backlinks Sprix Side Effects Generic Name: ketorolac Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Pricing & Coupons Note: This document contains side effect information about ketorolac. Some of the dosage forms listed on this page may not apply to the brand name Sprix. For the Consumer Applies to ketorolac: injectable, solution, tablet Other dosage forms: nasal spray Along with its needed effects, ketorolac (the active ingredient contained in Sprix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking ketorolac: More common Swelling of face, fingers, lower legs, ankles, and/or feet weight gain (unusual) Less common Bruising (not at place of injection) high blood pressure skin rash or itching small, red spots on skin sores, ulcers, or white spots on lips or in mouth Rare Abdominal or stomach pain, cramping, or burning that is severe bleeding from the rectum or bloody or black, tarry stools bloody or cloudy urine blue lips and fingernails blurred vision of other vision change burning, red, tender, thick, scaly, or peeling skin chest pain convulsions cough or hoarseness dark urine decrease in amount of urine that is sudden fainting fast, irregular, noisy, or troubled breathing fever with severe headache, drowsiness, confusion, and stiff neck or back fever with or without chills or sore throat hallucinations (seeing, hearing, or feeling things that are not there) hearing loss hives increase in amount of urine or urinating often light-colored stools loss of appetite low blood pressure mood changes or unusual behavior muscle cramps or pain nausea, heartburn, or indigestion that is severe and continues nosebleeds pain in lower back and/or side pain, tenderness, or swelling in the upper stomach area painful or difficult urination pale skin puffiness or swelling of the eyelids or eyes ringing or buzzing in ears runny nose severe restlessness shortness of breath swollen or painful glands swollen tongue thirst that continues tightness in the chest with or without wheezing unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds yellow eyes or skin Some side effects of ketorolac may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain (mild or moderate) bruising at place of injection diarrhea dizziness drowsiness headache indigestion nausea Less common or rare Bloating or gas burning or pain at place of injection constipation feeling of fullness in abdominal or stomach area increased sweating vomiting For Healthcare Professionals Applies to ketorolac: injectable solution, nasal spray, oral tablet General The most common adverse reactions among patients treated with ketorolac (the active ingredient contained in Sprix) include abdominal pain, nausea, dyspepsia, and headaches. For patients receiving the nasal spray, nasal discomfort, rhinalgia, increased lacrimation, throat irritation, and rhinitis were reported. [ Ref ] Gastrointestinal A large postmarketing observational study (n=10,000) revealed the incidence of clinically serious gastrointestinal (GI) bleeding was dose dependent and more than double in patients 65 years or older. The incidence of clinically serious GI bleeding after up to 5 days of treatment with doses of 60 mg or less, greater than 60 to 90 mg, greater than 90 to 120 mg, or greater than 120 mg, respectively was 0.4%, 0.4%, 0.9%, and 4.6% in those less than 65 years compared with 1.2%, 2.8%, 2.2%, and 7.7% in those 65 years or older. Among patients with a history of GI perforation, ulcer, or bleeding, these numbers were 2.1%, 4.6%, 7.8%, and 15.4% compared with 4.7%, 3.7%, 2.8%, and 25%, in younger and older patients, respectively. [ Ref ] Very common (10% or more): Abdominal pain, dyspepsia, nausea Common (1% to 10%): Constipation, diarrhea, flatulence, gastrointestinal (GI) fullness, GI ulcers (gastric/duodenal), gross bleeding/perforation, heartburn, stomatitis, vomiting, throat irritation (nasal spray) Frequency not reported: Anorexia, dry mouth, eructation, esophagitis, excessive thirst, gastritis, glossitis, hematemesis, melena, rectal bleeding, increased appetite, peptic ulcers, ulcers, hematemesis, gastritis Postmarketing reports: Acute pancreatitis, liver failure, ulcerative stomatitis, exacerbation of inflammatory bowel disease (ulcerative colitis, Crohn's disease), eructation [ Ref ] Hematologic Common (1% to 10%): Anemia, increased bleeding time Frequency not reported: Bleeding, hematoma, postoperative wound hemorrhage Postmarketing reports: Agranulocytosis, aplastic anemia, hemolytic anemia, lymphadenopathy, pancytopenia, thrombocytopenia purpura, thrombocytopenia, neutropenia, postoperative wound hemorrhage (rarely requiring blood transfusion) [ Ref ] Serious events of bleeding (n=4) or hematoma (n=3) at the operative site were reported