lifelike Anti-Diarrheal Side Effects Generic Name: loperamide Side Effects Dosage Professional Interactions Pregnancy More Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Note: This document contains side effect information about loperamide. Some of the dosage forms listed on this page may not apply to the brand name Anti-Diarrheal. For the Consumer Applies to loperamide: oral capsule, oral capsule liquid filled, oral liquid, oral solution, oral suspension, oral tablet, oral tablet chewable Along with its needed effects, loperamide (the active ingredient contained in Anti-Diarrheal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking loperamide: Rare Bloating constipation loss of appetite stomach pain (severe) with nausea and vomiting Check with your doctor as soon as possible if any of the following side effects occur while taking loperamide: Rare Skin rash Some side effects of loperamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Rare Dizziness or drowsiness dryness of mouth For Healthcare Professionals Applies to loperamide: compounding powder, oral capsule, oral liquid, oral suspension, oral tablet, oral tablet chewable Gastrointestinal Necrotizing enterocolitis with perforation was reported in two women following short courses (24 hours and 3 days) of loperamide (the active ingredient contained in Anti-Diarrheal) for the treatment of acute diarrhea with fever. Resected bowel in both cases revealed extensive mucosal hemorrhage and necrosis. Toxic megacolon has been reported in association with the use of loperamide to treat symptoms of ulcerative colitis and pseudomembranous colitis due to antibiotic therapy. In one patient treated for ulcerative colitis, abdominal symptoms seemed to improve in the days before requiring emergency laparotomy. Loperamide has also been implicated in a case of appendicitis. A 35-year-old male self-treated traveler's diarrhea with loperamide at greater than the recommended daily dose for seven days. Three days later, an appendalith was noted during an emergency appendectomy. The authors speculated that fecal stasis induced by loperamide increases the risk of fecalith and appendalith formation, the latter being associated with the pathogenesis of appendicitis. Gastrointestinal side effects reported during loperamide therapy are often likely due to the underlying illness and include nausea, vomiting, dyspepsia, abdominal cramps, and anorexia. Cases of paralytic ileus associated with abdominal distention have been reported rarely. Many of these reports had occurred in a setting with acute dysentery, overdose, and children less than 2-years-old. [ Ref ] Gastrointestinal side effects have included nausea, vomiting, dyspepsia, abdominal cramps, anorexia, abdominal pain, abdominal distention, dry mouth, abdominal discomfort, and constipation. Gastrointestinal side effects have rarely included ileus, toxic megacolon and necrotizing enterocolitis, with or without perforation. [ Ref ] Nervous system Severe central nervous system depression may occur with overdose. [ Ref ] Nervous system side effects have rarely included drowsiness, tiredness, dizziness and severe central nervous system depression. [ Ref ] Other While structurally related to meperidine and diphenoxylate, abuse potential is very low with loperamide (the active ingredient contained in Anti-Diarrheal) At therapeutic doses, it does not produce euphoria. In opioid addicted monkeys, loperamide in high doses did prevent withdrawal symptoms. A 26-year-old male with a history of opioid and alcohol abuse, began taking loperamide for the treatment of acute diarrhea. Despite denying euphoric effects from the drug, he gradually increased his intake to 320 mg per day. Attempts to stop the drug resulted in acute withdrawal (chest pain, shortness of breath, chills, diaphoresis, abdominal discomfort, nausea, and vomiting). Methadone relieved the symptoms. A slow methadone taper in an inpatient setting was successful in treating the physical dependence. [ Ref ] Other side effects have rarely included physical dependence. [ Ref ] Hypersensitivity Hypersensitivity side effects have included skin rash. Anaphylactic shock and anaphylactoid reactions have been reported rarely. [ Ref ] Dermatologic Dermatologic side effects have included rash, pruritus, urticaria, and angioedema. Bullous eruptions including erythema multiforme, Stevens-Johnson syndrome, and Toxic Epidermal Necrolysis (TEN) have been reported rarely. [ Ref ] Genitourinary Genitourinary side effects have included urinary retention. [ Ref ] References 1. Walley T, Milson D "Loperamide related toxic megacolon in Clostridium difficile colitis." Postgrad Med J 66 (1990): 582 2. Brown JW "Toxic megacolon associated with loperamide therapy." JAMA 241 (1979): 501-2 3. "Product Information. Imodium (loperamide)." Janssen Pharmaceutica, Titusville, NJ. 4. Ericsson CD, Johnson PC "Safety and efficacy of loperamide." Am J Med 88 (1990): s10-4 5. Olm M, Gonzalez FJ, Garcia-Valdecasas JC, Fuster J, Bertran A, Milla J "Necrotising colitis with perforation in diarrhoic patients treated with loperamide." Eur J Clin Pharmacol 40 (1991): 415-6 6. Katz JP, Sturmann KM "Appendicitis associated with loperamide hydrochloride abuse." Ann Pharmacother 27 (1993): 369-70 7. Hill MA, Greason FC "Loperamide dependence." J Clin Psychiatry 53 (1992): 450 Some side effects of Anti-Diarrheal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA . Next Dosage Print this page More about Anti-Diarrheal (loperamide) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group 2 Reviews Add your own review/rating Drug class: antidiarrheals Consumer resources Other brands: Imodium , Imodium A-D , Diamode , Imotil , Kao-Paverin Professional resources Good Neighbor Anti-Diarrheal (FDA) ... +5 more Related treatment guides Diarrhea Diarrhea, Chronic Diarrhea, Acute Traveler's Diarrhea Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Drug Status Rx OTC Availability Rx and/or OTC C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Antidiarrheals Related Drugs Traveler's Diarrhea ciprofloxacin , Bactrim , sulfamethoxazole / trimethoprim , loperamide , Imodium , More... Diarrhea, Chronic loperamide , Imodium , Pepto-Bismol , bismuth subsalicylate , Imodium A-D , Kaopectate , More... Diarrhea, Acute loperamide , Imodium , Imodium A-D , loperamide / simethicone , Diamode , atropine / difenoxin , More... Diarrhea loperamide , Lomotil , Imodium , Acidophilus , atropine / diphenoxylate , neomycin , More... Anti-Diarrheal Rating 2 User Reviews 8.7 /10 2 User Reviews 8.7 Rate it! Anti-Diarrheal Images Anti-Diarrheal loperamide 2 mg (122 ) View all images at present
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