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recommended Desquam-X Wash Generic Name: benzoyl peroxide Dosage Form: topical solution Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Pricing & Coupons Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here. WATER BASE Desquam-X 5 Wash (5% benzoyl peroxide) WATER BASE Desquam-X 10 Wash (10% benzoyl peroxide) Rx only Desquam-X Wash Description DESQUAM-X 5 (5% benzoyl peroxide) and DESQUAM-X 10 (10% benzoyl peroxide) brand topical therapeutic anti-acne cleansers contains benzoyl peroxide (5% and 10% respectively) in a lathering water base of sodium octoxynol- 3 sulfonate, dioctyl sodium sulfo-succinate, magnesium aluminum silicate, methylcellulose and EDTA. Molecular structure Slideshow Newborn Baby Health: 8 Woes From Cradle Cap And Colic To Whooping Cough Desquam-X Wash - Clinical Pharmacology The effectiveness of benzoyl peroxide in the treatment of acne vulgaris is primarily attributable to its antibacterial activity, especially with respect to Propionibacterium acnes , the predominant organism in sebaceous follicles and comedones. 1,2 The antibacterial activity of this compound is presumably due to the release of active or free-radical oxygen capable of oxidizing bacterial proteins. 3 In acne patients treated topically with benzoyl peroxide, resolution of the acne usually coincides with reduction in the levels of P. acnes and free fatty acids (FFA). Mild desquamation is another observed action of topically applied benzoyl peroxide and may also play a role in the drug s effectiveness in acne. 3 Studies also indicate that topical benzoyl peroxide may exert a se-bostatic effect with a resultant reduction of skin surface lipids. 4,5 Benzoyl peroxide has been shown to be absorbed by the skin, where it is metabolized to benzoic acid and then excreted as benzoate in the urine. 6 Indications and Usage for Desquam-X Wash DESQUAM-X 5 and DESQUAM-X 10 Wash are indicated for the topical treatment of mild to moderate acne. In more severe cases, it may be used as an adjunct in therapeutic regimens including benzoyl peroxide gels, antibiotics, retinoic acid products and sulfur/salicylic acid-containing preparations. The improvement of the treated condition is dependent on the degree and type of acne, the frequency of use of Desquam-X Wash and the nature of other therapies employed. Contraindications This product should not be used in patients known to be sensitive to benzoyl peroxide or any other of the listed ingredients. Precautions General: Avoid contact with eyes and other mucous membranes. For external use only. In patients known to be sensitive to the following substances, there is a possibility of cross-sensitization: benzoic acid derivatives (including certain topical anesthetics) and cinnamon. Information for Patients: This product may bleach colored fabric or hair. Concurent use with PABA-containing sunscreens may result in transient discoloration of the skin. Carcinogenesis, Mutagenesis, Impairment of Fertility: Based upon considerable evidence, benzoyl peroxide is not considered to be a carcinogen. However, in one study, using mice known to be highly susceptible to cancer, there was evidence for benzoyl peroxide as a tumor promoter. Benzoyl peroxide has been found to be inactive as a mutagen in the Ames Salmonella and other assays, including the mouse dominant lethal assay. This assay is frequently used to assess the effect of substances on spermatogenesis. Pregnancy (Category C): Animal reproduction studies have not been conducted with benzoyl peroxide (Desquam-X Wash). It is also not known whether benzoyl peroxide can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Benzoyl peroxide should be given to a pregnant woman only if clearly needed. Nursing Mothers: It is not known whether this drug is excreted in human milk. Caution should be exercised when benzoyl peroxide is administered to a nursing woman. Pediatric Use: Safety and effectiveness in children below the age of 12 have not been established. Adverse Reactions Adverse reactions which may be encountered with topical benzoyl peroxide include excessive drying (manifested by marked peeling, erythema and possible edema), and allergic contact sensitization. Excessive dryness would appear to occur in approximately 2 patients in 50. Pertinent literature would seem to indicate that allergic sensitization to benzoyl peroxide may occur in 10 to 25 patients in 1,000. 7,8,9 There is one reference that reports an occurrence of sensitization in 5 of 100 patients. 