getting back from darunavir and cobicistat (Oral route) dar-UE-na-vir, koe-BIK-i-stat Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Prezcobix Available Dosage Forms: Tablet Therapeutic Class: Antiretroviral Agent Pharmacologic Class: Protease Inhibitor Slideshow 2016 New Drug Approvals: The Year That Was Uses For darunavir and cobicistat Darunavir and cobicistat combination is used together with other medicines to treat human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Darunavir and cobicistat combination will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. darunavir and cobicistat will not keep you from spreading HIV to other people. People who receive darunavir and cobicistat may continue to have other problems usually related to AIDS or HIV disease. darunavir and cobicistat is available only with your doctor's prescription. Before Using darunavir and cobicistat In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For darunavir and cobicistat, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to darunavir and cobicistat or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of darunavir and cobicistat combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of atazanavir and cobicistat combination in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require caution for patients receiving darunavir and cobicistat. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking darunavir and cobicistat, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using darunavir and cobicistat with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Alfuzosin Astemizole Carbamazepine Cisapride Colchicine Conivaptan Crizotinib Dihydroergotamine Domperidone Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Eletriptan Eliglustat Eplerenone Ergonovine Ergotamine Fosphenytoin Grazoprevir Isavuconazonium Sulfate Ivabradine Lomitapide Lovastatin Lurasidone Maraviroc Methylergonovine Midazolam Naloxegol Pazopanib Phenobarbital Phenytoin Pimozide Primidone Ranolazine Rifampin Riociguat Romidepsin Sildenafil Silodosin Simvastatin St John's Wort Terfenadine Tolvaptan Triazolam Venetoclax Using darunavir and cobicistat with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Ado-Trastuzumab Emtansine Afatinib Alprazolam Amineptine Amiodarone Amitriptyline Amitriptylinoxide Amobarbital Amoxapine Amprenavir Apixaban Aprepitant Aprobarbital Aripiprazole Atazanavir Atomoxetine Atorvastatin Avanafil Bedaquiline Betrixaban Boceprevir Bosentan Bosutinib Brigatinib Bromocriptine Budesonide Butabarbital Butalbital Cabazitaxel Cabozantinib Calcifediol Cariprazine Ceritinib Cilostazol Clarithromycin Clomipramine Cobimetinib Codeine Conivaptan Cyclophosphamide Cyclosporine Dabigatran Etexilate Dabrafenib Daclatasvir Dasabuvir Dasatinib Deflazacort Delamanid Delavirdine Desipramine Desogestrel Dexamethasone Dextromethorphan Diazepam Dibenzepin Didanosine Dienogest Digoxin Disopyramide Docetaxel Domperidone Donepezil Doxepin Doxorubicin Doxorubicin Hydrochloride Liposome Drospirenone Duloxetine Efavirenz Eliglustat Elvitegravir Erlotinib Erythromycin Eslicarbazepine Acetate Estradiol Cypionate Estradiol Valerate Eszopiclone Ethinyl Estradiol Ethynodiol Diacetate Etonogestrel Etravirine Everolimus Fentanyl Flecainide Fluoxetine Fluticasone Fluvastatin Fosamprenavir Fosaprepitant Gestodene Haloperidol Hydrocortisone Ibrutinib Idelalisib Ifosfamide Iloperidone Imipramine Irinotecan Irinotecan Liposome Itraconazole Ivacaftor Ketoconazole Lapatinib Levomilnacipran Levonorgestrel Lidocaine Lofepramine Lopinavir Lumacaftor Macitentan Manidipine Medroxyprogesterone Acetate Melitracen Mephobarbital Mestranol Methadone Methohexital Mexiletine Midostaurin Mifepristone Modafinil Morphine Morphine Sulfate Liposome Nafcillin Naloxegol Nelfinavir Netupitant Nevirapine Nifedipine Nilotinib Nimodipine Nisoldipine Norelgestromin Norethindrone Norgestimate Norgestrel Nortriptyline Olaparib Ombitasvir Ondansetron Opipramol Orlistat Oxcarbazepine Oxycodone Palbociclib Panobinostat Paritaprevir Pentobarbital Perphenazine Pimavanserin Piperaquine Pitavastatin Pixantrone Ponatinib Pravastatin Prednisolone Prednisone Primidone Propafenone Propranolol Protriptyline Quetiapine Quinidine Reboxetine Regorafenib Retapamulin Ribociclib Rifabutin Rifapentine Ritonavir Rivaroxaban Rosuvastatin Ruxolitinib Salmeterol Saquinavir Secobarbital Simeprevir Sirolimus Sunitinib Suvorexant Tacrolimus Tadalafil Tamoxifen Tamsulosin Telaprevir Telithromycin Temsirolimus Thiopental Thiotepa Tianeptine Ticagrelor Tipranavir Topotecan Toremifene Trabectedin Tramadol Trazodone Trimipramine Valbenazine Vardenafil Vemurafenib Venlafaxine Vilanterol Vilazodone Vinblastine Vincristine Vincristine Sulfate Liposome Vinflunine Vorapaxar Voriconazole Warfarin Zolpidem Using darunavir and cobicistat with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aripiprazole Lauroxil Atazanavir Clarithromycin Cobicistat Darunavir Digoxin Indinavir Ketoconazole Nelfinavir Tenofovir Disoproxil Fumarate Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of darunavir and cobicistat. Make sure you tell your doctor if you have any other medical problems, especially: Diabetes or Fanconi syndrome (kidney disease), history of or Hemophilia (a bleeding problem) or Hyperglycemia (high blood sugar) or Kidney failure, history of or Liver disease (including hepatitis B or C) or Sulfa allergy Use with caution. May make these conditions worse. Liver disease, severe Use is not recommended in these patients. Proper Use of darunavir and cobicistat Take darunavir and cobicistat exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. darunavir and cobicistat comes with a patient information leaflet. