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the correct alogliptin and pioglitazone (Oral route) al-oh-GLIP-tin BEN-zoe-ate, pye-oh-GLI-ta-zone hye-droe-KLOR-ide Oral route(Tablet) May cause or worsen congestive heart failure, is not recommended in patients with symptomatic heart failure, and is contraindicated in patients with established NYHA Class III or IV heart failure. Monitor patients for signs and symptoms of heart failure after initiation or dose increases. If heart failure occurs, consider dose reduction of pioglitazone in the alogliptin/pioglitazone combination or discontinue pioglitazone and manage according to current standards of care . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Oseni Available Dosage Forms: Tablet Therapeutic Class: Antidiabetic Pharmacologic Class: Alogliptin Chemical Class: Pioglitazone Slideshow Understanding Insulin: What You Need To Know Uses For alogliptin and pioglitazone Alogliptin and pioglitazone combination is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. Alogliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. Pioglitazone works by helping your body use insulin better. alogliptin and pioglitazone does not help patients who have insulin-dependent or type 1 diabetes. alogliptin and pioglitazone is available only with your doctor's prescription. Before Using alogliptin and pioglitazone In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For alogliptin and pioglitazone, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to alogliptin and pioglitazone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of alogliptin and pioglitazone combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alogliptin and pioglitazone combination in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking alogliptin and pioglitazone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using alogliptin and pioglitazone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acarbose Balofloxacin Besifloxacin Chlorpropamide Ciprofloxacin Enoxacin Fleroxacin Flumequine Gatifloxacin Gemifloxacin Glimepiride Glipizide Glyburide Ifosfamide Insulin Insulin Aspart, Recombinant Insulin Bovine Insulin Degludec Insulin Detemir Insulin Glargine, Recombinant Insulin Glulisine Insulin Lispro, Recombinant Lanreotide Levofloxacin Lomefloxacin Metformin Moxifloxacin Nadifloxacin Nateglinide Nifedipine Norfloxacin Octreotide Ofloxacin Pasireotide Pazufloxacin Pefloxacin Piperaquine Pixantrone Prulifloxacin Repaglinide Rufloxacin Sparfloxacin Thioctic Acid Tolazamide Tolbutamide Tolvaptan Tosufloxacin Using alogliptin and pioglitazone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Atenolol Atorvastatin Betaxolol Bisoprolol Bitter Melon Carteolol Carvedilol Celiprolol Esmolol Fenugreek Glucomannan Guar Gum Ketoconazole Labetalol Levobunolol Metipranolol Metoprolol Nadolol Nebivolol Nilotinib Oxprenolol Penbutolol Pindolol Practolol Propranolol Psyllium Rifampin Sotalol Timolol Topiramate Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of alogliptin and pioglitazone. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol, excessive use of or Angioedema (severe allergic reaction), history of with similar antidiabetic medicine or Fragile bones or Gallbladder stones or Pancreas problems, history of Use with caution. May cause side effects to become worse. Congestive heart failure or Diabetic macular edema (eye disorder) or Edema (fluid retention) or Liver disease Use with caution. May make these conditions worse. Kidney disease, moderate Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of alogliptin and pioglitazone Carefully follow the special meal plan your doctor gave you . This is the most important part of controlling your diabetes, and is necessary if the medicine is to work properly. Exercise regularly and test for sugar in your blood or urine as directed. alogliptin and pioglitazone should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. You may take alogliptin and pioglitazone with or without food. Swallow the tablet whole. Do not split, crush, break, or chew it. Dosing The dose of alogliptin and pioglitazone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of alogliptin and pioglitazone. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For type 2 diabetes: Adults At first, one tablet once a day. The tablet may contain either alogliptin 25 milligrams [mg] plus pioglitazone 15 mg or alogliptin 25 mg plus pioglitazone 30 mg. Your doctor may adjust your dose as needed. However, the dose is usually not more than alogliptin 25 mg plus pioglitazone 45 mg per day. Children Use is not recommended. Missed Dose If you miss a dose of alogliptin and pioglitazone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using alogliptin and pioglitazone It is very important that your doctor check your progress at regular visits to make sure that alogliptin and pioglitazone is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects. Certain women may be at an increased risk for pregnancy while taking alogliptin and pioglitazone. If you had problems ovulating and had irregular periods in the past, alogliptin and pioglitazone may cause you to ovulate. This could increase your chance of becoming pregnant. If you are a woman of childbearing potential, you should discuss birth control options with your doctor. If you are rapidly gaining weight, having trouble breathing, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or fluid retention (too much water in the body). Pancreatitis (swelling and inflammation of the pancreas) may occur while you are using alogliptin and pioglitazone. