well-deserved rifapentine Generic Name: rifapentine (RIF a PEN teen) Brand Name: Priftin Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A What is rifapentine? Rifapentine is an antibiotic that fights bacteria. Rifapentine is used together with other medicines to treat active tuberculosis (TB) in adults and children who are at least 12 years old. Rifapentine is also used to keep inactive (latent) TB from becoming active in adults and children who are at least 2 years old. Rifapentine must always be used in combination with other tuberculosis medications. Rifapentine may also be used for purposes not listed in this medication guide. Slideshow Drug Treatments for Rheumatoid Arthritis - What Are Your Options? What is the most important information I should know about rifapentine? Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. What should I discuss with my healthcare provider before taking rifapentine? You should not take this medicine if you are allergic to rifapentine, rifabutin (Mycobutin), or rifampin (Rifadin, Rifater, Rimactane, Rifamate). To make sure rifapentine is safe for you, tell your doctor if you have: liver disease; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); HIV or AIDS; if you have used rifampin or isoniazid in the past and they were not effective in treating TB; or if you have been exposed to someone with TB that could not be treated with rifampin or isoniazid. FDA pregnancy category C. It is not known whether rifapentine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Rifapentine can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking rifapentine. It is not known whether rifapentine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Rifapentine may cause a red-orange discoloration of breast milk. Do not give this medicine to a child without medical advice. How should I take rifapentine? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take with food. To make swallowing easier, you may crush the rifapentine tablet and sprinkle the medicine into a spoonful of pudding, applesauce, or other soft food. Swallow this mixture right away. Do not save the mixture for later use. Use this medicine for the full prescribed length of time. Your TB may get better and then come back if you do not take rifapentine as directed. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Rifapentine will not treat a viral infection such as the flu or a common cold. Call your doctor if your symptoms do not improve, or if they get worse while using rifapentine. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking rifapentine? Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using rifapentine and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to. Rifapentine side effects Get emergency medical help if you have any of these signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: diarrhea that is watery or bloody; liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing. Rifapentine can cause changes in the color of your skin or body fluids. You may notice a red-orange appearance of your skin, tears, sweat, saliva, urine, or stools. Your teeth, tongue, or the inside of your mouth may also appear red-orange. This discoloration can permanently stain contact lenses or dentures. Common side effects may include: nausea, vomiting, diarrhea, loss of appetite; flu symptoms; headache, joint pain; itching or rash; eye redness; or abnormal liver function tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Rifapentine dosing information Usual Adult Dose for Tuberculosis -- Active: Initial intensive phase dose: 600 mg orally two times a week with at least 72 hours between doses for 2 months Rifapentine should be administered by direct observation of therapy in combination with daily companion drugs (such as ethambutol, pyrazinamide, and streptomycin) during the initial treatment phase. The determination of the companion drugs should be made by the treating physician and depends on susceptibility testing results as well as treatment phase. Continuation phase dose: Following the 2 month intensive phase, 600 mg orally once a week for at least 4 months The continuation treatment phase may consist of rifapentine with isoniazid or an appropriate antituberculosis agent for susceptible organisms by direct observation therapy. The treating physician should consult current guidelines for additional direction on other possible components of the continuation phase as well as for directions on extending this phase. Usual Pediatric Dose for Tuberculosis -- Active: 15 years or older: Initial intensive phase dose: 600 mg orally two times a week with at least 72 hours between doses for 2 months Rifapentine should be administered by direct observation of therapy in combination with daily companion drugs (such as ethambutol, pyrazinamide, and streptomycin) during the initial treatment phase. The determination of the companion drugs should be made by the treating physician and depends on susceptibility testing results as well as treatment phase. Continuation phase dose: Following the 2 month intensive phase, 600 mg orally once a week for at least 4 months The continuation treatment phase may consist of rifapentine with isoniazid or an appropriate antituberculosis agent for susceptible organisms by direct observation therapy. The treating physician should consult current guidelines for additional direction on other possible components of the continuation phase as well as for directions on extending this phase. Pharmacokinetics study (n=2) 12 years to less than 15 years weighing less than 45 kg: Initial intensive phase dose: 450 mg orally two times a week with at least 72 hours between doses for 2 months Continuation phase dose: 450 mg orally once a week for at least 4 months following the initial phase Pharmacokinetics study (n=10) 12 years to less than 15 years weighing 45 kg or more: Initial intensive phase dose: 600 mg orally two times a week with at least 72 hours between doses for 2 months Continuation phase dose: 600 mg orally once a week for at least 4 months following the initial phase What other drugs will affect rifapentine? Many drugs can interact with rifapentine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about rifapentine Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: rifamycin derivatives Consumer resources Rifapentine Rifapentine (Advanced Reading) Other brands: Priftin Professional resources Rifapentine (AHFS Monograph) Rifapentine (Wolters Kluwer) Related treatment guides Tuberculosis, Active Tuberculosis, Latent Where can I get more information? Your pharmacist can provide more information about rifapentine. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01. Date modified: December 03, 2017 Last reviewed: December 10, 2014} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Rifamycin derivatives Related Drugs Tuberculosis, Latent rifampin , isoniazid , pyrazinamide , Rifadin , Nydrazid , Rimactane , Priftin , More... Tuberculosis, Active ciprofloxacin , Levaquin , levofloxacin , rifampin , moxifloxacin , Avelox , isoniazid , ethambutol , amikacin , gatifloxacin , More... Rifapentine Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the rifapentine support group to connect with others who have similar interests.} } inspired
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