10 Overdosage In the event that excessive scaling, erythema or edema occur, the use of this preparation should be discontinued. If the reaction is judged to be due to excessive use and not allergenicity, after symptoms and signs subside, a reduced dosage schedule may be cautiously tried. To hasten resolution of the adverse effects, emollients, cool compresses and/or topical corticosteroid preparations may be used. Desquam-X Wash Dosage and Administration Shake well before use. Wash affected areas once or twice daily, avoiding contact with eyes or mucous membranes. Wet skin areas to be treated prior to administration; apply Desquam-X Wash, work to a full lather, rinse thoroughly and pat dry. The amount of drying or peeling may be controlled by modification of dose frequency or drug concentration. How is Desquam-X Wash Supplied Desquam-X Wash (5%): 5 oz. plastic bottle, NDC 10631-284-05. Desquam-X Wash (10%): 5 oz. plastic bottle, NDC 10631-285-05. Store at controlled room temperature (59 -86 F; 15 -30 C). REFERENCES Kligman AM, Leyden JJ, Stewart R: New uses for benzoyl peroxide: A broad-spectrum antimicrobial agent. Int J Derm 16:413-417, 1977. Leyden JJ, Stewart R, Kligman AM: Updated in vivo methods for evaluating topical antimicrobial agents on human skin. J Invest Dermatol 72:165-170, 1979. Fulton JE, Farzad-Bakshandeh A, Bradley S: Studies on the mechanism of action of topical benzoyl peroxide and vitamin-A acid in acne vulgaris. J Cut Path 1:191-200, 1974. Fanta D, Jurecka W: Autora-diographic investigation on benzoyl peroxide treated skin. Acta Dermatovener 58:361-362, 1978. Fanta D, Muller MM: Effect of benzoyl peroxide on skin surface lipids. Dermatologica 158:55-59, 1979. Nacht S, Yeung D, Beasley J, Anjo M, Maibach HI: Benzoyl peroxide in vitro and in vivo skin penetration and metabolic disposition. Presented to Soc for Invest Derm, June 9-14, 1979. Amsterdam. Eaglstein WH: Allergic contact dermatitis to benzoyl peroxide. Arch Dermatol 97:527, 1968. Pace WE: A benzoyl peroxide-sulfur cream for acne vulgaris. Canad Med Assoc J 93:252-253, 1965. Vasarinsh P: Benzoyl peroxide-sulfur lotions in acne vulgaris a controlled study. Cutis 5(1):65-69, 1969. Fanta D: Clinical and experimental studies with benzoyl peroxide in the treatment of acne. Hautzart 29:481- 486, 1978. RANBAXY Jacksonville, FL 32257 USA Revised June 2008 PACKAGE LABEL. PRINCIPAL DISPLAY PANEL Desquam-X Wash (5%) 140 gram bottle (front) 140 gram bottle (back) Desquam-X Wash (10%) 140 gram bottle (front) 140 gram bottle (back) DESQUAM-X WASH benzoyl peroxide solution Product Information Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:10631-284 Route of Administration TOPICAL DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength BENZOYL PEROXIDE (BENZOYL PEROXIDE) BENZOYL PEROXIDE 5 mg in 1 mL Inactive Ingredients Ingredient Name Strength EDETIC ACID MAGNESIUM ACETATE Packaging # Item Code Package Description 1 NDC:10631-284-05 148 mL in 1 BOTTLE, PLASTIC Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date unapproved drug other 08/27/2008 DESQUAM-X WASH benzoyl peroxide solution Product Information Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:10631-285 Route of Administration TOPICAL DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength BENZOYL PEROXIDE (BENZOYL PEROXIDE) BENZOYL PEROXIDE 10 mg in 1 mL Inactive Ingredients Ingredient Name Strength EDETIC ACID MAGNESIUM ACETATE Packaging # Item Code Package Description 1 NDC:10631-285-05 148 mL in 1 BOTTLE, PLASTIC Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date unapproved drug other 05/02/2008 Labeler - Ranbaxy Laboratories Inc. (169932519) Registrant - Ranbaxy Laboratories Inc. (169932519) Establishment Name Address ID/FEI Operations Contract Pharmaceuticals Limited 248761249 manufacture Revised: 11/2009 Ranbaxy Laboratories Inc. Next Interactions Print this page Add to My Med List More about Desquam-X Wash (benzoyl peroxide topical) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group Pricing & Coupons En EspaƱol 1 Review Add your own review/rating Drug class: topical acne agents Consumer resources Desquam-X Wash Professional resources Benzoyl Peroxide Wash (FDA) Other brands: BenzePro , PanOxyl , Peroderm 7 Wash , Triaz , ... +15 more Related treatment guides Acne Perioral Dermatitis} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx OTC Availability Rx and/or OTC C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Topical acne agents Related Drugs topical acne agents clindamycin topical , erythromycin topical , tretinoin topical , tetracycline topical , dapsone topical , Finacea Acne doxycycline , clindamycin topical , erythromycin topical , minocycline , tretinoin topical , tetracycline topical , dapsone topical , Accutane , Vibramycin , Retin-A , isotretinoin , More... Perioral Dermatitis metronidazole topical , clindamycin topical , MetroGel , benzoyl peroxide topical , MetroCream , Cleocin T , Noritate , Clindagel , Acne Treatment , Oxy-10 , MetroLotion , Evoclin , More... Desquam-X Wash Rating 1 User Review 10 /10 1 User Review 10 Rate it!} } reduction


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