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slugging away elvitegravir, cobicistat, emtricitabine, and tenofovir (Oral route) el-vi-TEG-ra-vir, koe-BIK-i-stat, em-trye-SYE-ta-been, ten-OF-oh-vir dye-soe-PROX-il FUE-ma-rate Oral route(Tablet) Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues in combination with other antiretrovirals. The elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate combination is not approved for the treatment of chronic hepatitis B virus (HBV) infection and the safety and efficacy have not been established in patients coinfected with HBV and HIV-1. Severe acute exacerbations of hepatitis B have been reported in patients coinfected with HBV and HIV-1 who have discontinued emtricitabine or tenofovir disoproxil fumarate. Monitor hepatic function upon discontinuation of therapy in patients coinfected with HIV-1 and HBV and follow-up for at least several months thereafter. Anti-hepatitis B therapy may be warranted . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Stribild Available Dosage Forms: Tablet Therapeutic Class: Anti-Infective Agent Pharmacologic Class: Integrase Inhibitor Slideshow Hep C and Harvoni: 11 Facts About Your Treatment Uses For elvitegravir, cobicistat, emtricitabine, and tenofovir Elvitegravir, cobicistat, emtricitabine, and tenofovir combination is used to treat human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). elvitegravir, cobicistat, emtricitabine, and tenofovir is usually given to adult patients who have yet not received any medicine for HIV infection. Elvitegravir, cobicistat, emtricitabine, and tenofovir combination will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. elvitegravir, cobicistat, emtricitabine, and tenofovir will not keep you from spreading HIV to other people. People who receive elvitegravir, cobicistat, emtricitabine, and tenofovir may continue to have other problems usually related to AIDS or HIV disease. elvitegravir, cobicistat, emtricitabine, and tenofovir is available only with your doctor's prescription. Before Using elvitegravir, cobicistat, emtricitabine, and tenofovir In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For elvitegravir, cobicistat, emtricitabine, and tenofovir, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to elvitegravir, cobicistat, emtricitabine, and tenofovir or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of elvitegravir, cobicistat, emtricitabine, and tenofovir combination in children younger than 12 years of age or weighing less than 35 kilograms. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of elvitegravir, cobicistat, emtricitabine, and tenofovir combination in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution for patients receiving elvitegravir, cobicistat, emtricitabine, and tenofovir. Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking elvitegravir, cobicistat, emtricitabine, and tenofovir, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using elvitegravir, cobicistat, emtricitabine, and tenofovir with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Alfuzosin Carbamazepine Cisapride Colchicine Conivaptan Crizotinib Dihydroergotamine Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Eletriptan Eliglustat Eplerenone Ergonovine Ergotamine Fosphenytoin Isavuconazonium Sulfate Ivabradine Lomitapide Lovastatin Lurasidone Maraviroc Methylergonovine Midazolam Naloxegol Pazopanib Phenobarbital Phenytoin Pimozide Primidone Ranolazine Rifampin Riociguat Romidepsin Sildenafil Silodosin Simvastatin St John's Wort Tolvaptan Triazolam Venetoclax Using elvitegravir, cobicistat, emtricitabine, and tenofovir with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Ado-Trastuzumab Emtansine Afatinib Alprazolam Aluminum Carbonate, Basic Aluminum Hydroxide Aluminum Phosphate Amiodarone Amprenavir Apixaban Aprepitant Aripiprazole Atazanavir Avanafil Bedaquiline Betrixaban Boceprevir Bosentan Bosutinib Brigatinib Bromocriptine Budesonide Cabazitaxel Cabozantinib Calcifediol Calcium Carbonate Cariprazine Ceritinib Cilostazol Clarithromycin Cobimetinib Cyclophosphamide Cyclosporine Dabrafenib Daclatasvir Darunavir Dasatinib Deflazacort Delamanid Delavirdine Dexamethasone Diazepam Didanosine Digoxin Dihydroxyaluminum Aminoacetate Dihydroxyaluminum Sodium Carbonate Disopyramide Docetaxel Domperidone Donepezil Erlotinib Erythromycin Eslicarbazepine Acetate Eszopiclone Etravirine Everolimus Fentanyl Flecainide Fluoxetine Fluticasone Fosamprenavir Fosaprepitant Haloperidol Hydrocortisone