today Duo-Vil 2-25 (Oral) Generic Name: perphenazine and amitriptyline (Oral route) per-FEN-a-zeen, am-i-TRIP-ti-leen hye-droe-KLOR-ide Oral route(Tablet) Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Perphenazine and amitriptyline hydrochloride is not approved for the treatment of patients with dementia-related psychosis.Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. Short term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. This risk must be balanced with the clinical need. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Perphenazine and amitriptyline hydrochloride is not approved for use in pediatric patients . Overview Side Effects Interactions Pregnancy Reviews More Support Group Q & A Commonly used brand name(s) In the U.S. Duo-Vil 2-10 Duo-Vil 2-25 Etrafon Available Dosage Forms: Tablet Therapeutic Class: Tricyclic Antidepressant/Phenothiazine Combination Pharmacologic Class: Phenothiazine Chemical Class: Piperazine (class) Slideshow Breaking Down Bipolar Disorder - 12 Things You Need To Know Uses For Duo-Vil 2-25 Perphenazine and amitriptyline combination is used to treat certain mental and emotional conditions. This combination is available only with your doctor's prescription. Before Using Duo-Vil 2-25 In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Certain side effects, such as muscle spasms of the face, neck, and back, tic-like or twitching movements, inability to move the eyes, twisting of the body, or weakness of the arms and legs, are more likely to occur in children, who are usually more sensitive than adults to some of the side effects of perphenazine and amitriptyline combination. The perphenazine and amitriptyline combination must be used with caution in children with depression. Studies have shown occurrences of children thinking about suicide or attempting suicide in clinical trials for this medicine. More study is needed to be sure the perphenazine and amitriptyline combination is safe and effective in children Geriatric Confusion, vision problems, dizziness or fainting, drowsiness, dryness of mouth, constipation, problems in urinating, trembling of the hands and fingers, and symptoms of tardive dyskinesia (such as uncontrolled movements of the mouth, tongue, jaw, arms, and/or legs) are especially likely to occur in elderly patients. Older patients are usually more sensitive than younger adults to the effects of perphenazine and amitriptyline combination. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Bromopride Cisapride Clorgyline Dronedarone Droperidol Furazolidone Grepafloxacin Iproniazid Isocarboxazid Levomethadyl Linezolid Mesoridazine Methylene Blue Metoclopramide Moclobemide Nialamide Pargyline Phenelzine Pimozide Piperaquine Procarbazine Ranolazine Safinamide Saquinavir Selegiline Sparfloxacin Terfenadine Thioridazine Toloxatone Tranylcypromine Ziprasidone Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acecainide Aceclofenac Acemetacin Albuterol Alfentanil Alfuzosin Almotriptan Amiodarone Amisulpride Amoxapine Amphetamine Amtolmetin Guacil Anagrelide Apomorphine Aprindine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Artemether Asenapine Aspirin Astemizole Atazanavir Azimilide Azithromycin Benzphetamine Bretylium Bromazepam Bromfenac Brompheniramine Bufexamac Buprenorphine Bupropion Buserelin Buspirone Butorphanol Celecoxib Chloral Hydrate Chloroquine Chlorpheniramine Chlorpromazine Choline Salicylate Ciprofloxacin Citalopram Clarithromycin Clomipramine Clonidine Clonixin Clozapine Cocaine Codeine Crizotinib Cyclobenzaprine Dabrafenib Darunavir Dasatinib Degarelix Delamanid Desipramine Deslorelin Desmopressin Desvenlafaxine Deutetrabenazine Dexibuprofen Dexketoprofen Dextroamphetamine Dextromethorphan Diclofenac Diflunisal Dihydrocodeine Dipyrone Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Doxorubicin Doxorubicin Hydrochloride Liposome Doxylamine Droperidol Droxicam Efavirenz Eletriptan Eliglustat Enflurane Epinephrine Erythromycin Escitalopram Eslicarbazepine Acetate Etilefrine Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fentanyl Fepradinol Feprazone Fingolimod Flecainide Flibanserin Floctafenine Fluconazole Flufenamic Acid Fluoxetine Flurbiprofen Foscarnet Frovatriptan Gatifloxacin Gemifloxacin Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Halothane Histrelin Hydrocodone Hydromorphone Hydroxychloroquine Hydroxytryptophan Hydroxyzine Ibuprofen Ibutilide Iloperidone Imipramine Indomethacin Iobenguane I 123 Isoflurane Isradipine Ivabradine Ketoconazole Ketoprofen Ketorolac Lacosamide Lapatinib Leuprolide Levalbuterol Levofloxacin Levomilnacipran Levorphanol Levothyroxine Lidoflazine Lisdexamfetamine Lithium Lopinavir Lorcainide Lorcaserin Lornoxicam Loxoprofen Lumefantrine Lumiracoxib Meclofenamate Mefenamic Acid Mefloquine Meloxicam Meperidine Methadone Methamphetamine Methoxamine Metrizamide Metronidazole Midodrine Milnacipran Mirtazapine Moricizine Morniflumate Morphine