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. You should talk to your doctor if you have any questions. Do not change the dose or stop using darunavir and cobicistat without checking first with your doctor . When your supply of darunavir and cobicistat is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of darunavir and cobicistat. If you are also using didanosine (Videx ), take it 1 hour before or 2 hours after taking Prezcobix . Darunavir and cobicistat contains a fixed amount of medicine in each tablet. Dosing The dose of darunavir and cobicistat will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of darunavir and cobicistat. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For treatment of HIV infection: Adults One tablet once a day with food. Each tablet contains 800 milligrams (mg) of darunavir and 150 mg of cobicistat. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of darunavir and cobicistat, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose by more than 12 hours, skip that dose and take the next dose at the regular time. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using darunavir and cobicistat Your doctor will want to check your progress at regular visits , especially during the first few weeks that you take darunavir and cobicistat. Blood and urine tests may be needed to check for any unwanted effects. darunavir and cobicistat should not be used together with alfuzosin (Uroxatral ), carbamazepine (Tegretol ), cisapride (Propulsid ), colchicine (Colcrys ), dronedarone (Multaq ), elbasvir/grazoprevir (Zepatier ), lovastatin (Mevacor ), lurasidone (Latuda ), midazolam (Versed ), phenobarbital (Luminal ), phenytoin (Dilantin ), pimozide (Orap ), ranolazine (Ranexa ), rifampin (Rifadin , Rimactane ), sildenafil (Revatio ), simvastatin (Zocor ), St John's wort, triazolam (Halcion ), or ergot medicines (such as dihydroergotamine, ergotamine, methylergonovine, Cafergot , Ergomar , Wigraine ). Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. Serious skin reactions can occur with darunavir and cobicistat. Check with your doctor right away if you have any of the following symptoms while using darunavir and cobicistat: severe rash, blistering, peeling, or loose skin, chills, cough, diarrhea, itching, joint or muscle pain, red skin lesions, often with a purple center, skin rash, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness. darunavir and cobicistat may increase blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests. darunavir and cobicistat may cause you to have excess body fat. Tell your doctor if you notice changes in your body shape, such as an increased amount of fat in the upper back and neck, or around the chest and stomach area. You might also lose fat from the legs, arms, and face. Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis. Autoimmune disorders (such as Graves' disease, polymyositis, and Guillain-Barré syndrome) may also occur. darunavir and cobicistat does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contaminated blood. Make sure you understand and practice safe sex, even if your partner also has HIV. Avoid sharing needles with anyone. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. darunavir and cobicistat Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare Blistering, peeling, or loosening of the skin chills cough diarrhea itching joint or muscle pain red skin lesions, often with a purple center red, irritated eyes sore throat sores, ulcers, or white spots in the mouth or on the lips unusual tiredness or weakness Incidence not known Abdominal or stomach pain or tenderness agitation clay colored stools coma confusion dark urine decreased appetite decreased urine output depression dizziness fever headache hostility irritability lethargy loss of appetite muscle twitching nausea and vomiting rapid weight gain seizures skin rash stupor swelling of the face, ankles, or hands swelling of the feet or lower legs yellow eyes or skin Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about cobicistat/darunavir Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 3 Reviews Add your own review/rating Drug class: antiviral combinations Consumer resources Cobicistat and darunavir Darunavir and Cobicistat Other brands: Prezcobix Professional resources Darunavir and Cobicistat (Wolters Kluwer) Related treatment guides HIV Infection} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antiviral combinations Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , abacavir , tenofovir , Reyataz , Epzicom , ritonavir , Complera , emtricitabine , darunavir , Kaletra , Intelence , Sustiva , Epivir , efavirenz , nevirapine , atazanavir , raltegravir , Selzentry , More... 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