Ibrutinib Idelalisib Ifosfamide Iloperidone Irinotecan Irinotecan Liposome Itraconazole Ivacaftor Ketoconazole Lapatinib Ledipasvir Levomilnacipran Lidocaine Lopinavir Macitentan Magaldrate Magnesium Carbonate Magnesium Hydroxide Magnesium Oxide Magnesium Trisilicate Manidipine Methadone Mexiletine Midostaurin Mifepristone Morphine Morphine Sulfate Liposome Netupitant Nevirapine Nifedipine Nilotinib Nimodipine Nisoldipine Olaparib Orlistat Oxcarbazepine Oxycodone Palbociclib Panobinostat Pimavanserin Piperaquine Pixantrone Ponatinib Prednisone Propafenone Quetiapine Quinidine Reboxetine Regorafenib Retapamulin Ribociclib Rifabutin Rifapentine Ritonavir Rivaroxaban Rosuvastatin Ruxolitinib Salmeterol Saquinavir Simeprevir Sirolimus Sodium Bicarbonate Sunitinib Suvorexant Tacrolimus Tadalafil Tamoxifen Tamsulosin Telithromycin Temsirolimus Thiotepa Ticagrelor Tipranavir Topotecan Toremifene Trabectedin Tramadol Trazodone Valbenazine Vardenafil Vemurafenib Vilanterol Vilazodone Vinblastine Vincristine Vincristine Sulfate Liposome Vinflunine Vorapaxar Voriconazole Warfarin Zolpidem Using elvitegravir, cobicistat, emtricitabine, and tenofovir with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aripiprazole Lauroxil Atazanavir Darunavir Indinavir Lopinavir Nelfinavir Ritonavir Tipranavir Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of elvitegravir, cobicistat, emtricitabine, and tenofovir. Make sure you tell your doctor if you have any other medical problems, especially: Bone problems (eg, fracture, osteomalacia), history of or Fanconi syndrome (kidney disease), history of or Hepatitis B infection, history of or Kidney failure, history of Use with caution. May make these conditions worse. Kidney disease, moderate to severe or Liver disease, severe Use is not recommended in patients with these conditions. Proper Use of elvitegravir, cobicistat, emtricitabine, and tenofovir Take elvitegravir, cobicistat, emtricitabine, and tenofovir exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. elvitegravir, cobicistat, emtricitabine, and tenofovir comes with a patient information leaflet. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. You should talk to your doctor if you have any questions. elvitegravir, cobicistat, emtricitabine, and tenofovir should be taken with food. Do not change the dose or stop using elvitegravir, cobicistat, emtricitabine, and tenofovir without checking first with your doctor . When your supply of elvitegravir, cobicistat, emtricitabine, and tenofovir is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of elvitegravir, cobicistat, emtricitabine, and tenofovir. If you are taking aluminum or magnesium-containing antacids (eg, Maalox , Mylanta , Tums ), do not take them at the same time that you take elvitegravir, cobicistat, emtricitabine, and tenofovir. It is best to take these medicines at least 2 hours before or after taking Stribild . These medicines may keep Stribild from working properly. Dosing The dose of elvitegravir, cobicistat, emtricitabine, and tenofovir will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of elvitegravir, cobicistat, emtricitabine, and tenofovir. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For treatment of HIV infection: Adults and children 12 years of age and older and weighs at least 35 kilograms (kg) One tablet once a day. Children younger than 12 years of age or weighs less than 35 kg Use and dose must be determined by your doctor. Missed Dose If you miss a dose of elvitegravir, cobicistat, emtricitabine, and tenofovir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Do not use elvitegravir, cobicistat, emtricitabine, and tenofovir if the seal on the bottle is broken or missing. Keep the bottle tightly closed. Keep the medicine in the original bottle that you were given at the pharmacy. Precautions While Using elvitegravir, cobicistat, emtricitabine, and tenofovir Your doctor will want to check your or your child's progress at regular visits , especially during the first few weeks that you take elvitegravir, cobicistat, emtricitabine, and tenofovir. Blood and urine tests may be needed to check for any unwanted effects. The medicines in this combination tablet are also available as Atripla , Complera , Descovy , Emtriva , Genvoya , Odefsey , Truvada , Tybost , Viread , or Vitekta . Do not take the elvitegravir, cobicistat, emtricitabine, and tenofovir combination with any of these medicines . elvitegravir, cobicistat, emtricitabine, and tenofovir should not