Morphine Sulfate Liposome Moxifloxacin Nabumetone Nafarelin Nalbuphine Naproxen Naratriptan Nefazodone Nefopam Nepafenac Niflumic Acid Nilotinib Nimesulide Nimesulide Beta Cyclodextrin Norepinephrine Norfloxacin Nortriptyline Octreotide Ofloxacin Ondansetron Oxaprozin Oxilofrine Oxycodone Oxymetazoline Oxymorphone Oxyphenbutazone Paliperidone Palonosetron Panobinostat Parecoxib Paroxetine Pasireotide Pazopanib Peginterferon Alfa-2b Pentamidine Pentazocine Periciazine Phenylbutazone Phenylephrine Piketoprofen Pimavanserin Piroxicam Pitolisant Pixantrone Posaconazole Pranoprofen Procainamide Procarbazine Prochlorperazine Proglumetacin Promethazine Propafenone Propoxyphene Propyphenazone Proquazone Protriptyline Quetiapine Quinidine Quinine Rasagiline Remifentanil Ribociclib Risperidone Rizatriptan Rofecoxib Salicylic Acid Salsalate Sematilide Sertindole Sertraline Sevoflurane Sibutramine Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Sodium Salicylate Solifenacin Sorafenib Sotalol Spiramycin Sufentanil Sulfamethoxazole Sulindac Sulpiride Sultopride Sumatriptan Sunitinib Tacrolimus Tapentadol Tedisamil Telavancin Telithromycin Tenoxicam Tetrabenazine Tiaprofenic Acid Tiotropium Tolfenamic Acid Tolmetin Toremifene Tramadol Trazodone Trifluoperazine Trimethoprim Trimipramine Triptorelin Tryptophan Valdecoxib Vandetanib Vardenafil Vasopressin Vemurafenib Venlafaxine Vilanterol Vilazodone Vinflunine Voriconazole Vortioxetine Zolmitriptan Zotepine Zuclopenthixol Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acenocoumarol Aminolevulinic Acid Arbutamine Atomoxetine Belladonna Belladonna Alkaloids Betel Nut Bethanidine Carbamazepine Cimetidine Diazepam Dicumarol Evening Primrose Fluvoxamine Fosphenytoin Galantamine Guanethidine Midodrine Orphenadrine Paroxetine Phenprocoumon Phenylalanine Phenytoin Procyclidine Rifapentine Ritonavir S-Adenosylmethionine St John's Wort Trihexyphenidyl Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Tobacco Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Ethanol Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse Certain side effects such as heat stroke may be more likely to occur Asthma (history of) or other lung disease or Bipolar disorder (manic-depressive illness) or Blood disease or Breast cancer or Difficult urination or Enlarged prostate or Epilepsy or other seizure disorders or Glaucoma or Heart or blood vessel disease or Mental illness (severe) or Parkinson's disease or Stomach or intestinal problems Perphenazine and amitriptyline combination may make the condition worse Kidney disease or Liver disease Higher blood levels of perphenazine and amitriptyline may occur, increasing the chance of side effects Overactive thyroid Perphenazine and amitriptyline combination may cause an increased chance of serious effects on the heart Reye's syndrome There may be an increased chance of unwanted effects on the liver Proper Use of perphenazine and amitriptyline This section provides information on the proper use of a number of products that contain perphenazine and amitriptyline. It may not be specific to Duo-Vil 2-25. Please read with care. To lessen stomach upset, take this medicine immediately after meals or with food, unless your doctor has told you to take it on an empty stomach. Do not take more of this medicine and do not take it more often than your doctor ordered. This is particularly important for elderly patients, since they are more sensitive to the effects of this medicine. Sometimes perphenazine and amitriptyline combination must be taken for several weeks before its full effect is reached. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For certain mental and emotional conditions: Adults At first, 1 tablet taken three or four times a day. Your doctor may increase your dose if needed. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using Duo-Vil 2-25 Your doctor should check your progress at regular visits to allow dose adjustments and help reduce side effects. Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely. This is to prevent side effects and to prevent your condition from becoming worse. Do not take this medicine within two hours of taking antacids or medicine for diarrhea. Taking these products too close together may make this medicine less effective. This medicine will add to the effects of alcohol and other CNS depressants (medicines that cause drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine. Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine. Taking perphenazine and amitriptyline combination together with medicines that are used during surgery or dental or emergency treatments may increase the CNS depressant effects. The perphenazine and amitriptyline combination may cause some people to be agitated, irritable or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away. This medicine may cause some people to become drowsy or less alert than they are normally, especially during the first few weeks of treatment. Even if this medicine is taken only at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert. Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor. This medicine may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine, since overheating may result in heat stroke. Also, hot baths or saunas may make you feel dizzy or faint. Perphenazine and amitriptyline combination may cause dryness of the mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Perphenazine may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine: Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. Wear protective clothing, including a hat. Also, wear sunglasses. Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional. Apply a sun block lipstick that has an SPF of at least 15 to protect your lips. Do not use a sunlamp or tanning bed or booth. If you have a severe reaction from the sun, check with your doctor. Duo-Vil 2-25 Side Effects Along with its needed effects, perphenazine (included in this combination medicine) can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it. Stop taking this medicine and get emergency help immediately if any of the following effects occur: Rare Convulsions (seizures) difficulty in breathing fast heartbeat fever high or low blood pressure increased sweating loss of bladder control muscle stiffness (severe) unusual tiredness or weakness unusually pale skin Check with your doctor as soon as possible if any of the following side effects occur: More common Blurred vision or any change in vision difficulty in speaking or swallowing fainting inability to move eyes lip smacking or puckering loss of balance control mask-like face muscle spasms, especially of face, neck, and back nervousness, restlessness, or need to keep moving puffing of cheeks rapid or fine, worm-like movements of tongue shuffling walk stiffness of arms and legs trembling and shaking of fingers and hands tic-like or twitching movements twisting movements of body uncontrolled chewing movements uncontrolled movements of arms or legs weakness of arms and legs Less common Confusion constipation difficult urination eye pain hallucinations (seeing, hearing, or feeling things that are not there) increased skin sensitivity to sun shakiness slow pulse or irregular heartbeat Rare Abdominal or stomach pain aching muscles or joints back or leg pain fever and chills hair loss hot, dry skin or lack of sweating irritability loss of appetite muscle weakness or twitching nausea, vomiting, or diarrhea nosebleeds prolonged, painful, inappropriate penile erection ringing, buzzing, or other unexplained noises in ears skin discoloration skin rash and itching sore throat and fever swelling of face and tongue swelling of testicles unusual bleeding or bruising yellow eyes or skin Symptoms of overdose Agitation confusion convulsions (seizures) drowsiness (severe) enlarged pupils fast, slow, or irregular heartbeat fever hallucinations (seeing, hearing, or feeling things that are not there) shortness of breath or troubled breathing unusual tiredness or weakness (severe) vomiting (severe) Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Decreased sweating dizziness drowsiness dryness of mouth headache increased appetite for sweets nasal congestion tiredness or weakness (mild) unpleasant taste weight gain (unusual) Less common Changes in menstrual period decreased sexual ability heartburn increased sweating swelling or pain in breasts or unusual secretion of milk After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects: Dizziness nausea or vomiting stomach pain trembling of fingers and hands symptoms of tardive dyskinesia, including lip smacking or puckering, puffing of cheeks, rapid or fine, worm-like movements of tongue, uncontrolled chewing movements, or uncontrolled movements of arms or legs After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects: Diarrhea headache irritability restlessness trouble in sleeping, with vivid dreams unusual excitement Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about Duo-Vil (amitriptyline / perphenazine) Side Effects During Pregnancy Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: psychotherapeutic combinations Consumer resources Duo-Vil 2-10 (Advanced Reading) Other brands: Triavil , Etrafon , Etrafon Forte Professional resources Perphenazine Amitriptyline (FDA) Related treatment guides Agitation Anxiety Depression} Drug Status Rx Availability Prescription only N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Drug Class Psychotherapeutic combinations Related Drugs Anxiety Xanax , Lexapro , Cymbalta , atenolol , alprazolam , lorazepam , venlafaxine , duloxetine , More... Agitation olanzapine , loxapine , amitriptyline / perphenazine , Zyprexa Intramuscular , Triavil , Adasuve , More... Depression trazodone , sertraline , Xanax , citalopram , Zoloft , Lexapro , Cymbalta , Celexa , More... 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