beneficial properties element siltuximab (Intravenous route) sil-TUX-i-mab Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Sylvant Available Dosage Forms: Powder for Solution Pharmacologic Class: Monoclonal Antibody Slideshow Insomnia and Sleep Deprivation: The Case For A Good Night's Sleep Uses For siltuximab Siltuximab injection is used to treat a rare blood disorder called multicentric Castleman's disease (MCD). siltuximab is used in patients who do not have human immunodeficiency virus (HIV) and human herpes virus-8 (HHV-8) infection. siltuximab is to be given only by or under the direct supervision of your doctor. Before Using siltuximab In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For siltuximab, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to siltuximab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of siltuximab injection in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of siltuximab injection in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of siltuximab. Make sure you tell your doctor if you have any other medical problems, especially: Stomach or bowel problems (eg, diverticulitis, ulcers) Use with caution. May increase risk for gastrointestinal perforation. Infection, severe May decrease your body's ability to fight infection. It must be treated first before using siltuximab. Proper Use of siltuximab A nurse or other trained health professional will give you siltuximab in a hospital. siltuximab is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 1 hour. siltuximab comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. Precautions While Using siltuximab If you will be using siltuximab for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by siltuximab. Blood tests may be needed to check for unwanted effects. Make sure your doctor knows if you are pregnant or planning to become pregnant. You must use an effective form of birth control to keep from getting pregnant during therapy and for 3 months after the last dose of siltuximab. Your body's ability to fight infection may be reduced while you are using siltuximab. It is very important that you call your doctor at the first sign of any infection. Check with your doctor right away if you have any of the following symptoms while receiving siltuximab: a fever, chills, cough, flu-like symptoms, or unusual tiredness or weakness. While you are being treated with siltuximab, do not have any immunizations (vaccines) without your doctor's approval. Live virus vaccines should not be given with siltuximab or soon after you receive it. siltuximab may cause a serious allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving siltuximab. Siltuximab may cause an infusion reaction while you are receiving it or right after the infusion ends. Check with your doctor or nurse right away if you have back pain, chest pain or discomfort, fast or uneven heartbeat, nausea or vomiting, trouble breathing, or redness of the face, neck, arms, and upper chest. siltuximab may increase your risk of gastrointestinal perforation. Tell your doctor right away if you have any of the following symptoms: severe abdominal or stomach pain or cramps, bloody, black, or tarry stools, or vomiting of material that looks like coffee grounds. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. siltuximab Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Abdominal or stomach pain black, tarry stools bleeding gums bloating or swelling of the face, arms, hands, lower legs, or feet bloody urine blurred vision body aches or pain chills confusion cough decreased frequency or amount of urine difficulty with breathing dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position ear congestion fever full or bloated feeling headache increased thirst loss of appetite loss of voice lower back or side pain nasal congestion nausea pinpoint red spots on the skin pressure in the stomach rapid weight gain runny nose sneezing sore throat sweating swelling of the abdominal or stomach area tingling of the hands or feet troubled breathing unusual bleeding or bruising unusual tiredness or weakness unusual weight gain or loss vomiting Less common Back pain chest pain or discomfort dizziness dry mouth fainting fast, irregular, pounding, or racing heartbeat or pulse feeling of warmth flushing or redness of the skin lightheadedness rapid breathing redness of the face, neck, arms, and occasionally, upper chest sunken eyes unusually warm skin wrinkled skin Rare Difficulty with swallowing hives, itching, or skin rash puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue tightness in the chest Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Difficulty having a bowel movement (stool) difficulty with moving joint pain, stiffness, or swelling muscle pain or stiffness rash with flat lesions or small raised lesions on the skin Less common Darkening of the skin decreased appetite dry skin skin rash, encrusted, scaly, and oozing Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about siltuximab Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: interleukin inhibitors Consumer resources Siltuximab Other brands: Sylvant Professional resources Siltuximab (AHFS Monograph) Siltuximab (Wolters Kluwer) Related treatment guides Multicentric Castleman s Disease} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Interleukin inhibitors Related Drugs Multicentric Castleman s Disease Sylvant , siltuximab , More... Siltuximab Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the siltuximab support group to connect with others who have similar interests.} } work from home
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