at once Clemastine use while Breastfeeding Drugs containing Clemastine: Tavist, Tavist-D, 12 Hour Allergy Relief, Dayhist-D, Tavist Allergy/Sinus/Headache, Dayhist-1, Leader Allerhist, Allerhist-1, Tavist-1, Dailyhist-1, Show all 14 Contac 12 Hour Allergy, Tavist Allergy, Dayhist Allergy, Allerhist-D Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Clemastine Levels and Effects while Breastfeeding Summary of Use during Lactation Small occasional doses of clemastine are acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives. Drug Levels Maternal Levels. The milk clemastine level was 5 to 10 mcg/L 20 hours after the last dose in a 1 mg twice daily regimen in one woman. A simultaneous serum level was 20 mcg/L.[1] Infant Levels. Relevant published information was not found as of the revision date. Effects in Breastfed Infants In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to clemastine.[2] A 10-week-old breastfed infant whose mother was taking clemastine, phenytoin and carbamazepine was drowsy, refused to feed, was irritable, and had high-pitched crying.[1] These side effects were possibly caused by clemastine in breastmilk, but the other drugs could also have contributed. Effects on Lactation and Breastmilk Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. Alternate Drugs to Consider Desloratadine , Fexofenadine , Loratadine References 1. Kok TH, Taitz LS, Bennett MJ et al. Drowsiness due to clemastine transmitted in breast milk. Lancet. 1982;1:914-5. Letter. PMID: 6122135 2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418 3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731 4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996 Clemastine Identification Substance Name Clemastine CAS Registry Number 15686-51-8 Drug Class Antihistamines Administrative Information LactMed Record Number 71 Last Revision Date 20150310 Disclaimer Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site. Print this page Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy. More about clemastine Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 2 Reviews Add your own review/rating Drug class: antihistamines Consumer resources Clemastine Clemastine Tablets Clemastine Syrup Other brands: Tavist , Allerhist-1 , Tavist Allergy , Tavist-1 Professional resources Clemastine Fumarate (AHFS Monograph) ... +3 more Related treatment guides Allergic Rhinitis Allergic Reactions Urticaria Drug Status Rx OTC Availability Rx and/or OTC B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Clemastine Rating 2 User Reviews 8.0 /10 2 User Reviews 8.0 Rate it! Drug Class Antihistamines seems
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