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which are eltrombopag (Oral route) el-TROM-boe-pag Oral route(Powder for Suspension;Tablet) In patients with chronic hepatitis C, eltrombopag in combination with interferon and ribavirin may increase the risk of hepatic decompensation. Eltrombopag may increase the risk of severe and potentially life-threatening hepatotoxicity; hepatic function should be monitored and therapy discontinued if necessary . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Promacta Available Dosage Forms: Tablet Powder for Suspension Therapeutic Class: Hematopoietic Slideshow Treatment of Opioid-Induced Constipation: The Hard Facts Uses For eltrombopag Eltrombopag is used to treat thrombocytopenia (low platelets in the blood) in adults and children 1 year of age and older with a blood disorder called chronic idiopathic thrombocytopenic purpura (ITP). eltrombopag is used after a splenectomy (surgery to remove the spleen) and other medicines, such as steroids or immunoglobulin, have not worked well enough. Eltrombopag is also used to treat thrombocytopenia in patients with chronic hepatitis C, along with interferon therapy. Platelets help clot the blood, so a person with thrombocytopenia may have bleeding problems. Eltrombopag works by stimulating the bone marrow to produce more platelets. Eltrombopag is also used to treat severe aplastic anemia (SAA) in patients who have received other medicines to treat SAA, when those medications did not work well. eltrombopag is available only with your doctor's prescription. Before Using eltrombopag In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For eltrombopag, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to eltrombopag or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Safety and efficacy have not been established to treat ITP in children younger than 1 years of age, or in children with thrombocytopenia associated with chronic hepatitis C or with severe aplastic anemia. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of eltrombopag in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require caution or an adjustment in the dose for patients receiving eltrombopag. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking eltrombopag, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using eltrombopag with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Grazoprevir Using eltrombopag with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aluminum Calcium Ciprofloxacin Eluxadoline Fluvoxamine Gemfibrozil Iron Magnesium Mexiletine Pixantrone Propafenone Selenium Simvastatin Topotecan Trimethoprim Zileuton Zinc Using eltrombopag with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atorvastatin Doxorubicin Doxorubicin Hydrochloride Liposome Fluvastatin Levothyroxine Lopinavir Methotrexate Nateglinide Penicillin G Pravastatin Repaglinide Rifampin Rosuvastatin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using eltrombopag with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use eltrombopag, or give you special instructions about the use of food, alcohol, or tobacco. Calcium Rich Food Dairy Food Tobacco Other Medical Problems The presence of other medical problems may affect the use of eltrombopag. Make sure you tell your doctor if you have any other medical problems, especially: Antiphospholipid syndrome or ATIII deficiency or Factor V Leiden (blood clotting disorder) or Liver disease, severe Use with caution. May increase risk for blood clotting problems (eg, thromboembolism). Bleeding problems or Blood clots, history of or Cataracts, history of or Liver disease (including cirrhosis) Use with caution. May make these conditions worse. Liver disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of eltrombopag Take eltrombopag only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Tell your doctor if you have Asian relatives, such as Filipino, Chinese, Japanese, Korean, or Taiwanese. You may need a lower dose of eltrombopag. eltrombopag comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. It is best to take eltrombopag on an empty stomach, or at least 1 hour before or 2 hours after a meal. If you are taking antacids, multivitamins, or other products (such as dairy products or juices) that contain aluminum, calcium, iron, magnesium, selenium, or zinc, take these at least 4 hours before or 2 hours after eltrombopag . Swallow the tablet whole. Do not crush, break, or chew it. Do not mix it with food or liquids. If you are using the oral suspension : Mix the powder with water only. Do not use hot water to mix it. After mixing, take it immediately. Use the dosing syringe that comes with the package. The average household teaspoon may not hold the right amount of liquid. Dosing The dose of eltrombopag will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of eltrombopag. