forty six although the relationship between cumulative doxorubicin liposomal dose and the risk of cardiotoxicity is not known. Anthracycline-induced cardiotoxicity may be delayed (after discontinuation of anthracycline treatment). Assess left ventricular function with echocardiogram or MUGA prior to and during treatment to detect acute changes; monitor after treatment to detect delayed cardiotoxicity. Use in patients with a history of cardiovascular disease only if potential benefits outweigh cardiovascular risk. Palmar-plantar erythrodysesthesia (hand-foot syndrome): Hand-foot syndrome has been reported in patients receiving doxorubicin liposomal. It is usually seen after 2 to 3 treatment cycles most precious
police officers t lower cumulative doses in patients with prior mediastinal irradiation. Myocardial damage may manifest as acute left ventricular failure; cardiotoxicity is defined as a> 20% decrease in resting left ventricular ejection fraction (LVEF) from baseline (if LVEF remained in the normal range) or a >10% decrease from baseline (where LVEF was less than the institutional lower limit of normal). Some patients developed signs/symptoms of heart failure without documented evidence of cardiotoxicity. The risk of cardiomyopathy with doxorubicin is generally proportional to the cumulative exposure you haven't any
EmoticonEmoticon