the best Vigabatrin use while Breastfeeding Drugs containing Vigabatrin: Sabril Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Vigabatrin Levels and Effects while Breastfeeding Summary of Use during Lactation Limited information indicates that maternal doses of vigabatrin up to 2000 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Until more data are available, vigabatrin should only be used with careful monitoring during breastfeeding. Drug Levels Maternal Levels. Two nursing mothers were each receiving vigabatrin 1000 mg twice daily. One was also taking slow-release carbamazepine 200 mg twice daily. Milk samples were collected once predose and 3 and 6 hours after the dose at either 6 or 8 days postpartum. In both mothers, the inactive R-isomer was excreted into milk in higher concentrations than the active S-isomer. In the 2 mothers, average concentrations of the R-isomer were 1.7 mg/L in the predose sample, 2.1 mg/L at 3 hours and 3.1 mg/L at 6 hours after the dose. Average concentrations of the S-isomer were 0.4 mg/L in the predose sample, 0.4 mg/L at 3 hours and 0.8 mg/L at 6 hours after the dose. Using peak values, the authors estimated that the maximum dosage that the infant would receive in the mothers would be 2 to 3.6% of the weight-adjusted maternal dosage for the R-isomer and 0.6 to 0.96% of the maternal dosage for the S-isomer.[1] Infant Levels. Relevant published information was not found as of the revision date. Effects in Breastfed Infants Relevant published information was not found as of the revision date. Effects on Lactation and Breastmilk Relevant published information was not found as of the revision date. References 1. Tran A, O'Mahoney T, Rey E et al. Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers. Br J Clin Pharmacol. 1998;45:409-11. PMID: 9578192 Vigabatrin Identification Substance Name Vigabatrin CAS Registry Number 60643-86-9 Drug Class Anticonvulsants GABA Agents Administrative Information LactMed Record Number 1003 Last Revision Date 20150310 Disclaimer Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site. Print this page Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy. More about vigabatrin Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: gamma-aminobutyric acid analogs Consumer resources Vigabatrin Vigabatrin Tablets Vigabatrin Oral Solution Vigabatrin (Advanced Reading) Other brands: Sabril Professional resources Vigabatrin (AHFS Monograph) Vigabatrin (FDA) Vigabatrin (Wolters Kluwer) Related treatment guides Epilepsy Seizure Prevention Seizures Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Vigabatrin Rating No Reviews - Be the first! 4.0 /10 No Reviews - Be the first! 4.0 Rate it! Drug Class Gamma-aminobutyric acid analogs impasse
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