a wider variety What is Rexulti? Rexulti is a medication known as an atypical antipsychotic that is used to treat symptoms of schizophrenia. Sometimes Rexulti is also prescribed to treat symptoms of depression when antidepressants alone do not relieve symptoms. When did the U.S. Food and Drug Administration (FDA) approve the medication? Rexulti was first approved by the FDA to treat schizophrenia in 2015. Is there a generic version of Rexulti? No, there is currently no generic version of the drug available for use in the United States. Are there any major differences between Rexulti and other antipsychotics used to treat Rexulti? Rexulti belongs to the class of medications known as atypical antipsychotics or second generation psychotics. Atypical antipsychotics generally have fewer side effects than conventional antipsychotics. Talk to your doctor about what might work best for you and the costs and benefits of taking the medication. Some people may need to try several different antipsychotics before they find the most effective with the fewest side effects. Can children take Rexulti? The effectiveness and safety of the medication has not been tested in patients less than 18 years old. Talk to your child s doctor about the risks of using the medication, which may include increased suicidal thoughts and behaviors among persons 24 and younger. Are there potential interaction issues for people taking Rexulti and any other drugs? There are hundreds of drugs which are known to interact with Rexulti in major, moderate, or mild ways, so let your doctor know what other medications you are taking before you begin taking the medication. Some of these include antidepressants, antifungal medications, blood pressure medication, clarithromycin, quinidine, and rifampin. Are there any other medical conditions that would make someone ineligible for Rexulti therapy? Talk to your doctor about other medical conditions before you take Rexulti, such as dementia, stroke, seizures, neuroleptic malignant syndrome (NMS), diabetes, kidney or liver disease, or tardive dyskinesia. What is the typical dose that would be prescribed to someone taking Rexulti? Typical starting dosage for treating schizophrenia in adults is 1 mg taken once daily. The maximum dose recommended is 4 mg taken once daily. What do I do if I miss a dose? Take the dose of Rexulti when you remember, but skip the missed dose if it it s almost time for your next dose. You should never take extra doses of the medication to make up for missed doses. What common side effects can Rexulti cause? The common side effects of Rexulti can include: Headache Fatigue Heartburn Constipation dizziness Uncontrollable shaking Weight gain It also is recommended that you wait to drive or operate machinery until you know how the medication affects you. Report major side effects to your doctor immediately, which can include shortness of breath, rash or hives, itching, sore throat, fever, confusion, sweating, tightening of neck muscles or throat, swelling, difficulty breathing or swallowing, uncontrollable body movements, or seizures. Persons 24 years and younger are also at increased risk for developing suicidal thoughts and behaviors. You can also report side effects to the FDA at 1-800-FDA-1088 or online . What are the potential long-term effects of taking Rexulti? Your doctor should monitor for progression of potential long-term side effects, which can include tardive dyskinesia (TD). Atypical antipsychotics may also increase the risk of cardiovascular side effects, diabetes, low white blood cell count, weight gain, and high cholesterol. Is it safe for a woman who is pregnant, about to become pregnant, or nursing to take Rexulti? There have been no controlled human pregnancy studies on the effects of Rexulti, but there is a risk for withdrawal symptoms in a newborn when the mother takes the medication during the third trimester. It is not known whether the drug can be transferred via human breast milk and harm a baby. Therefore, talk to your doctor if you are pregnant, planning to become pregnant, or are nursing before you take Rexulti. Can symptoms occur if Rexulti is discontinued? It s important not to discontinue use of the drug if you feel better. Maintain contact with your doctor and seek medical attention if necessary when discontinuing the drug. Talk to your doctor about how to mitigate potential withdrawal symptoms. What should I do if I overdose on Rexulti? There is limited data available on overdose symptoms, so seek immediate help or call the Poison Help Line at 1-800-222-1222 if you overdose. Is Rexulti habit-forming? Rexulti has no habit-forming potential, but it is not recommended that you discontinue use of the drug before talking with your doctor, as withdrawal symptoms can occur. How much does Rexulti cost? According to goodrx.com, 30 tablets of 2 mg Rexulti cost approximately $1,000. Are there any disadvantages to Rexulti? The biggest disadvantages of Rexulti are potential side effects and the potential long-term side effects, which can include tardive dyskinesia, hyperglycemia, and weight gain, as well as potential suicidal thoughts and behaviors in persons 24 years and younger. DISCLAIMER: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. This article mentions drugs that were FDA-approved and available at the time of publication and may not include all possible drug interactions or all FDA warnings or alerts. The author of this page explicitly does not endorse this drug or any specific treatment method. If you have health questions or concerns about interactions, please check with your physician or go to the FDA [link] site for a comprehensive list of warnings. Article Sources NIH Brexpiprazole FDA Highlights of Prescribing Information Rexulti Last Updated: Sep 28, 2017 it is important
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