and you're going Esgic (Oral) Generic Name: butalbital and acetaminophen combination (Oral route) Commonly used brand name(s) In the U.S. Anolor 300 Cephadyn Dolgic LQ Esgic Esgic-Plus Ezol Fioricet Geone Margesic Orbivan CF Phrenilin Phrenilin Forte Available Dosage Forms: Tablet Capsule Solution Uses For Esgic Butalbital and acetaminophen combination is a pain reliever and relaxant. It is used to treat tension headaches. Butalbital belongs to the group of medicines called barbiturates. Barbiturates act in the central nervous system (CNS) to produce their effects. When you take butalbital for a long time, your body may get used to it so that larger amounts are needed to produce the same effects. This is called tolerance to the medicine. Also, butalbital may become habit-forming (causing mental or physical dependence) when it is used for a long time or in large doses. Physical dependence may lead to withdrawal side effects when you stop taking the medicine. In patients who get headaches, the first symptom of withdrawal may be new (rebound) headaches. Some butalbital and acetaminophen combinations also contain caffeine. Caffeine may help to relieve headaches. However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it. Butalbital and acetaminophen combination may also be used for other kinds of headaches or other kinds of pain as determined by your doctor. These medicines are available only with your doctor's prescription. Before Using Esgic Allergies Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric For butalbital : Although barbiturates such as butalbital often cause drowsiness, some children become excited after taking them. For acetaminophen : Acetaminophen has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults. For caffeine : There is no specific information comparing use of caffeine in children up to 12 years of age with use in other age groups. However, caffeine is not expected to cause different side effects or problems in children than it does in adults. Geriatric For butalbital : Certain side effects, such as confusion, excitement, or mental depression, may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of the butalbital in this combination medicine. For acetaminophen : Acetaminophen has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults. For caffeine : Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of caffeine in the elderly with use in other age groups. Pregnancy For butalbital : Barbiturates such as butalbital have been shown to increase the chance of birth defects in humans. Also, one study in humans has suggested that barbiturates taken during pregnancy may increase the chance of brain tumors in the baby. Butalbital may cause breathing problems in the newborn baby if taken just before or during delivery. For acetaminophen : Although studies on birth defects with acetaminophen have not been done in pregnant women, it has not been reported to cause birth defects or other problems. For caffeine : Studies in humans have not shown that caffeine (contained in some of these combination medicines) causes birth defects. However, use of large amounts of caffeine during pregnancy may cause problems with the heart rhythm and the growth of the fetus. Also, studies in animals have shown that caffeine causes birth defects when given in very large doses (amounts equal to those present in 12 to 24 cups of coffee a day). Breast Feeding For butalbital : Barbiturates such as butalbital pass into the breast milk and may cause drowsiness, unusually slow heartbeat, shortness of breath, or troubled breathing in nursing babies. For acetaminophen : Although acetaminophen has not been shown to cause problems in nursing babies, it passes into the breast milk in small amounts. For caffeine : Caffeine (present in some butalbital and acetaminophen combinations) passes into the breast milk in small amounts. Taking caffeine in the amounts present in these medicines has not been shown to cause problems in nursing babies. However, studies have shown that nursing babies may appear jittery and have trouble in sleeping when their mothers drink large amounts of caffeine-containing beverages. Therefore, breast-feeding mothers who use caffeine-containing medicines should probably limit the amount of caffeine they take in from other medicines or from beverages. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take. Riociguat Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alfentanil Alprazolam Amobarbital Anisindione Aprobarbital Butabarbital Butalbital Carisoprodol Chloral Hydrate Chlordiazepoxide Chlorzoxazone Clarithromycin Clobazam Clonazepam Clorazepate Dantrolene Darunavir Diazepam Dicumarol Doxorubicin Doxorubicin Hydrochloride Liposome Estazolam Ethchlorvynol Etonogestrel Flunitrazepam Flurazepam Halazepam Imatinib Isoniazid Ketazolam Lorazepam Lormetazepam Medazepam Mephenesin Mephobarbital Meprobamate Metaxalone Methocarbamol Methohexital Midazolam Nifedipine Nitrazepam Oxazepam Peginterferon Alfa-2b Pentobarbital Phenindione Phenobarbital Phenprocoumon Piperaquine Pixantrone Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate Prazepam Primidone Quazepam Regadenoson Secobarbital Sodium Oxybate Temazepam Thiopental Triazolam Ulipristal Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Using medicines in this class with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use your medicine, or give you special instructions about the use of food, alcohol, or tobacco. Ethanol Tobacco Other Medical Problems The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse (or history of) or Drug abuse or dependence (or history of) Dependence on butalbital may develop. Also, acetaminophen may cause liver damage in people who abuse alcohol. Asthma (or history of), emphysema, or other chronic lung disease or Hepatitis or other liver disease or Hyperactivity (in children) or Kidney disease The chance of serious side effects may be increased. Type 2 diabetes mellitus or Mental depression or Overactive thyroid or Porphyria (or history of) Butalbital can make these conditions worse. Heart disease (severe) The caffeine in some butalbital and acetaminophen combinations can make some kinds of heart disease worse. Proper Use of butalbital and acetaminophen combination This section provides information on the proper use of a number of products that contain butalbital and acetaminophen combination. It may not be specific to Esgic. Please read with care. Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If butalbital and acetaminophen combination is taken regularly (for example, every day), it may become habit-forming (causing mental or physical dependence). The caffeine in some butalbital and acetaminophen combinations can also increase the chance of dependence. Dependence is especially likely to occur in patients who take these medicines to relieve frequent headaches. Taking too much of this medicine may also lead to liver damage or other medical problems. This medicine will relieve a headache best if you take it as soon as the headache begins . If you get warning signs of a migraine, take this medicine as soon as you are sure that the migraine is coming. This may even stop the headache pain from occurring. Lying down in a quiet, dark room for a while after taking the medicine also helps to relieve headaches . People who get a lot of headaches may need to take a different medicine to help prevent headaches. It is important that you follow your doctor's directions about taking the other medicine, even if your headaches continue to occur . Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headaches should occur less often, and they should be less severe and easier to relieve than before. This will reduce the amount of headache relievers that you need. If you do not notice any improvement after several weeks of headache-preventing treatment, check with your doctor. Dosing The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage forms (capsules or tablets): For tension headaches: Adults One or 2 capsules or tablets every four hours as needed. If your medicine contains 325 or 500 milligrams (mg) of acetaminophen in each capsule or tablet, you should not take more than six capsules or tablets a day. If your medicine contains 650 mg of acetaminophen in each capsule or tablet, you should not take more than four capsules or tablets a day. Children Dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Do not keep outdated medicine or medicine no longer needed. Precautions While Using Esgic Check with your doctor : If the medicine stops working as well as it did when you first started using it. This may mean that you are in danger of becoming dependent on the medicine. Do not try to get better pain relief by increasing the dose. If you are having headaches more often than you did before you started taking this medicine. This is especially important if a new headache occurs within 1 day after you took your last dose of this medicine, headaches begin to occur every day, or a headache continues for several days in a row. This may mean that you are dependent on the medicine. Continuing to take this medicine will cause even more headaches later on. Your doctor can give you advice on how to relieve the headaches. Check the labels of all nonprescription (over-the-counter [OTC]) or prescription medicines you now take. If any contain a barbiturate or acetaminophen, check with your health care professional . Taking them together with this medicine may cause an overdose. The butalbital in this medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine; narcotics; other barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Also, drinking large amounts of alcoholic beverages regularly while taking this medicine may increase the chance of liver damage, especially if you take more of this medicine than your doctor ordered or if you take it regularly for a long time. Therefore, do not drink alcoholic beverages, and check with your doctor before taking any of the medicines listed above, while you are using this medicine . This medicine may cause some people to become drowsy, dizzy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded . Before you have any medical tests, tell the person in charge that you are taking this medicine. Caffeine (present in some butalbital and acetaminophen combinations) interferes with the results of certain tests that use dipyridamole (e.g., Persantine) to help show how well blood is flowing to your heart. Caffeine should not be taken for 8 to 12 hours before the test. The results of other tests may also be affected by butalbital and acetaminophen combinations. Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine. Serious side effects can occur if your medical doctor or dentist gives you certain medicines without knowing that you have taken butalbital. If you have been taking large amounts of this medicine, or if you have been taking it regularly for several weeks or more, do not suddenly stop taking it without first checking with your doctor . Your doctor may want you to reduce gradually the amount you are taking before stopping completely in order to lessen the chance of withdrawal side effects. If you think you or anyone else may have taken an overdose of this medicine, get emergency help at once . Taking an overdose of this medicine or taking alcohol or CNS depressants with this medicine may lead to unconsciousness or possibly death. Signs of butalbital overdose include severe drowsiness, confusion, severe weakness, shortness of breath or unusually slow or troubled breathing, slurred speech, staggering, and unusually slow heartbeat. Signs of severe acetaminophen poisoning may not occur until 2 to 4 days after the overdose is taken, but treatment to prevent liver damage or death must be started within 24 hours or less after the overdose is taken. Esgic Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare Bleeding or crusting sores on lips chest pain fever with or without chills hive-like swellings (large) on eyelids, face, lips, and/or tongue muscle cramps or pain red, thickened, or scaly skin shortness of breath, troubled breathing, tightness in chest, or wheezing skin rash, itching, or hives sores, ulcers, or white spots in mouth (painful) Symptoms of overdose Anxiety, confusion, excitement, irritability, nervousness, restlessness, or trouble in sleeping (severe, especially with products containing caffeine) convulsions (seizures) (for products containing caffeine) diarrhea, especially if occurring together with increased sweating, loss of appetite, and stomach cramps or pain dizziness, lightheadedness, drowsiness, or weakness, (severe) frequent urination (for products containing caffeine) hallucinations (seeing, hearing, or feeling things that are not there) increased sensitivity to touch or pain (for products containing caffeine) muscle trembling or twitching (for products containing caffeine) nausea or vomiting, sometimes with blood ringing or other sounds in ears (for products containing caffeine) seeing flashes of "zig-zag" lights (for products containing caffeine) shortness of breath or unusually slow or troubled breathing slow, fast, or irregular heartbeat slurred speech staggering swelling, pain, or tenderness in the upper abdomen or stomach area unusual movements of the eyes Check with your doctor as soon as possible if any of the following side effects occur: Less common Confusion (mild) mental depression unusual excitement (mild) Rare Bloody or black, tarry stools bloody urine pinpoint red spots on skin swollen or painful glands unusual bleeding or bruising unusual tiredness or weakness (mild Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Bloated or "gassy" feeling dizziness or lightheadedness (mild) drowsiness (mild) nausea, vomiting, or stomach pain (occurring without other symptoms of overdose) Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Print this page The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. 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