muscle mass rifampin and isoniazid (Oral route) rif-AM-pin, eye-soe-NYE-a-zid Oral route(Capsule) Severe and sometimes fatal hepatitis has been reported with isoniazid therapy and may occur even after many months of treatment. The risk for hepatitis generally increases with advancing age and alcohol use. Monthly clinical evaluation and liver function tests should be performed. Instruct patients to report immediately any of the prodromal symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid should be discontinued promptly. If isoniazid must be reinstituted, it should be reinstituted only after symptoms and laboratory abnormalities have cleared. The drug should be restarted in very small and gradually increasing doses and should be withdrawn immediately if there is any indication of recurrent liver involvement. Treatment should be deferred in persons with acute hepatic diseases . Overview Side Effects Dosage Interactions Pregnancy More User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. IsonaRif Rifamate Available Dosage Forms: Capsule Tablet Therapeutic Class: Antitubercular Combination Chemical Class: Rifamycin Slideshow Hives: The What, Where, And Why Of This Bizarre Skin Condition Uses For rifampin and isoniazid Rifampin and isoniazid is a combination antibiotic and anti-infective medicine. This combination medication is used to treat tuberculosis (TB). It may be taken alone or with one or more other medicines for TB. To help clear up your tuberculosis (TB) infection completely, you must keep taking rifampin and isoniazid for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses. Rifampin and isoniazid combination is available only with your doctor's prescription. Before Using rifampin and isoniazid In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rifampin and isoniazid, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to rifampin and isoniazid or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Rifampin and isoniazid combination is not recommended for use in children. Geriatric Liver problems are more likely to occur in patients over 50 years of age who are taking isoniazid-containing medicines. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rifampin and isoniazid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using rifampin and isoniazid with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Artemether Atazanavir Boceprevir Cobicistat Daclatasvir Darunavir Dasabuvir Delamanid Elbasvir Elvitegravir Fosamprenavir Grazoprevir Isavuconazonium Lopinavir Lurasidone Maraviroc Nelfinavir Ombitasvir Paritaprevir Praziquantel Ranolazine Rilpivirine Ritonavir Saquinavir Telaprevir Tipranavir Voriconazole Using rifampin and isoniazid with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Acetaminophen Afatinib Amiodarone Amprenavir Apixaban Apremilast Aprepitant Aripiprazole Atovaquone Axitinib Bedaquiline Bosutinib Brexpiprazole Brigatinib Brivaracetam Bupropion Cabozantinib Carbamazepine Cariprazine Ceritinib Cholera Vaccine, Live Clozapine Cobimetinib Crizotinib Cyclosporine Dabigatran Etexilate Dasatinib Deferasirox Deflazacort Delavirdine Desogestrel Dienogest Digoxin Dolutegravir Domperidone Donepezil Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Drospirenone Edoxaban Efavirenz Eliglustat Eluxadoline Enzalutamide Erlotinib Estradiol Ethinyl Estradiol Ethionamide Ethynodiol Etonogestrel Etravirine Everolimus Exemestane Fentanyl Fosaprepitant Fosphenytoin Gefitinib Gestodene Glimepiride Ibrutinib Idelalisib Ifosfamide Imatinib Indinavir Irinotecan Irinotecan Liposome Isoniazid Itraconazole Ivabradine Ivacaftor Ixabepilone Ixazomib Ketoconazole Lamotrigine Lapatinib Ledipasvir Levodopa Levonorgestrel Linagliptin Lorcainide Macitentan Manidipine Mestranol Methadone Midostaurin Mifepristone Mycophenolate Mofetil Mycophenolic Acid Naloxegol Netupitant Nevirapine Nifedipine Nilotinib Nimodipine Nintedanib Norethindrone Norgestimate Norgestrel Olaparib Osimertinib Palbociclib Panobinostat Pazopanib Perampanel Phenytoin Piperaquine Pitavastatin Pixantrone Ponatinib Posaconazole Pyrazinamide Quetiapine Quinine Regorafenib Ribociclib Rifampin Rivaroxaban Roflumilast Rolapitant Romidepsin Simeprevir Sirolimus Sofosbuvir Sonidegib Sorafenib Sunitinib Tacrolimus Tasimelteon Tegafur Telithromycin Temsirolimus Tenofovir Alafenamide Thiotepa Ticagrelor Tofacitinib Tolvaptan Trabectedin Ulipristal Valbenazine Vandetanib Velpatasvir Vemurafenib Venetoclax Vilazodone Vincristine Vincristine Sulfate Liposome Vinflunine Vorapaxar Vortioxetine Using rifampin and isoniazid with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acetyldigoxin Aliskiren Aminosalicylic Acid Anisindione Aripiprazole Lauroxil Atorvastatin Betamethasone Bexarotene Bosentan Buspirone Carbamazepine Carvedilol Caspofungin Chloramphenicol Chlorpropamide Citalopram Clarithromycin Clofibrate Cortisone Dexamethasone Diazepam Dicumarol Diltiazem Disopyramide Disulfiram Doxycycline Eltrombopag Enalaprilat Enalapril Maleate Enflurane Etoricoxib Fesoterodine Fluconazole Fludrocortisone Fosphenytoin Gliclazide Glyburide Haloperidol Isradipine Levomethadyl Levothyroxine Linezolid Losartan Mefloquine Meperidine Metformin Methylprednisolone Metoprolol Morphine Morphine Sulfate Liposome Moxifloxacin Nisoldipine Ospemifene Oxcarbazepine Oxycodone Phenprocoumon Phenytoin Pioglitazone Pirmenol Prednisolone Prednisone Propafenone Raltegravir Repaglinide Rofecoxib Rosiglitazone Sertraline Simvastatin Tadalafil Tamoxifen Theophylline Tocainide Triazolam Trimetrexate Valproic Acid Warfarin Zaleplon Zidovudine Zolpidem Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using rifampin and isoniazid with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use rifampin and isoniazid, or give you special instructions about the use of food, alcohol, or tobacco. Ethanol Using rifampin and isoniazid with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use rifampin and isoniazid, or give you special instructions about the use of food, alcohol, or tobacco. food Tyramine Containing Food Other Medical Problems The presence of other medical problems may affect the use of rifampin and isoniazid. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse (or history of) or Liver disease There may be an increased chance of getting hepatitis if you take rifampin and isoniazid and drink alcohol daily Convulsive disorders such as seizures or epilepsy Rifampin and isoniazid combination may increase the frequency of seizures (convulsions) in some patients Kidney disease (severe) There may be an increased chance of side effects in patients with severe kidney disease Proper Use of rifampin and isoniazid If rifampin and isoniazid upsets your stomach, take it with food. Antacids may also help. However, do not take aluminum-containing antacids within 1 hour of the time you take rifampin and isoniazid combination. They may keep rifampin and isoniazid from working properly. To help clear up your tuberculosis (TB) completely, it is very important that you keep taking rifampin and isoniazid for the full time of treatment, even if you begin to feel better after a few weeks. You may have to take it every day for as long as 1 to 2 years or more. It is important that you do not miss any doses. Your doctor may also want you to take pyridoxine (e.g., Hexa-Betalin, vitamin B 6) every day to help prevent or lessen some of the side effects of isoniazid. If it is needed, it is very important to take pyridoxine every day along with rifampin and isoniazid. Do not miss any doses. Dosing The dose of rifampin and isoniazid will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rifampin and isoniazid. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For the oral dosage form (capsules): For the treatment of tuberculosis: Adults and older children 600 milligrams (mg) of rifampin and 300 mg of isoniazid once a day. Children This combination medicine is not recommended for use in children. Missed Dose If you miss a dose of rifampin and isoniazid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using rifampin and isoniazid It is very important that your doctor check your progress at regular visits. In addition, you should check with your doctor immediately if blurred vision or loss of vision, with or without eye pain, occurs during treatment. He or she may want you to have your eyes checked by an ophthalmologist (eye doctor). If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor. Oral contraceptives (birth control pills) containing estrogen may not work properly if you take them while you are taking rifampin and isoniazid combination. Unplanned pregnancies may occur. You should use a different means of birth control while you are taking rifampin and isoniazid. If you have any questions about this, check with your health care professional. Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking rifampin and isoniazid. Also, the regular use of alcohol may keep rifampin and isoniazid from working properly. Therefore, you should strictly limit the amount of alcoholic beverages you drink while you are taking rifampin and isoniazid. Certain foods such as cheese (Swiss or Cheshire) or fish (tuna, skipjack, or Sardinella) may rarely cause reactions in some patients taking isoniazid-containing medicines. Check with your doctor if redness or itching of the skin, hot feeling, fast or pounding heartbeat, sweating, chills or clammy feeling, headache, or lightheadedness occurs after eating these foods while you are taking rifampin and isoniazid. rifampin and isoniazid will cause the urine, stool, saliva, sputum, sweat, and tears to turn reddish-orange to reddish-brown. This is to be expected while you are taking rifampin and isoniazid. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. Therefore, it is best not to wear soft contact lenses while taking rifampin and isoniazid. This condition will return to normal once you stop taking rifampin and isoniazid. Hard contact lenses are not discolored by rifampin and isoniazid. If you have any questions about this, check with your doctor. If rifampin and isoniazid causes you to feel very tired or very weak; or causes clumsiness; unsteadiness; a loss of appetite; nausea; numbness, tingling, burning, or pain in the hands and feet; or vomiting, stop taking it and check with your doctor immediately. These may be early warning symptoms of more serious liver or nerve problems that could develop later. Rifampin and isoniazid combination may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. rifampin and isoniazid Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Clumsiness or unsteadiness dark urine loss of appetite nausea and vomiting numbness, tingling, burning, or pain in hands and feet unusual tiredness or weakness yellow eyes or skin Less common Chills difficult breathing dizziness fever headache itching muscle and bone pain shivering skin rash and redness Rare Bloody or cloudy urine blurred vision or loss of vision, with or without eye pain convulsions (seizures) depression greatly decreased frequency of urination or amount of urine mood or mental changes sore throat unusual bleeding or bruising Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea stomach pain or upset Less common Sore mouth or tongue rifampin and isoniazid commonly causes reddish-orange to reddish-brown discoloration of urine, stool, saliva, sputum, sweat, and tears. This side effect does not usually require medical attention. Dark urine and yellowing of the eyes or skin (signs of liver problems) are more likely to occur in patients 50 years of age and older. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. 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Next Side Effects Print this page Add to My Med List More about isoniazid/rifampin Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: antituberculosis combinations Consumer resources Isoniazid and rifampin Rifampin and Isoniazid Other brands: Rifamate , IsonaRif Professional resources Related treatment guides Tuberculosis, Active} Drug Status Rx Availability Prescription only N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antituberculosis combinations Related Drugs Tuberculosis, Active ciprofloxacin , Levaquin , levofloxacin , rifampin , moxifloxacin , Avelox , isoniazid , ethambutol , amikacin , gatifloxacin , streptomycin , pyrazinamide , Floxin , Rifadin , Amikin , Myambutol , cycloserine , Tequin , isoniazid / pyrazinamide / rifampin , rifapentine , ethionamide , kanamycin , Rifamate , More... Isoniazid / rifampin Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Related Questions & Answers Isoniazid/Rifampin what are the long term side effects? Read more questions} } really fizzling out
mood rifampin and isoniazid (Oral route) quite a few
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