in the dark Ryzolt (Oral) Generic Name: tramadol (Oral route) TRAM-a-dol Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Oral route(Tablet) Tramadol hydrochloride has the potential for addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk before prescribing, and monitor for development of these behaviors or conditions. Serious, life-threatening, or fatal respiratory depression may occur. Monitor closely, especially upon initiation or following a dose increase. Accidental ingestion of tramadol hydrochloride, especially in children, can result in fatal overdose of tramadol hydrochloride. Prolonged use of tramadol hydrochloride during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available. Concomitant use or discontinuation of concomitantly used cytochrome P450 3A4 and cytochrome P450 2D6 inhibitors may effect the plasma levels of tramadol and its active metabolite M1 and lead to fatal respiratory depression, profound sedation, opioid toxicity, and/or opioid withdrawal. Monitor patients carefully when tramadol hydrochloride and cytochrome P450 3A4 and cytochrome P450 2D6 inhibitors are concurrently used. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for patients with inadequate alternative treatment options. Limit dosages and durations to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation . Commonly used brand name(s) In the U.S. ConZip FusePaq Synapryn Rybix ODT Ryzolt Ultram Ultram ER Available Dosage Forms: Tablet, Extended Release Suspension Capsule, Extended Release Tablet, Disintegrating Tablet Therapeutic Class: Analgesic Chemical Class: Opioid Slideshow Fighting the Fight: Fibromyalgia Explained Uses For Ryzolt Tramadol is used to relieve moderate to moderately severe pain, including pain after surgery. The extended-release or long-acting tablets are used for chronic ongoing pain. Tramadol belongs to the group of medicines called opioid analgesics. It acts in the central nervous system (CNS) to relieve pain. When tramadol is used for a long time, it may become habit-forming (causing mental or physical dependence). Physical dependence may lead to side effects when you stop taking the medicine. This medicine is available only with your doctor's prescription. Before Using Ryzolt In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of Rybix ODT, Ryzolt , and Ultram tablets in children younger than 16 years of age. Safety and efficacy have not been established. Appropriate studies have not been performed on the relationship of age to the effects of Ultram ER extended-release tablets in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tramadol in the elderly. However, elderly patients are more likely to have unwanted side effects (eg, constipation, lightheadedness, dizziness, or fainting, stomach upset, weakness) and age-related liver, kidney, heart, or lung problems, which may require caution and an adjustment in the dose for patients receiving tramadol. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Furazolidone Iproniazid Isocarboxazid Linezolid Methylene Blue Moclobemide Nalmefene Naltrexone Nialamide Phenelzine Procarbazine Rasagiline Safinamide Selegiline Tranylcypromine Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acepromazine Alfentanil Almotriptan Alprazolam Amineptine Amisulpride Amitriptyline Amitriptylinoxide Amobarbital Amoxapine Amphetamine Anileridine Aripiprazole Asenapine Baclofen Benperidol Benzphetamine Bromazepam Bromopride Bromperidol Brompheniramine Buprenorphine Bupropion Buspirone Butabarbital Butorphanol Carbamazepine Carbinoxamine Carisoprodol Carphenazine Ceritinib Chloral Hydrate Chlordiazepoxide Chlorpheniramine Chlorpromazine Chlorzoxazone Citalopram Clarithromycin Clobazam Clomipramine Clonazepam Clorazepate Clozapine Cobicistat Cocaine Codeine Cyclobenzaprine Darunavir Desipramine Desmopressin Desvenlafaxine Dexmedetomidine Dextroamphetamine Dextromethorphan Dezocine Diazepam Dibenzepin Dichloralphenazone Difenoxin Dihydrocodeine Diphenhydramine Diphenoxylate Dolasetron Donepezil Dothiepin Doxepin Doxylamine Droperidol Duloxetine Eletriptan Enflurane Escitalopram Estazolam Eszopiclone Ethchlorvynol Ethopropazine Ethylmorphine Fentanyl Flibanserin Fluconazole Fluoxetine Fluphenazine Flurazepam Fluspirilene Fluvoxamine Fospropofol Frovatriptan Granisetron Halazepam Haloperidol Halothane Hexobarbital Hydrocodone Hydromorphone Hydroxytryptophan Hydroxyzine Idelalisib Imipramine Isoflurane Ketamine Ketazolam Ketobemidone Levomilnacipran Levorphanol Lisdexamfetamine Lithium Lofepramine Lorazepam Lorcaserin Loxapine Meclizine Melitracen Melperone Meperidine Mephobarbital Meprobamate Meptazinol Mesoridazine Metaxalone Methadone Methamphetamine Methocarbamol Methohexital Methotrimeprazine Metoclopramide Midazolam Milnacipran Mirabegron Mirtazapine Molindone Moricizine Morphine Morphine Sulfate Liposome Nalbuphine Naratriptan Nefazodone Nicomorphine Nitrazepam Nitrous Oxide Nortriptyline Olanzapine Ondansetron Opipramol Opium Opium Alkaloids Orphenadrine Oxazepam Oxycodone Oxymorphone Palonosetron Papaveretum Paregoric Paroxetine Peginterferon Alfa-2b Pentazocine Pentobarbital Perampanel Periciazine Perphenazine Phenobarbital Pimozide Piperacetazine Pipotiazine Piritramide Prazepam Primidone Prochlorperazine Promethazine Propofol Protriptyline Quazepam Quetiapine Ramelteon