premiere dasabuvir, ombitasvir, paritaprevir, and ritonavir (Oral route) da-SA-bue-vir, om-BIT-as-vir, par-i-TA-pre-vir, rit-OH-na-vir Oral route(Tablet, Extended Release) Test all patients for evidence of current or prior hepatitis B virus (HBV) infection before initiating treatment with dasabuvir/ombitasvir/paritaprevir/ritonavir. HBV reactivation has been reported in HCV/HBV coinfected patients who were undergoing or had completed treatment with HCV direct acting antivirals and were not receiving HBV antiviral therapy. Some cases have resulted in fulminant hepatitis, hepatic failure, and death. Monitor HCV/HBV coinfected patients for hepatitis flare or HBV reactivation during HCV treatment and post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Viekira XR Available Dosage Forms: Tablet, Extended Release Therapeutic Class: Antiviral Pharmacologic Class: Hepatitis C Virus NS5A Inhibitor Slideshow Oral Hepatitis C Treatments: The Evolving Landscape Uses For dasabuvir, ombitasvir, paritaprevir, and ritonavir Dasabuvir, ombitasvir, paritaprevir, and ritonavir combination is used with or without ribavirin to treat chronic hepatitis C infection, including patients with compensated cirrhosis. dasabuvir, ombitasvir, paritaprevir, and ritonavir is available only with your doctor's prescription. Before Using dasabuvir, ombitasvir, paritaprevir, and ritonavir In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dasabuvir, ombitasvir, paritaprevir, and ritonavir, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to dasabuvir, ombitasvir, paritaprevir, and ritonavir or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of Viekira XR in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Viekira XR in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking dasabuvir, ombitasvir, paritaprevir, and ritonavir, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using dasabuvir, ombitasvir, paritaprevir, and ritonavir with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Abiraterone Alfuzosin Amifampridine Amiodarone Amisulpride Astemizole Atorvastatin Bepridil Carbamazepine Cisapride Colchicine Conivaptan Crizotinib Dihydroergotamine Dronedarone Efavirenz Elbasvir Eletriptan Encainide Enzalutamide Eplerenone Ergoloid Mesylates Ergonovine Ergotamine Ethinyl Estradiol Etravirine Everolimus Flecainide Flibanserin Fluconazole Fosphenytoin Gemfibrozil Grazoprevir Isavuconazonium Sulfate Ivabradine Lomitapide Lovastatin Lurasidone Maraviroc Mesoridazine Methylergonovine Methysergide Midazolam Mitotane Naloxegol Nelfinavir Nevirapine Nimodipine Phenobarbital Phenytoin Pimozide Piperaquine Primidone Propafenone Quinidine Ranolazine Rifampin Riociguat Romidepsin Sildenafil Silodosin Simvastatin Sirolimus Sparfloxacin St John's Wort Tacrolimus Terfenadine Thioridazine Tolvaptan Triazolam Venetoclax Voriconazole Ziprasidone Using dasabuvir, ombitasvir, paritaprevir, and ritonavir with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Ado-Trastuzumab Emtansine Afatinib Alprazolam Amiodarone Amprenavir Anagrelide Apixaban Aprepitant Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Artemether Ataluren Atazanavir Avanafil Axitinib Bedaquiline Bepridil Betrixaban Boceprevir Bosentan Bosutinib Brexpiprazole Brigatinib Bromocriptine Budesonide Bupropion Buserelin Cabazitaxel Cabozantinib Calcifediol Cariprazine Ceritinib Cilostazol Cladribine Clarithromycin Clozapine Cobicistat Cobimetinib Conivaptan Conjugated Estrogens Cyclophosphamide Cyclosporine Dabigatran Etexilate Dabrafenib Daclatasvir Dactinomycin Darunavir Dasatinib Daunorubicin Deferasirox Deflazacort Degarelix Delamanid Deslorelin Deutetrabenazine Dexamethasone Digoxin Disopyramide Docetaxel Dolutegravir Domperidone Donepezil Doxorubicin Doxorubicin Hydrochloride Liposome Eluxadoline Enzalutamide Erlotinib Escitalopram Eszopiclone Etoposide Etravirine Fentanyl Flecainide Fluoxetine Fluticasone Folic Acid Fosamprenavir Fosaprepitant Foscarnet Furosemide Fusidic Acid Garlic Gonadorelin Goserelin Histrelin Hydrocodone Hydroxychloroquine Hydroxyzine Ibrutinib Idelalisib Ifosfamide Iloperidone Irinotecan