outcome alogliptin (Oral route) al-oh-GLIP-tin BEN-zoe-ate Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Nesina Available Dosage Forms: Tablet Therapeutic Class: Antidiabetic Pharmacologic Class: Alogliptin Slideshow Prediabetes - Am I At Risk? Uses For alogliptin Alogliptin is used together with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. Alogliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. alogliptin does not help patients who have insulin-dependent or type 1 diabetes. alogliptin is available only with your doctor's prescription. Before Using alogliptin In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For alogliptin, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to alogliptin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of alogliptin in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alogliptin in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking alogliptin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using alogliptin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Balofloxacin Besifloxacin Ciprofloxacin Enoxacin Fleroxacin Flumequine Gatifloxacin Gemifloxacin Lanreotide Levofloxacin Lomefloxacin Moxifloxacin Nadifloxacin Norfloxacin Octreotide Ofloxacin Pasireotide Pazufloxacin Pefloxacin Prulifloxacin Rufloxacin Sparfloxacin Thioctic Acid Tosufloxacin Using alogliptin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Atenolol Betaxolol Bisoprolol Carteolol Carvedilol Celiprolol Esmolol Labetalol Levobunolol Metipranolol Metoprolol Nadolol Nebivolol Oxprenolol Penbutolol Pindolol Practolol Propranolol Sotalol Timolol Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of alogliptin. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol, excessive use of or Gallbladder stones or Pancreas problems, history of Use with caution. May increase risk for getting pancreatitis (swelling and inflammation of the pancreas). Angioedema (swelling of the face, lips, tongue, throat, arms, or legs), history with this dipeptidyl peptidase-4 (DPP-4) inhibitors Use with caution. May increase the risk of this condition occurring again with alogliptin. Diabetic ketoacidosis (high ketones and acid in the blood) or Type 1 diabetes Should not be used in patients with these conditions. Heart failure, history of or Kidney disease, history of Use with caution. May increase the risk of serious side effects. Kidney disease, moderate or severe Use with caution. The effects may be increased because of slower removal of the medicine from the body. Liver disease Use with caution. May make this condition worse. Proper Use of alogliptin Your doctor will tell you how much of alogliptin to use and how often . Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to. alogliptin should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Carefully follow the special meal plan your doctor gave you . This is the most important part of controlling your diabetes, and is necessary if the medicine is to work properly. Exercise regularly and test for sugar in your blood or urine as directed. You may take alogliptin with or without food. Dosing The dose of alogliptin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of alogliptin. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For type 2 diabetes: Adults 25 milligrams (mg) once a day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of alogliptin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using alogliptin It is very important that your doctor check your progress at regular visits to make sure that alogliptin is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects. alogliptin may cause serious allergic reactions, including anaphylaxis, angioedema, or certain skin conditions (eg, Stevens-Johnson syndrome). These reactions can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, blistering, peeling, or loose skin, fever or chills, trouble breathing or swallowing, or any swelling of your hands, face, mouth, or throat while you are using alogliptin. Pancreatitis (swelling and inflammation of the pancreas) may occur while you are using alogliptin. Check with your doctor right away if you have a sudden and severe stomach pain, chills, constipation, nausea, vomiting, loss of appetite, fever, or lightheadedness. If you are rapidly gaining weight, having shortness of breath, chest pain, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of a heart problem. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. alogliptin may cause hypoglycemia (low blood sugar). This is more common when alogliptin is taken together with certain medicines. Low blood sugar must be treated before it causes you to pass out (unconsciousness). People feel different symptoms of low blood sugar . It is important that you learn which symptoms you usually have so you can treat it quickly. Talk to your doctor about the best way to treat low blood sugar. Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away . It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar. There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says you have diabetes with a list of all your medicines. alogliptin may cause severe and disabling joint pain. Call your doctor right away if you have severe joint pain while using alogliptin. alogliptin may cause bullous pemphigoid. Tell your doctor right away if you have large, hard skin blisters while you are using alogliptin. alogliptin Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Anxiety blurred vision chills cold sweats coma confusion cool, pale skin depression dizziness fast heartbeat headache increased hunger nausea nightmares seizures shakiness slurred speech unusual tiredness or weakness Less common Chest pain decreased urine output dilated neck veins extreme fatigue irregular breathing irregular heartbeat swelling of the face, fingers, feet, or lower legs tightness in chest troubled breathing weight gain Rare Blistering, peeling, or loosening of the skin bloating constipation cough dark-colored urine diarrhea difficulty with swallowing feeling of discomfort fever general feeling of tiredness or weakness headache hives, itching, or rash indigestion inflammation of the joints joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools loss of appetite muscle aches pains in the stomach, side, or abdomen, possibly radiating to the back puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue red skin lesions, often with a purple center red, irritated eyes sore throat sores, ulcers, or white spots in the mouth or on the lips stomach pain, continuing swollen lymph glands tightness in the chest vomiting yellow eyes or skin Incidence not known Redness of the skin severe joint pain Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Body aches or pain ear congestion loss of voice sneezing stuffy or runny nose Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. 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Next Side Effects Print this page Add to My Med List More about alogliptin Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 4 Reviews Add your own review/rating Drug class: dipeptidyl peptidase 4 inhibitors Consumer resources Alogliptin Other brands: Nesina Professional resources Alogliptin Benzoate (AHFS Monograph) Alogliptin (FDA) Alogliptin (Wolters Kluwer) Related treatment guides Diabetes, Type 2} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Perrigo Company Drug Class Dipeptidyl peptidase 4 inhibitors Related Drugs Diabetes, Type 2 metformin , insulin aspart , glipizide , glimepiride , Januvia , pioglitazone , Victoza , Actos , Tradjenta , Glucophage , glyburide , Janumet , Invokana , Amaryl , Welchol , Onglyza , sitagliptin , Trulicity , Jardiance , Lantus , Farxiga , Levemir , Tresiba , Glucotrol , Bydureon , More... 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