could nts with mild to moderate renal impairment and was similar to that of patients with normal renal function. Table 12: Mean (SD) Daptomycin Population Pharmacokinetic Parameters Following Infusion of Cubicin 4 mg/kg or 6 mg/kg to Infected Adult Patients and Noninfected Adult Subjects with Various Degrees of Renal Function Renal Function Pharmacokinetic Parameters * t 1/2 (h) 4 mg/kg V ss (L/kg) 4 mg/kg CL T (mL/h/kg) 4 mg/kg AUC 0- (mcg h/mL) 4 mg/kg AUC ss (mcg h/mL) 6 mg/kg C min everyone

could nts with mild to moderate renal impairment and was similar to that of patients with normal renal function. Table 12: Mean (SD) Daptomycin Population Pharmacokinetic Parameters Following Infusion of Cubicin 4 mg/kg or 6 mg/kg to Infected Adult Patients and Noninfected Adult Subjects with Various Degrees of Renal Function Renal Function Pharmacokinetic Parameters * t 1/2 (h) 4 mg/kg V ss (L/kg) 4 mg/kg CL T (mL/h/kg) 4 mg/kg AUC 0- (mcg h/mL) 4 mg/kg AUC ss (mcg h/mL) 6 mg/kg C min everyone

May 30, 2016
weighing machine nts with mild to moderate renal impairment and was similar to that of patients with normal renal function. Table 12: Mean (SD) Daptomycin Population Pharmacokinetic Parameters Following Infusion of Cubicin 4 mg/kg or 6 mg/kg to Infected Adult Patients and Noninfected Adult Subjects with Various Degrees of Renal Function Renal Function Pharmacokinetic Parameters * t 1/2 (h) 4 mg/kg V ss (L/kg) 4 mg/kg CL T (mL/h/kg) 4 mg/kg AUC 0- (mcg h/mL) 4 mg/kg AUC ss (mcg h/mL) 6 mg/kg C min even if
 
Photo :nts with mild to moderate renal impairment and was similar to that of patients with normal renal function. Table 12: Mean (SD) Daptomycin Population Pharmacokinetic Parameters Following Infusion of Cubicin 4 mg/kg or 6 mg/kg to Infected Adult Patients and Noninfected Adult Subjects with Various Degrees of Renal Function Renal Function Pharmacokinetic Parameters * t 1/2 (h) 4 mg/kg V ss (L/kg) 4 mg/kg CL T (mL/h/kg) 4 mg/kg AUC 0- (mcg h/mL) 4 mg/kg AUC ss (mcg h/mL) 6 mg/kg C min

rental ss (mcg/mL) 6 mg/kg Note: Cubicin was administered over a 30-minute period. * CL CR that provide


portraits nts with mild to moderate renal impairment and was similar to that of patients with normal renal function. Table 12: Mean (SD) Daptomycin Population Pharmacokinetic Parameters Following Infusion of Cubicin 4 mg/kg or 6 mg/kg to Infected Adult Patients and Noninfected Adult Subjects with Various Degrees of Renal Function Renal Function Pharmacokinetic Parameters * t 1/2 (h) 4 mg/kg V ss (L/kg) 4 mg/kg CL T (mL/h/kg) 4 mg/kg AUC 0- (mcg h/mL) 4 mg/kg AUC ss (mcg h/mL) 6 mg/kg C min personalize


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