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, loss of appetite, fever, or lightheadedness. alogliptin and pioglitazone may cause serious allergic reactions, including anaphylaxis, angioedema, or certain skin conditions (Stevens-Johnson syndrome). These reactions can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, blistering, peeling, or loosening of the skin, fever or chills, trouble breathing or swallowing, or any swelling of your hands, face, mouth, or throat while you are using alogliptin and pioglitazone. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. alogliptin and pioglitazone may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures. Using alogliptin and pioglitazone for a long time may increase your risk for bladder cancer. Tell your doctor right away if you have blood in the urine, a frequent, strong, or increased urge to urinate, painful urination, or pain in the back, lower abdomen, or stomach. Check with your doctor right away if blurred vision, decreased vision, or any other change in vision occurs while you are taking alogliptin and pioglitazone. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). alogliptin and pioglitazone may cause hypoglycemia (low blood sugar). Low blood sugar can also occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, cannot eat because of nausea or vomiting, take certain medicines, or take alogliptin with another type of diabetes medicine (eg, insulin, glimepiride, glipizide, glyburide, or metformin). Low blood sugar must be treated before it causes you to pass out (unconsciousness). People feel different symptoms with low blood sugar . It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat low blood sugar. Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your diet plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away . It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar. There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says you have diabetes with a list of all your medicines. alogliptin and pioglitazone may cause severe and disabling joint pain. Call your doctor right away if you have severe joint pain while using alogliptin and pioglitazone. alogliptin and pioglitazone may cause bullous pemphigoid. Tell your doctor if you have large, hard skin blisters while using alogliptin and pioglitazone. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. alogliptin and pioglitazone Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Anxiety blurred vision chest pain chills cold sweats confusion cool, pale skin decreased urine output depression dilated neck veins dizziness extreme fatigue fast heartbeat headache increased hunger irregular breathing irregular heartbeat nausea nightmares seizures shakiness slurred speech swelling of the face, fingers, feet, or lower legs tightness in the chest troubled breathing unusual tiredness or weakness weight gain Rare Blistering, peeling, or loosening of the skin bloating blood in the urine constipation cough darkened urine diarrhea difficulty with swallowing feeling of discomfort fever frequent, strong, or increased urge to urinate hives, itching, or rash indigestion inflammation of the joints joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs loss of appetite muscle aches pain in the back, lower abdomen, or stomach painful urination pains in the stomach, side, or abdomen, possibly radiating to the back puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue red skin lesions, often with a purple center red, irritated eyes sore throat sores, ulcers, or white spots in the mouth or on the lips swollen lymph glands vomiting yellow eyes or skin Incidence not known Change in vision general feeling of tiredness or weakness light-colored stools severe joint pain stomach pain, continuing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Back pain body aches or pain ear congestion loss of voice sneezing stuffy or runny nose Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about alogliptin/pioglitazone Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: antidiabetic combinations Consumer resources Alogliptin and pioglitazone Other brands: Oseni Professional resources Alogliptin and Pioglitazone Tablets (FDA) Alogliptin and Pioglitazone (Wolters Kluwer) Related treatment guides Diabetes, Type 2} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Perrigo Company Drug Class Antidiabetic combinations Related Drugs Diabetes, Type 2 metformin , insulin aspart , glipizide , glimepiride , Januvia , pioglitazone , Victoza , Actos , Tradjenta , Glucophage , glyburide , Janumet , Invokana , Amaryl , Welchol , Onglyza , sitagliptin , Trulicity , Jardiance , Lantus , Farxiga , Levemir , Tresiba , Glucotrol , Bydureon , More... Alogliptin / pioglitazone Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Alogliptin / pioglitazone Images Alogliptin / pioglitazone systemic 25 mg / 30 mg (A/P 25/30 ) View larger images Help and Support Looking for answers? Ask a question or go join the alogliptin / pioglitazone support group to connect with others who have similar interests.} } of moral


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