likely Opdivo Generic Name: nivolumab (nye VOL ue mab) Brand Name: Opdivo Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Compare Alternatives Pricing & Coupons What is nivolumab? Nivolumab is a cancer medicine that works with your immune system to interfere with the growth and spread of cancer cells in the body. Nivolumab is used to treat certain types of cancer, including melanoma (skin cancer), non-small cell lung cancer, bladder cancer, kidney cancer, squamous cell cancer of the head and neck, colorectal cancer, and classical Hodgkin Lymphoma. Nivolumab can be given alone or in combination with other cancer medicines. Nivolumab is often used after other medicines have been tried without success. Nivolumab is sometimes used if the cancer has spread to other parts of the body. For some types of cancer, nivolumab is given when the cancer cannot be treated with surgery. For Hodgkin lymphoma, nivolumab is used if the condition has relapsed or progressed after stem cell transplant and treatment with brentixumab vedotin (Adcetris). In people with non-small cell lung cancer, nivolumab may increase the chance of a longer survival time. Nivolumab was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis for some types of cancer. In clinical studies, nivolumab produced complete or partial responses, or longer survival time without progression of the cancer. However, further studies are needed. Nivolumab may also be used for purposes not listed in this medication guide. Slideshow Cancer Prevention: Live Longer With These Simple Steps What is the most important information I should know about nivolumab? Nivolumab can change the way your immune system works, which may cause certain side effects that can lead to serious medical problems. Call your doctor at once if you have: chest pain, cough, shortness of breath, vision changes, tiredness, severe muscle pain or weakness, diarrhea and severe stomach pain, blood in your stools, little or no urinating, swelling in your feet, bruising or bleeding, dark urine, yellowing of the skin or eyes, skin sores or blisters, confusion, hallucinations, a seizure, or a hormonal disorder (frequent headaches, feeling light-headed, increased thirst or urination, a deeper voice, feeling cold, weight gain or loss). The side effects of nivolumab can cause symptoms in many different parts of your body. Some side effects may need to be treated with other medicine, and your cancer treatments may be delayed. You will need frequent medical tests to help your doctor determine if it is safe for you to keep receiving nivolumab. What should I discuss with my healthcare provider before receiving nivolumab? You should not use nivolumab if you are allergic to it. To make sure nivolumab is safe for you, tell your doctor if you have ever had: lung disease or breathing problems; liver disease; kidney disease; a thyroid disorder; an autoimmune disorder such as lupus, Crohn's disease, or ulcerative colitis; or an organ transplant. Do not use nivolumab if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 5 months after your last dose. It is not known whether nivolumab passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How is nivolumab given? Before you start treatment, your doctor will perform tests to make sure nivolumab is the best treatment for your type of cancer. Nivolumab is injected into a vein through an IV. A healthcare provider will give you this injection. Nivolumab is usually given once every 2 to 3 weeks. Your doctor will determine how long to treat you with this medicine. Nivolumab must be given slowly. The IV infusion can take at least 1 hour to complete. You may be given medication to treat or prevent certain side effects of nivolumab. Nivolumab can cause certain side effects by changing the way your immune system works. These side effects can cause symptoms in many different parts of your body. Some side effects may need to be treated with other medicine, and your cancer treatments may be delayed or stopped altogether. You will need frequent medical tests to help your doctor determine if it is safe for you to keep receiving nivolumab. Do not miss any follow-up visits to your doctor. What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your nivolumab injection. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while receiving nivolumab? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Nivolumab side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, short of breath, itchy, tingly, chilled, or feverish. Call your doctor at once if you have: severe or ongoing diarrhea, severe stomach pain, bloody or tarry stools; new or worsening skin rash, itching, or blistering; sores or ulcers in your mouth, nose, rectum, or genitals; changes in your vision; severe muscle weakness, ongoing pain in your muscles or joints; lung problems--new or worsening cough, sudden chest pain or discomfort, wheezing, feeling short of breath; symptoms of brain swelling--confusion, headache, memory problems, hallucinations, neck stiffness, drowsiness, seizure (convulsions); kidney problems--little or no urinating; blood in your urine; swelling in your feet or ankles; liver problems--severe nausea or vomiting, loss of appetite, upper stomach pain, drowsiness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or signs of a hormonal disorder--frequent or unusual headaches, feeling light-headed or very tired, mood or behavior changes, increased thirst or urination, constipation, hair loss, sweating, hoarse or deepened voice, feeling cold, weight gain, or weight loss. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: nausea, vomiting, loss of appetite, diarrhea, constipation; feeling weak, tired, or short of breath; cold symptoms such as runny or stuffy nose, sneezing, cough, sore throat; fever, body aches; skin rash, itching; or back pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect nivolumab? Other drugs may interact with nivolumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about Opdivo (nivolumab) Side Effects During Pregnancy Dosage Information Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Español 17 Reviews Add your own review/rating Drug class: Anti-PD-1 monoclonal antibodies Consumer resources Opdivo Opdivo (Advanced Reading) Professional resources Opdivo (AHFS Monograph) Opdivo (FDA) Related treatment guides Non-Small Cell Lung Cancer Renal Cell Carcinoma Head and Neck Cancer Melanoma, Metastatic ... +5 more Where can I get more information? Your pharmacist can provide more information about nivolumab. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01. Date modified: December 03, 2017 Last reviewed: August 09, 2017} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Bristol-Myers Squibb Company Drug Class Anti-PD-1 monoclonal antibodies Related Drugs Non-Small Cell Lung Cancer Avastin , methotrexate , Taxol , cisplatin , Taxotere , Tarceva , More... Renal Cell Carcinoma Avastin , nivolumab , Nexavar , Afinitor , Sutent , bevacizumab , More... Melanoma, Metastatic Keytruda , nivolumab , pembrolizumab , Yervoy , ipilimumab , Tafinlar , More... Hepatocellular Carcinoma nivolumab , Nexavar , Stivarga , sorafenib , regorafenib , More... 5 more conditions... Opdivo Rating 17 User Reviews 3.6 /10 17 User Reviews 3.6 Rate it! Related Questions & Answers Once treatment starts with opdivo, has anyone had an alcoholic drink such as vodka/tonic? Opdivo - what about severe rashes-mom is calling it a vaginal yeast infection? Is Opdivo considered chemotherapy? Do care takers have to take precautions as they do with chemo? Opdivo - How to treat severe itching all over the body? My husband has been on Opdivo since November 2015, in the last six months he has lots of pain in his Read more questions} } best
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