-colored stools dark urine decreased frequency or amount of urine dizziness fast heartbeat fever headache hives or welts, itching, or rash hoarseness increased thirst irritation joint pain, stiffness, or swelling loss of appetite lower back or side pain nausea and vomiting pain in the groin or genitals redness of the skin sharp back pain just below the ribs swelling of the eyelids, face, lips, hands, lower legs, or feet tightness in the chest troubled breathing or swallowing unpleasant breath odor unusual tiredness or weakness vomiting of blood weight gain yellow eyes or skin Less common or rare Dark-colored urine muscle cramps or spasms muscle pain or stiffness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common or rare Diarrhea discouragement feeling sad or empty irritability loss of interest or pleasure trouble concentrating trouble sleeping upper abdominal or stomach pain Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about cobicistat Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: antiviral boosters Consumer resources Cobicistat Other brands: Tybost Professional resources Cobicistat (AHFS Monograph) Cobicistat (Wolters Kluwer) Related treatment guides HIV Infection} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antiviral boosters Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , abacavir , tenofovir , Reyataz , Epzicom , ritonavir , Complera , emtricitabine , darunavir , Kaletra , Intelence , Sustiva , Epivir , efavirenz , nevirapine , atazanavir , raltegravir , Selzentry , More... Cobicistat Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the cobicistat support group to connect with others who have similar interests.} } you ought to be


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