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political opinions eflornithine (Injection route) ef-LOR-ni-theen Pharmacologic Class: Ornithine Decarboxylase Inhibitor Uses For eflornithine Eflornithine is used to treat African sleeping sickness, a disease caused by protozoa (tiny one-celled animals). Eflornithine is available only with your doctor's prescription. Slideshow Hives: The What, Where, And Why Of This Bizarre Skin Condition Before Using eflornithine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For eflornithine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to eflornithine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Studies on eflornithine have been done only in adult patients, and there is no specific information comparing use of eflornithine in children with use in other age groups. Geriatric Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of eflornithine in the elderly with use in other age groups. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of eflornithine. Make sure you tell your doctor if you have any other medical problems, especially: Anemia or other blood problems Eflornithine may cause blood problems, making the problems you already have worse Hearing loss Long-term treatment with eflornithine may increase your chance of hearing loss Kidney disease Patients with kidney disease may have an increased chance of side effects Proper Use of eflornithine To ensure the best response, eflornithine must be given for the full time of treatment. Also, eflornithine works best when there is a constant amount in the blood. To help keep the amount constant, eflornithine must be given on a regular schedule. Dosing The dose of eflornithine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of eflornithine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For injection dosage form: For the treatment of African sleeping sickness: Adults Dose is based on body weight and must be determined by your doctor. The usual dose is 100 milligrams (mg) per kilogram (kg) (45 mg per pound) of body weight injected slowly into a vein over a period of at least forty-five minutes. This dose is given every six hours for fourteen days. Children Use and dose must be determined by your doctor. Precautions While Using eflornithine It is very important that your doctor check your progress at regular visits. eflornithine may cause blood problems. Eflornithine can lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take to reduce the risk of infection or bleeding: Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills. Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. eflornithine Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Sore throat and fever unusual bleeding or bruising unusual tiredness or weakness Rare Convulsions (seizures) loss of hearing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea nausea stomach pain vomiting Rare Hair loss headache Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about eflornithine topical Side Effects During Pregnancy Dosage Information Support Group En EspaƱol 58 Reviews Add your own review/rating Drug class: miscellaneous topical agents Consumer resources Eflornithine topical Eflornithine Eflornithine Topical (Advanced Reading) Other brands: Vaniqa Professional resources Eflornithine (AHFS Monograph) Related treatment guides Hirsutism} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Miscellaneous topical agents Related Drugs Hirsutism spironolactone , Aldactone , Vaniqa , flutamide , eflornithine topical , Eulexin , More... Eflornithine topical Rating 58 User Reviews 8.1 /10 58 User Reviews 8.1 Rate it! Help and Support Looking for answers? 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