be used together with adefovir (Hepsera ), alfuzosin (Uroxatral ), carbamazepine (Tegretol ), cisapride (Propulsid ), lamivudine (Combivir , Epivir , Epivir-HBV , Epzicom , Triumeq , Trizivir ), lovastatin (Mevacor ), lurasidone (Latuda ), midazolam (Versed ), phenobarbital (Luminal ), phenytoin (Dilantin ), pimozide (Orap ), rifampin (Rifadin , Rimactane ), ritonavir (Kaletra , Norvir ), sildenafil (Revatio ), simvastatin (Zocor ), triazolam (Halcion ), St John's wort, ergotamine medicines (eg, dihydroergotamine, ergotamine, methylergonovine, Cafergot , Ergomar , Wigraine ), certain other antiviral medications (eg, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir), aminoglycoside antibiotics, or high-dose or multiple NSAID pain medicines. Two rare but serious reactions to elvitegravir, cobicistat, emtricitabine, and tenofovir are lactic acidosis (too much acid in the blood) and liver toxicity. These reactions are more common if you are female, obese, or have been taking anti-HIV medicines for a long time. Call your doctor right away if you or your child have abdominal or stomach pain, nausea, vomiting, decreased appetite, muscle cramping or pain, unusual tiredness or weakness, trouble breathing, or yellow skin or eyes. elvitegravir, cobicistat, emtricitabine, and tenofovir may also increase your risk of developing fractures (broken bones). Ask your doctor about this if you or your child have any concerns. elvitegravir, cobicistat, emtricitabine, and tenofovir does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contaminated blood. Make sure you understand and practice safe sex, even if your partner also has HIV. Avoid sharing needles with anyone. Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you or your child notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis. Autoimmune disorders (such as Graves' disease, polymyositis, and Guillain-Barré syndrome) may also occur. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. elvitegravir, cobicistat, emtricitabine, and tenofovir Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Cloudy urine Incidence not known Abdominal or stomach discomfort or pain bloody urine bone fractures bone pain change in urination convulsions cough dark-colored urine decreased appetite difficulty with swallowing dizziness dry mouth fast or irregular heartbeat fast, shallow breathing fever general feeling of discomfort increased thirst large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools lower back or side pain mood changes muscle pain, cramps, or stiffness nausea, vomiting or diarrhea numbness or tingling in the hands, feet, or lips puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue skin rash, hives, or itching sleepiness swelling of the face, fingers, or lower legs tightness in the chest trouble breathing unusual tiredness or weakness weight gain yellow eyes and skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abnormal dreams headache Less common Bloated full feeling passing gas trouble sleeping unusual drowsiness Incidence not known Chills constipation indigestion lack or loss of strength pains in the stomach, side, or abdomen, possibly radiating to the back Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about cobicistat/elvitegravir/emtricitabine/tenofovir Side Effects During Pregnancy Dosage Information Drug Interactions Support Group 86 Reviews Add your own review/rating Drug class: antiviral combinations Consumer resources Cobicistat, elvitegravir, emtricitabine, and tenofovir Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate Other brands: Stribild Professional resources Elvitegravir, Cobicistat, Emtricitabine, and tenofovir Disoproxil Fumarate (AHFS Monograph) Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate (Wolters Kluwer) Related treatment guides HIV Infection} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antiviral combinations Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , abacavir , tenofovir , Epzicom , Reyataz , ritonavir , Complera , emtricitabine , darunavir , Kaletra , Intelence , Sustiva , Epivir , efavirenz , nevirapine , atazanavir , raltegravir , Selzentry , More... Cobicistat / elvitegravir / emtricitabine / tenofovir Rating 86 User Reviews 9.4 /10 86 User Reviews 9.4 Rate it! Help and Support Looking for answers? Ask a question or go join the cobicistat / elvitegravir / emtricitabine / tenofovir support group to connect with others who have similar interests.} } newest


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