Irinotecan Liposome Ivacaftor Ivermectin Ixabepilone Ketoconazole Lacosamide Lamivudine Lapatinib Leuprolide Levofloxacin Levomilnacipran Lidocaine Lopinavir Macitentan Manidipine Metformin Methadone Methotrexate Methylenedioxymethamphetamine Metronidazole Mexiletine Midostaurin Mifepristone Montelukast Morphine Morphine Sulfate Liposome Moxifloxacin Nafarelin Netupitant Nifedipine Nilotinib Nitrofurantoin Olaparib Omeprazole Ondansetron Orlistat Oxaliplatin Oxycodone Palbociclib Panobinostat Pasireotide Pazopanib Pimavanserin Pitolisant Pixantrone Ponatinib Posaconazole Pravastatin Prednisolone Prednisone Propafenone Quercetin Quetiapine Quinidine Quinine Reboxetine Regorafenib Retapamulin Ribociclib Rifabutin Rifapentine Rilpivirine Riluzole Rivaroxaban Rosuvastatin Ruxolitinib Salmeterol Sertraline Sevoflurane Simeprevir Sonidegib Sorafenib Sotalol Sulpiride Sumatriptan Sunitinib Suvorexant Tacrolimus Tadalafil Tamoxifen Tamsulosin Temsirolimus Teniposide Testosterone Thiotepa Ticagrelor Topotecan Toremifene Trabectedin Triamcinolone Triptorelin Valbenazine Vandetanib Vemurafenib Venlafaxine Vilanterol Vilazodone Vinblastine Vincristine Vincristine Sulfate Liposome Vinflunine Vorapaxar Voriconazole Zolpidem Zuclopenthixol Using dasabuvir, ombitasvir, paritaprevir, and ritonavir with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acenocoumarol Amitriptyline Amprenavir Cerivastatin Clonazepam Dalfopristin Delavirdine Desipramine Desogestrel Didanosine Dienogest Disopyramide Drospirenone Dutasteride Estradiol Cypionate Estradiol Valerate Ethynodiol Diacetate Etonogestrel Fosamprenavir Imipramine Indinavir Itraconazole Lamotrigine Levonorgestrel Levothyroxine Medroxyprogesterone Acetate Meperidine Mestranol Methamphetamine Mexiletine Nefazodone Norelgestromin Norethindrone Norgestimate Norgestrel Olanzapine Opicapone Paroxetine Prasugrel Quinupristin Risperidone Tenofovir Disoproxil Fumarate Theophylline Trazodone Valproic Acid Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using dasabuvir, ombitasvir, paritaprevir, and ritonavir with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use dasabuvir, ombitasvir, paritaprevir, and ritonavir, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of dasabuvir, ombitasvir, paritaprevir, and ritonavir. Make sure you tell your doctor if you have any other medical problems, especially: Hepatitis B, history of Use with caution. May cause this condition to become active again. HIV infection Use with caution. May make this condition worse. Liver disease, moderate to severe Should not be used in patients with this condition. Proper Use of dasabuvir, ombitasvir, paritaprevir, and ritonavir To help clear up your infection completely, Viekira XR may or may not be taken together with ribavirin, for the full time of treatment , even if you begin to feel better after a few days. Also, it is important to keep the amount of medicine in your body at a steady level. To help keep the amount constant, Viekira XR must be used on a regular schedule. dasabuvir, ombitasvir, paritaprevir, and ritonavir should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions. Swallow the extended-release tablet whole. Do not crush, break, or chew it. Take dasabuvir, ombitasvir, paritaprevir, and ritonavir with food. Do not drink alcohol within 4 hours of taking Viekira XR . Dosing The dose of dasabuvir, ombitasvir, paritaprevir, and ritonavir will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dasabuvir, ombitasvir, paritaprevir, and ritonavir. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (extended-release tablets): For chronic hepatitis C virus infection, with or without ribavirin: Adults 3 tablets taken once a day. Each tablet contains 200 mg of dasabuvir, 8.33 mg of ombitasvir, 50 mg of paritaprevir, and 33.33 mg of ritonavir. