employees Somavert Side Effects Generic Name: pegvisomant Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Compare Alternatives Pricing & Coupons Note: This document contains side effect information about pegvisomant. Some of the dosage forms listed on this page may not apply to the brand name Somavert. For the Consumer Applies to pegvisomant: subcutaneous powder for solution Along with its needed effects, pegvisomant (the active ingredient contained in Somavert) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking pegvisomant: More common Bleeding, blistering, burning, coldness, or discoloration of skin at site of injection bloating or swelling of face, arms, hands, lower legs, or feet blurred vision chest pain chills cough dizziness feeling of pressure fever headache hives hoarseness infection, inflammation, itching, or lump at site of injection nervousness lower back or side pain painful or difficult urination pounding in the ears rapid weight gain slow or fast heartbeat tingling of hands or feet unusual weight gain or loss Less common Thickening of the skin Incidence not known Abdominal pain or tenderness clay colored stools dark urine decreased appetite fever itching loss of appetite nausea and vomiting skin rash unusual tiredness or weakness yellow eyes or skin Some side effects of pegvisomant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Accidental injury burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings diarrhea general feeling of discomfort or illness joint pain muscle aches and pains pain pain or tenderness around eyes and cheekbones runny or stuffy nose shivering shortness of breath or troubled breathing sore throat sweating tightness of chest or wheezing trouble sleeping For Healthcare Professionals Applies to pegvisomant: subcutaneous powder for injection Hepatic Hepatic side effects have included abnormal liver function tests (elevations of serum concentrations of alanine aminotransferase and aspartate aminotransferase) in up to 12% of patients treated. [ Ref ] During premarketing clinical studies two patients (0.8%) had elevations of serum concentrations of alanine aminotransferase and aspartate aminotransferase greater than 10 times the upper limit of normal. In both patients, the transaminase elevations normalized after discontinuation of the drug. In other studies, up to 12% of patients experienced abnormal liver function tests. [ Ref ] Immunologic Immunologic side effects have included the development of low titer non-neutralizing antigrowth hormone antibodies. [ Ref ] General General side effects have included infection (23 to 33%), pain (8 to 23%), flu syndrome (12 to 21%), and accidental injury (8 to 18%). [ Ref ] Musculoskeletal Musculoskeletal side effects have included back pain (8%) and chest pain (4%). [ Ref ] Respiratory Respiratory side effects have included sinusitis (8%). [ Ref ] Gastrointestinal Gastrointestinal side effects have included diarrhea (4%) and nausea (8%). [ Ref ] Nervous system Nervous system side effects have included headache (26%), dizziness (8%) and paresthesias (7%). [ Ref ] Cardiovascular Cardiovascular side effects have included hypertension (8%) and peripheral edema (8%). [ Ref ] Local Local side effects have included injection site reactions (11%). [ Ref ] Metabolic Metabolic side effects have included hypercholesterolemia (14%). Lipohypertrophy has been reported in less than 5% of patients following pegvisomant (the active ingredient contained in Somavert) administration. [ Ref ] Hypersensitivity Hypersensitivity reactions have included postmarketing reports of systemic hypersensitivity reactions including anaphylactic reactions, laryngospasm, angioedema, and generalized skin reactions (rash, erythema, pruritus, and urticaria). References 1. van der Lely AJ, Hutson RK, Trainer PJ, et al. "Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist." Lancet 358 (2001): 1754-9 2. "Product Information. Somavert (pegvisomant)." Pharmacia and Upjohn, Kalamazoo, MI. 3. Stewart PM "Pegvisomant: an advance in clinical efficacy in acromegaly." Eur J Endocrinol 148 Suppl 2 (2003): S027-32 Some side effects of Somavert may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA . Next Dosage Print this page More about Somavert (pegvisomant) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Español 1 Review Add your own review/rating Drug class: growth hormone receptor blockers Consumer resources Somavert Somavert (Advanced Reading) Professional resources Somavert (AHFS Monograph) Somavert (FDA) Related treatment guides Acromegaly Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Pfizer Inc. Drug Class Growth hormone receptor blockers Related Drugs Acromegaly octreotide , Sandostatin , bromocriptine , Parlodel , lanreotide , Somatuline Depot , Sandostatin LAR Depot , pegvisomant , Signifor LAR , pasireotide , More... Somavert Rating 1 User Review 1 User Review Not Rated - Be the first! make the leap
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