incredible cobicistat Generic Name: cobicistat (koe BIK i stat) Brand Name: Tybost Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A What is cobicistat? Cobicistat reduces the action of enzymes in your liver that break down certain antiviral medicines. This allows the antiviral medicines to be used more safely and effectively at lower doses. Cobicistat is given together with atazanavir (Reyataz) or darunavir (Prezista) to treat human immunodeficiency virus (HIV) in adults. HIV is the virus that causes acquired immunodeficiency syndrome (AIDS). Cobicistat is not an antiviral medicine and will not treat HIV or AIDS. Cobicistat is given only to help increase your blood levels of atazanavir or darunavir. Cobicistat may also be used for purposes not listed in this medication guide. Slideshow HIV & AIDS Update: New Treatments, Easier Options What is the most important information I should know about cobicistat? Cobicistat is not a complete treatment and must be used in combination with other antiviral medicines your doctor has prescribed. However, there are certain antiviral medicines that should not be taken in combination with cobicistat. Follow your doctor's medication and dosing instructions very carefully. Cobicistat is recommended for use only with atazanavir or darunavir. You should not take cobicistat with other protease inhibitor HIV medicines, such as fosamprenavir, nelfinavir, saquinavir, or tipranavir. You should not take cobicistat with darunavir if you are taking darunavir twice daily. You should not take cobicistat with atazanavir if you also take indinavir, irinotecan, or nevirapine. Many drugs can interact with cobicistat and some should not be used at the same time. Tell your doctor about all your current medicines and any you start or stop using. What should I discuss with my healthcare provider before taking cobicistat? Cobicistat is not a complete treatment and must be used in combination with other antiviral medicines your doctor has prescribed. However, there are certain antiviral medicines that should not be taken in combination with cobicistat. Follow your doctor's medication and dosing instructions very carefully. You should not take cobicistat if you are allergic to it. You should not take cobicistat with atazanavir if you also take: indinavir, irinotecan, nevirapine, or birth control pills that contain drospirenone and ethinyl estradiol (Beyaz, Sayfral, Yasmin, Yaz). You should not take cobicistat with atazanavir or darunavir if you also take: alfuzosin; cisapride; colchicine; dronedarone; lovastatin or simvastatin; oral midazolam, or triazolam; ranolazine; rifampin; sildenafil (Revatio, for treating pulmonary arterial hypertension); St. John's wort; antipsychotic medicine--lurasidone, pimozide; ergot medicine--dihydroergotamine, ergotamine, methylergonovine; or seizure medication--carbamazepine, phenobarbital, phenytoin. To make sure cobicistat is safe for you, tell your doctor if you have: liver disease; or kidney disease. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. Cobicistat is not approved for use by anyone younger than 18 years old. How should I take cobicistat? Cobicistat is usually taken once per day with atazanavir or darunavir. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take your HIV medicines with food at the same time each day to be sure you do not miss a dose. If you take cobicistat with atazanavir, your doctor may also prescribe a medicine to reduce stomach acid. If so, follow these recommendations, unless your doctor tells you otherwise: If you take an antacid: Take the antacid at least 2 hours before or 2 hours after you take cobicistat and atazanavir. If you take a medicine such as cimetidine, ranitidine, Tagamet, Axid, Zantac, Pepcid, and others: You may either take the stomach medicine at the same time you take cobicistat and atazanavir; or wait at least 10 hours after taking the stomach medicine to take your cobicistat and atazanavir doses. If you take a proton pump inhibitor such as omeprazole, esomeprazole, Nexium, Prevacid, Prilosec, Protonix: Wait at least 12 hours after taking the stomach medicine to take your cobicistat and atazanavir doses. While using cobicistat, your blood may need to be tested often. Your kidney function may also need to be tested. HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor. Store in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. To avoid missing a dose, get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking cobicistat? Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Cobicistat side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common side effects may include: nausea; or jaundice. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Cobicistat dosing information Usual Adult Dose for HIV Infection: 150 mg orally once a day with food Comments: -This drug must be used with atazanavir or darunavir; the manufacturer product information for these agents should be consulted. -This drug may be used with atazanavir (300 mg orally once a day) in therapy-naive and therapy-experienced patients. -This drug may be used with darunavir (800 mg orally once a day) in therapy-naive patients and therapy-experienced patients with no darunavir resistance associated substitutions. -This drug is not interchangeable with ritonavir and should not be used with darunavir 600 mg twice a day, fosamprenavir, saquinavir, or tipranavir. Use: To increase systemic exposure of atazanavir or darunavir in combination with other antiretrovirals in the treatment of HIV-1 infection What other drugs will affect cobicistat? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with cobicistat, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about cobicistat Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: antiviral boosters Consumer resources Cobicistat Cobicistat (Advanced Reading) Other brands: Tybost Professional resources Cobicistat (AHFS Monograph) Cobicistat (Wolters Kluwer) Related treatment guides HIV Infection Where can I get more information? Your pharmacist can provide more information about cobicistat. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Date modified: December 03, 2017 Last reviewed: September 25, 2017} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antiviral boosters Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , abacavir , tenofovir , Reyataz , Epzicom , ritonavir , Complera , emtricitabine , darunavir , Kaletra , Intelence , Sustiva , Epivir , efavirenz , nevirapine , atazanavir , raltegravir , Selzentry , More... Cobicistat Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the cobicistat support group to connect with others who have similar interests.} } it is usually
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Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, Cobicistat
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