Remifentanil Remoxipride Rizatriptan Secobarbital Sertindole Sertraline Sibutramine Sodium Oxybate St John's Wort Sufentanil Sulpiride Sumatriptan Suvorexant Tapentadol Temazepam Thiethylperazine Thiopental Thiopropazate Thioridazine Tianeptine Tilidine Tizanidine Tolonium Chloride Topiramate Trazodone Triazolam Trifluoperazine Trifluperidol Triflupromazine Trimeprazine Trimipramine Tryptophan Venlafaxine Vilazodone Vortioxetine Zaleplon Ziprasidone Zolmitriptan Zolpidem Zopiclone Zotepine Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Quinidine Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Ethanol Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse, history of or Brain tumor or Depression, history of or Drug abuse or dependence, history of or Gallstones or Head injury or Hormonal problems or Increased pressure in the head or Infections of the central nervous system (CNS) or Lung or breathing problems (eg, COPD, cor pulmonale, hypercapnia, hypoxia) or Mental illness, history of or Phenylketone allergy, history of or Seizures or epilepsy, history of or Stomach problems, severe Use with caution. The chance of serious side effects may be increased. Breathing or lung problems (eg, asthma, hypercapnia, respiratory depression), severe or Stomach or bowel blockage (eg, paralytic ileus) Should not be used in patients with this condition. Kidney disease or Liver disease (including cirrhosis) Use with caution. The effects may be increased because of slower removal of the medicine from the body. Phenylketonuria (PKU) The orally disintegrating tablet contains phenylalanine, which can make this condition worse. Proper Use of tramadol This section provides information on the proper use of a number of products that contain tramadol. It may not be specific to Ryzolt. Please read with care. Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions. If you think that this medicine is not working as well after you have been taking it for a few weeks, do not increase the dose. Instead, check with your doctor. If you are using the disintegrating tablet , make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Do not break, crush, or chew it. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, swallow or take a sip of water. Swallow the extended-release tablet and tablet whole with liquids. Do not break, crush, or chew it. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For chronic pain: For oral dosage form (extended-release tablets): Adults At first, 100 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 300 mg per day. Children Use and dose must be determined by your doctor. For moderate to severe pain: For oral dosage form (disintegrating tablets): Adults and children 16 years of age and older At first, 50 to 100 milligrams (mg) every four to six hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 400 mg per day. Children younger than 16 years of age Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and children 16 years of age and older At first, 25 milligrams (mg) per day, taken every morning. Your doctor may increase your dose as needed. However, the dose is usually not more than 400 mg per day. Children younger than 16 years of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Ryzolt It is very important that your doctor check your progress at regular visits to make sure the medicine is working properly and to check for any unwanted effects. Do not use this medicine if you are using or have used an MAO inhibitor (eg, Eldepryl , Marplan , Nardil , or Parnate ) within the past 14 days. Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS) . The use of alcohol or other medicines that affect the CNS with (drug) may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn babies. Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed or have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure your caregiver knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Tell your doctor if you have any sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let your doctor know if you or anyone in your family has bipolar disorder (manic-depressive disorder) or has tried to commit suicide. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, swelling of your hands, face, or mouth, or chest pain while you are using this medicine. This medicine may cause some people to become drowsy, dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert . Make sure your doctor knows if you are pregnant, may be pregnant, or planning to become pregnant. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Before having any kind of surgery (including dental surgery) or emergency treatment, tell the doctor or dentist in charge that you are taking this medicine. Taking tramadol together with medicines that are used during surgery or dental or emergency treatments may cause increased side effects. If you think you or someone else may have taken an overdose of tramadol, get emergency help at once. Signs of an overdose include convulsions (seizures), difficult or troubled breathing, irregular, fast or slow, or shallow breathing, pale or blue lips, fingernails, or skin, pinpoint pupils of the eyes, or trouble breathing. Do not stop suddenly taking this medicine without first checking with your doctor . Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as anxiety, diarrhea, headache, nausea, shivering, sweating, tremors, or trouble with sleeping. Using too much of this medicine may cause infertility (unable to have children). Talk with your doctor before using this medicine if you plan to have children. Ryzolt Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common or rare Abdominal or stomach fullness abnormal or decreased touch sensation blisters under the skin bloating blood in the urine blood pressure increased blurred vision change in walking and balance chest pain or discomfort chills convulsions (seizures) darkened urine difficult urination dizziness or lightheadedness when getting up from a lying or sitting position fainting fast heartbeat frequent urge to urinate gaseous abdominal or stomach pain indigestion irregular heartbeat loss of memory numbness and tingling of the face, fingers, or toes numbness, tingling, pain, or weakness in the hands or feet pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion pain or discomfort in the arms, jaw, back, or neck pains in the stomach, side, or abdomen, possibly radiating to the back pale bluish-colored or cold hands or feet recurrent fever seeing, hearing, or feeling things that are not there severe cramping severe nausea severe redness, swelling, and itching of the skin sweats trembling and shaking of the hands or feet trouble performing routine tasks weak or absent pulses in the legs yellow eyes or skin Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Change in consciousness decreased awareness or responsiveness difficulty with breathing lack of muscle tone lightheadedness loss of consciousness pinpointed pupils of the eyes severe sleepiness slow or irregular heartbeat unusual tiredness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain agitation constipation cough diarrhea discouragement drowsiness dry mouth feeling of warmth feeling sad or empty feeling unusually cold fever general feeling of discomfort or illness headache heartburn irritability itching or skin rash joint pain loss of appetite loss of interest or pleasure loss of strength or weakness muscle aches and pains nausea redness of the face, neck, arms, and occasionally, upper chest restlessness runny nose shivering sleepiness or unusual drowsiness sore throat stuffy nose sweating tiredness trouble concentrating unusual feeling of excitement weakness Less common or rare Abnormal dreams appetite decreased back pain bladder pain blistering, crusting, irritation, itching, or reddening of the skin bloody or cloudy urine body aches or pain change in hearing clamminess cold flu-like symptoms confusion cough producing mucus cracked, dry, or scaly skin decreased interest in sexual intercourse difficult, burning, or painful urination difficulty with moving disturbance in attention ear congestion ear drainage earache or pain in ear excessive gas fall false or unusual sense of well-being feeling hot feeling jittery flushing or redness of the skin general feeling of bodily discomfort goosebumps headache, severe and throbbing hoarseness hot flashes inability to have or keep an erection itching, pain, redness, swelling, tenderness, or warmth on the skin joint sprain joint stiffness joint swelling loss in sexual ability, desire, drive, or performance loss of voice lower back or side pain muscle aching or cramping muscle injury muscle pain or stiffness muscle spasms or twitching nasal congestion neck pain night sweats pain pain in the limbs pain or tenderness around the eyes and cheekbones pain, swelling, or redness in the joints skin discoloration swelling swelling of the hands, ankles, feet, or lower legs tightness of the chest trouble in holding or releasing urine trouble with sleeping weight increased or decreased Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about Ryzolt (tramadol) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group 11 Reviews Add your own review/rating Drug class: narcotic analgesics Consumer resources Ryzolt Other brands: Ultram , Ultram ER , ConZip , Rybix ODT Professional resources Ryzolt (FDA) Tramadol Hydrochloride (AHFS Monograph) Related treatment guides Back Pain Chronic Pain Pain} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out 4 CSA Schedule Some potential for abuse Approval History Drug history at FDA Drug Class Narcotic analgesics Related Drugs Back Pain tramadol , naproxen , Cymbalta , aspirin , ibuprofen , Norco , duloxetine , More... Chronic Pain tramadol , oxycodone , Cymbalta , duloxetine , Percocet , morphine , fentanyl , More... Pain tramadol , acetaminophen , Tylenol , naproxen , oxycodone , aspirin , ibuprofen , More... Ryzolt Rating 11 User Reviews 6.2 /10 11 User Reviews 6.2 Rate it! Ryzolt Images Ryzolt tramadol hydrochloride extended-release 100 mg (PP 100 ) View all images Related Questions & Answers Oxycodone - Can someone help me please? My doc gave me a med called RYZOLT. Could you please tell me What is Ryzolt( tramadol HCI ) Any side effects that are bad? Is there a difference between the Ryzolt& the generic tramadol? I need a generic for Ryzolt 100. It's over $90.00 with insurance!? Latest test results show my esophogus is nerve damaged - anyone else has this and what helped? Read more questions} } person who
to admit Ryzolt (Oral) all of the sudden
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