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of dasabuvir, ombitasvir, paritaprevir, and ritonavir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using dasabuvir, ombitasvir, paritaprevir, and ritonavir It is very important that your doctor check your progress at regular visits to make sure dasabuvir, ombitasvir, paritaprevir, and ritonavir is working properly. Blood tests may be needed to check for unwanted effects. Using dasabuvir, ombitasvir, paritaprevir, and ritonavir together with ribavirin while you are pregnant can harm your unborn baby. These medicines may also cause birth defects if the father is using it when his sexual partner is pregnant. Avoid pregnancy during combination treatment with dasabuvir, ombitasvir, paritaprevir, and ritonavir and ribavirin for 6 months of stopping treatment. If a pregnancy occurs while you are using these medicines, tell your doctor right away. Do not use the following medicines while you are using dasabuvir, ombitasvir, paritaprevir, and ritonavir: alfuzosin (Uroxatral ), cisapride (Propulsid ), colchicine (Colcrys ), dronedarone (Multaq ), efavirenz (Sustiva ), ethinyl estradiol (Norinyl , Ortho Evra ), everolimus (Afinitor ), gemfibrozil (Lopid ), lurasidone (Latuda ), oral midazolam (Versed ), pimozide (Orap ), ranolazine (Ranexa ), rifampin (Rifadin , Rimactane ), sildenafil (Revatio ), sirolimus (Rapamune ), St. John's wort, tacrolimus (Prograf ), triazolam (Halcion ), certain medicines to lower cholesterol (such as atorvastatin, lovastatin, simvastatin, Mevacor , Zocor ), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Tegretol ), or ergot medicines (such as dihydroergotamine, ergotamine, methylergonovine, Cafergot , Ergomar , Wigraine ). Using Viekira XR with any of these medicines can cause very serious medical problems . Check with your doctor right away if you are weak or tired, have onset of confusion, have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. dasabuvir, ombitasvir, paritaprevir, and ritonavir Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Incidence not known Blistering, peeling, or loosening of the skin chills cough dark-colored urine diarrhea general feeling of tiredness or weakness headache itching joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools nausea red skin lesions, often with a purple center red, irritated eyes sore throat sores, ulcers, or white spots in the mouth or on the lips stomach pain, continuing unusual tiredness or weakness vomiting yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Blistering, crusting, irritation, itching, or reddening of the skin cracked, dry, scaly skin hives or welts, or skin rash increased sensitivity of the skin to sunlight lack or loss of strength redness or other discoloration of the skin severe sunburn swelling trouble sleeping Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about dasabuvir/ombitasvir/paritaprevir/ritonavir Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 10 Reviews Add your own review/rating Drug class: antiviral combinations Consumer resources Dasabuvir, ombitasvir, paritaprevir, and ritonavir Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Tablets Ombitasvir, paritaprevir, ritonavir and dasabuvir (Advanced Reading) Other brands: Viekira Pak , Viekira XR Professional resources Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir (AHFS Monograph) Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir (Wolters Kluwer) Related treatment guides Hepatitis C} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Drug Class Antiviral combinations Related Drugs Hepatitis C Harvoni , Epclusa , ribavirin , Zepatier , Mavyret , Sovaldi , sofosbuvir , ledipasvir / sofosbuvir , Viekira Pak , Vosevi , daclatasvir , Daklinza , Pegasys , Intron A , Ribasphere , Olysio , sofosbuvir / velpatasvir , Rebetol , simeprevir , Moderiba , PegIntron , glecaprevir / pibrentasvir , elbasvir / grazoprevir , More... Dasabuvir / ombitasvir / paritaprevir / ritonavir Rating 10 User Reviews 6.9 /10 10 User Reviews 6.9 Rate it! Help and Support Looking for answers? Ask a question or go join the dasabuvir / ombitasvir / paritaprevir / ritonavir support group to connect with others who have similar interests.} } today
beneficial properties element dasabuvir, ombitasvir, paritaprevir, and ritonavir (Oral route) work from home
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