time for supper dasatinib (Oral route) da-SA-ti-nib Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Sprycel Available Dosage Forms: Tablet Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Tyrosine Kinase Inhibitor Slideshow Leukemia Symptoms And Lessons: Is A Solution In Sight? Uses For dasatinib Dasatinib is used to treat different types of leukemia. Leukemia is a type of cancer where the body makes too many abnormal white blood cells. It belongs to the general group of medicines known as antineoplastics or cancer medicines. Dasatinib interferes with the growth of cancer cells, which are eventually destroyed by the body. dasatinib is available only with your doctor's prescription. Before Using dasatinib In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dasatinib, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to dasatinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of dasatinib in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dasatinib in the elderly. However, some elderly patients may be more sensitive than younger adults to the unwanted effects of dasatinib. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking dasatinib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using dasatinib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Cisapride Dronedarone Fluconazole Measles Virus Vaccine, Live Mesoridazine Mumps Virus Vaccine, Live Nelfinavir Pimozide Piperaquine Posaconazole Rotavirus Vaccine, Live Rubella Virus Vaccine, Live Saquinavir Sparfloxacin Thioridazine Varicella Virus Vaccine Ziprasidone Using dasatinib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adenovirus Vaccine Alfuzosin Amiodarone Amitriptyline Amoxapine Anagrelide Apomorphine Aprepitant Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Asenapine Astemizole Atazanavir Azithromycin Bacillus of Calmette and Guerin Vaccine, Live Buserelin Carbamazepine Ceritinib Chloroquine Chlorpromazine Cholera Vaccine, Live Cimetidine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Cobicistat Conivaptan Crizotinib Dabrafenib Degarelix Delamanid Desipramine Deslorelin Deutetrabenazine Dexamethasone Disopyramide Dofetilide Dolasetron Domperidone Donepezil Droperidol Efavirenz Erythromycin Escitalopram Esomeprazole Famotidine Fingolimod Flecainide Fluoxetine Fosaprepitant Foscarnet Fosphenytoin Gatifloxacin Gemifloxacin Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydroxychloroquine Hydroxyzine Ibutilide Idelalisib Iloperidone Imipramine Indinavir Influenza Virus Vaccine, Live Itraconazole Ivabradine Ketoconazole Lansoprazole Lapatinib Leuprolide Levofloxacin Lopinavir Lumacaftor Lumefantrine Mefloquine Methadone Metronidazole Mifepristone Moxifloxacin Nafarelin Nefazodone Nilotinib Nizatidine Norfloxacin Nortriptyline Octreotide Ofloxacin Omeprazole Ondansetron Paliperidone Panobinostat Pantoprazole Pasireotide Pazopanib Phenytoin Pimavanserin Pitolisant Poliovirus Vaccine, Live Procainamide Prochlorperazine Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Rabeprazole Ranitidine Ranolazine Ribociclib Rifabutin Rifampin Ritonavir Salmeterol Sevoflurane Smallpox Vaccine Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol St John's Wort Sulpiride Sunitinib Tacrolimus Telithromycin Tetrabenazine Toremifene Trazodone Trifluoperazine Trimipramine Triptorelin Typhoid Vaccine Vandetanib Vardenafil Vemurafenib Vinflunine Voriconazole Yellow Fever Vaccine Zuclopenthixol Using dasatinib with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aluminum Carbonate, Basic Aluminum Hydroxide Aluminum Phosphate Calcium Calcium Carbonate Dihydroxyaluminum Aminoacetate Dihydroxyaluminum Sodium Carbonate Magaldrate Magnesium Carbonate Magnesium Hydroxide Magnesium Oxide Magnesium Trisilicate Simvastatin Sodium Bicarbonate Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using dasatinib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use dasatinib, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of dasatinib. Make sure you tell your doctor if you have any other medical problems, especially: Anemia or Arrhythmia (heart rhythm problem) or Bleeding problems or Congenital long QT syndrome (heart rhythm problem) or Edema (fluid retention or swelling) or Neutropenia (low white blood cells) or Palpitations (fast heart rate) or Stomach bleeding or Thrombocytopenia (low platelets in the blood) Use with caution. May make these conditions worse. Infection Dasatinib may decrease your body's ability to fight an infection. Lactose intolerance Use with caution. dasatinib contains lactose. Proper Use of dasatinib Take dasatinib exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of unwanted effects. Medicines used to treat cancer are very strong and can have many side effects. Before receiving dasatinib, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment. dasatinib comes with a patient information insert. Follow the instructions carefully. Ask your doctor if you have any questions. You may take dasatinib with or without food. Swallow the tablet whole. Do not break, cut, crush, or chew it. Pregnant women should avoid handling crushed or broken tablets. If a tablet is broken or crushed, wear disposable gloves to avoid exposure to the medicine. If you are taking an antacid (eg, aluminum hydroxide, magnesium hydroxide, Maalox , Rolaids , or Tums ), take it at least 2 hours before or 2 hours after you take dasatinib. Dosing The dose of dasatinib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dasatinib. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For the treatment of chronic phase CML: Adults At first, 100 milligrams (mg) once a day given either in the morning or in the evening. Your doctor may adjust your dose as needed. Children Use and dose must be determined by your doctor. For the treatment of accelerated or blast crisis CML or Ph+ ALL: Adults At first, 140 milligrams (mg) once a day given either in the morning or in the evening. Your doctor may adjust your dose as needed. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of dasatinib, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using dasatinib It is very important that your doctor check your progress at regular visits to make sure that dasatinib is working properly. Blood tests will be needed to check for unwanted effects. Be sure to keep all appointments. Using dasatinib while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for 30 days after your last dose. If you think you have become pregnant while using the medicine, tell your doctor right away. Dasatinib can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding: If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur. Dasatinib may cause fluid retention. Check with your doctor right away if you have a decrease in amount of urine, noisy or rattling breathing, shortness of breath, swelling of the fingers, hands, feet, or lower legs, troubled breathing at rest, or weight gain. dasatinib can cause changes in the heart rhythm, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Check with your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats. Check with your doctor right away if you have the following symptoms: chest discomfort or pain, decreased urine output, fast, irregular or pounding heartbeat, shortness of breath, swelling of the feet or lower legs, troubled breathing, or unusual tiredness or weakness. These could be symptoms of a serious heart problem. Using dasatinib may cause headache, muscle or joint pain, skin rash, or unusual tiredness or weakness. If these symptoms persist and become worse, check with your doctor. dasatinib may increase your risk of having a condition called pulmonary arterial hypertension (high blood pressure in the lungs). This may occur at anytime during treatment with dasatinib. Check with your doctor right away if you have the following symptoms: shortness of breath, troubled breathing, tiredness, or swelling all over your body (fluid retention). Serious skin reactions can occur with dasatinib. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using dasatinib. dasatinib may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness. Do not drink grapefruit juice while you are using dasatinib. Grapefruit juice may change the amount of medicine that is absorbed in the body. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. dasatinib Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bloody or black, tarry stools body aches or pain burning, tingling, numbness or pain in the hands, arms, feet, or legs chest pain constipation cough or hoarseness coughing up blood decrease in the amount of urine dizziness ear congestion fainting fast, slow, or irregular heartbeat fever or chills full or bloated feeling headache loss of voice lower back or side pain nasal congestion noisy or rattling breathing painful or difficult urination pale skin paralysis pressure in the stomach runny nose sensation of pins and needles severe stomach pain sneezing sore throat stabbing pain swelling of the abdominal or stomach area swelling of the face, fingers, hands, feet, or lower legs tightness in the chest troubled breathing ulcers, sores, or white spots in the mouth unsteadiness or awkwardness unusual bleeding or bruising unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds weakness in the arms, hands, legs, or feet weight gain Less common Bloating blue lips and fingernails chest discomfort coughing that sometimes produces a pink frothy sputum decreased urine output difficult or fast breathing dilated neck veins increased sweating irregular breathing irregular heartbeat nausea swelling swelling in the legs and ankles Incidence not known Anxiety pain, redness, or swelling in the arm or leg sudden shortness of breath or troubled breathing tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain bleeding gums cracked lips diarrhea difficulty with moving difficulty with swallowing increased menstrual flow or vaginal bleeding itching skin or rash lack or loss of strength loss of appetite muscle aching or cramping muscle or bone pain muscle stiffness nose bleeds pain pain in the joints prolonged bleeding from cuts red or dark brown urine swollen joints vomiting weight loss Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about dasatinib Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 17 Reviews Add your own review/rating Drug class: BCR-ABL tyrosine kinase inhibitors Consumer resources Dasatinib Other brands: Sprycel Professional resources Dasatinib (AHFS Monograph) Dasatinib (Wolters Kluwer) Related treatment guides Acute Lymphoblastic Leukemia Chronic Myelogenous Leukemia Leukemia} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class BCR-ABL tyrosine kinase inhibitors Related Drugs Chronic Myelogenous Leukemia hydroxyurea , Hydrea , Gleevec , cyclophosphamide , imatinib , Sprycel , Tasigna , cytarabine , More... Acute Lymphoblastic Leukemia methotrexate , Gleevec , mercaptopurine , imatinib , Adriamycin , doxorubicin , Sprycel , More... Leukemia prednisone , triamcinolone , dexamethasone , Decadron , Deltasone , Sprycel , Kenalog-40 , More... Dasatinib Rating 17 User Reviews 8.6 /10 17 User Reviews 8.6 Rate it! Related Questions & Answers What is the dosage most used for Sprycel for 2nd round CML patients? What is the best thing to take with dasatinib for sleeplessness? I'm a cml patient, can I quit taking dasatinib after two years? Read more questions} } the general public
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