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage forms (suspension or tablets): For severe aplastic anemia: Adults At first, 50 milligrams (mg) once a day. Some patients may start at a lower dose. Your doctor may adjust your dose if needed. However, the dose is usually not more than 150 mg per day. Children Use and dose must be determined by your doctor. For thrombocytopenia with ITP: Adults and children 6 years of age and older At first, 50 milligrams (mg) once a day. Some patients may start at a lower dose. Your doctor may adjust your dose if needed. However, the dose is usually not more than 75 mg per day. Children 1 to 5 years of age At first, 25 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 75 mg per day. Children younger than 1 year of age Use and dose must be determined by your doctor. For thrombocytopenia with chronic hepatitis C: Adults At first, 25 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 100 mg per day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of eltrombopag, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Throw away any unused liquid within 30 minutes of mixing it. Precautions While Using eltrombopag It is very important that your doctor check your progress at regular visits to make sure eltrombopag is working properly. Blood tests will be needed while you are using eltrombopag. Eltrombopag may cause or increase the risk for serious liver problems. Check with your doctor right away if you start having nausea or vomiting, dark urine, light-colored stools, right upper stomach pain, unusual tiredness, or yellow eyes or skin while you are using eltrombopag. Blood clotting problems may occur while you are using eltrombopag. Check with your doctor right away if you have pain, swelling, or tenderness in your leg, or shortness of breath and pain in your chest. Do not stop taking eltrombopag without checking first with your doctor . Your doctor will check your platelet levels and progress when you stop taking the medicine. eltrombopag may cause cataracts or make them worse. Check with your doctor right away if you have blurred vision, difficulty in reading, or any other change in vision while you are taking eltrombopag. Your doctor may want your eyes to be checked by an ophthalmologist (eye doctor). Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. eltrombopag Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bloating or swelling of the face, arms, hands, lower legs, or feet body aches or pain chills or fever cough difficulty with breathing headache loss of voice pale skin rapid weight gain runny nose sore throat tingling of the hands or feet troubled breathing with exertion unusual tiredness or weakness unusual weight gain or loss yellow eyes or skin Less common Bladder pain blindness blurred or decreased vision bruising burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings diarrhea general feeling of discomfort or illness hoarseness joint pain lower back or side pain muscle aches and pains nausea pinpoint red spots on the skin redness of the eye shivering sweating tender, swollen glands in the neck trouble sleeping trouble swallowing voice changes vomiting Incidence not known Chest pain pain, redness, or swelling in the legs or arms Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Decreased appetite difficulty with moving hair loss or thinning of the hair itching skin lack or loss of strength muscle aching or cramping muscle pains or stiffness swollen joints Less common Acid or sour stomach back pain belching bone pain dry mouth heartburn indigestion rash stomach discomfort, upset, or pain Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about eltrombopag Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 5 Reviews Add your own review/rating Drug class: platelet-stimulating agents Consumer resources Eltrombopag Eltrombopag Tablets Other brands: Promacta Professional resources Eltrombopag (AHFS Monograph) Eltrombopag (Wolters Kluwer) Related treatment guides Idiopathic Thrombocytopenic Purpura Aplastic Anemia Thrombocytopenia Thrombocytopenia Idiopathic} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Platelet-stimulating agents Related Drugs Idiopathic Thrombocytopenic Purpura prednisone , triamcinolone , dexamethasone , Decadron , Deltasone , cortisone , More... Aplastic Anemia Promacta , Leukine , Atgam , sargramostim , lymphocyte immune globulin, anti-thy (equine) , More... Thrombocytopenia Idiopathic triamcinolone , Promacta , Kenalog-40 , More... Thrombocytopenia prednisone , dexamethasone , Decadron , Deltasone , Promacta , More... Eltrombopag Rating 5 User Reviews 8.0 /10 5 User Reviews 8.0 Rate it! Related Questions & Answers My hepatologist has advised me to procure Eltrombopag to increase platlet count in HCV? Read more questions} } a petroleum


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