in controlled clinical trials in patients (n=455) undergoing major surgeries (primarily knee and hip replacements, and abdominal hysterectomies) receiving ketorolac nasal spray compared with 1 patient in the placebo group (hematoma). In pediatric patients, an increased risk of bleeding was observed following tonsillectomy. In a retrospective analysis, risk of bleeding following a tonsillectomy with or without adenoidectomy was 10.1% in patients receiving this drug compared with 2.2% in those receiving opioids. The postoperative hemorrhage rate in patients 12 years and younger was 6.5% with ketorolac treatment versus 3.3% without. In a prospective study in patients 3 to 9 years undergoing tonsillectomy with or without adenoidectomy, the overall incidence of bleeding in patients receiving this drug was 16.3% compared with 17% in children receiving morphine. However, during the first 24 hours after surgery, bleeding was observed in 14.3% of the ketorolac group versus 4.2% of the morphine group. [ Ref ] Cardiovascular Common (1% to 10%): Edema, hypertension, bradycardia Frequency not reported: Congestive heart failure, palpitations, pallor, tachycardia, syncope, cardiac failure Postmarketing reports: Arrhythmia, chest pain, flushing, hypotension, myocardial infarction, vasculitis [ Ref ] Clinical trials of several cyclooxygenase (COX)-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. All NSAIDs appear to have a similar risk. There is no consistent evidence that concurrent use of aspirin mitigates this increased risk and may be associated with an increased risk of serious gastrointestinal events. [ Ref ] Dermatologic Common (1% to 10%): Rash, pruritus, purpura, sweating Very rare (less than 0.01%): Frequency not reported: Alopecia, photosensitivity, urticaria Postmarketing reports: Angioedema, exfoliative dermatitis, erythema multiforme, Lyell's syndrome, bullous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis [ Ref ] Hypersensitivity Frequency not reported: Anaphylactoid reactions Postmarketing reports: Laryngeal edema, tongue edema [ Ref ] Renal Common (1% to 10%): Abnormal renal function, oliguria Postmarketing reports: Acute renal failure, nephrotic syndrome [ Ref ] Hepatic Common (1% to 10%): Elevated liver enzymes Frequency not reported: Hepatitis, jaundice, liver failure [ Ref ] Metabolic Frequency not reported: Weight change Postmarketing reports: Hyperglycemia, hyperkalemia, hyponatremia [ Ref ] Respiratory Very common (10% or more): Nasal discomfort (15%, nasal spray), rhinalgia (13%, nasal spray) Common (1% to 10%): Rhinitis (nasal spray) Frequency not reported: Epistaxis, pulmonary edema, asthma Postmarketing reports: Bronchospasm, respiratory depression, pneumonia [ Ref ] Nervous system Very common (10% or more): Headaches Common (1% to 10%): Drowsiness, dizziness Frequency not reported: Extrapyramidal symptoms, hyperkinesis, inability to concentrate, insomnia, paresthesia, somnolence, stupor, tremors Postmarketing reports: Aseptic meningitis, convulsions, coma, taste abnormality [ Ref ] Local Common (1% to 10%): Injection site pain [ Ref ] Ocular Common (1% to 10%): Lacrimation increased (nasal spray) Postmarketing reports: Conjunctivitis, optic neuritis, visual disturbances, abnormal vision [ Ref ] Psychiatric Frequency not reported: Anxiety, depression, euphoria, hallucinations, abnormal dreams, abnormal thinking Postmarketing reports: Psychosis [ Ref ] Other Common (1% to 10%): Tinnitus Frequency not reported: Fever, asthenia, malaise, vertigo, hearing loss [ Ref ] Endocrine Frequency not reported: Female infertility [ Ref ] Genitourinary Postmarketing reports: Flank pain with or without hematuria and/or azotemia, hemolytic uremia syndrome, increased urinary frequency, oliguria, interstitial nephritis, urinary retention [ Ref ] Immunologic Frequency not reported: Infections, sepsis [ Ref ] Musculoskeletal Postmarketing reports: Myalgia [ Ref ] References 1. "Product Information. Toradol (ketorolac)." Roche Laboratories, Nutley, NJ. 2. Cerner Multum, Inc. "Australian Product Information." O 0 3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 4. "Product Information. Sprix (ketorolac)." American Regent Laboratories Inc, Shirley, NY. 5. "Product Information. Ketorolac Tromethamine (ketorolac)." Hospira Inc, Lake Forest, IL. Some side effects of Sprix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA . Next Dosage Print this page More about Sprix (ketorolac) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 12 Reviews Add your own review/rating Drug class: nonsteroidal anti-inflammatory agents Consumer resources Sprix Sprix nasal Sprix (Advanced Reading) Other brands: Toradol , Toradol IV/IM Professional resources Sprix Nasal Spray (FDA) Ketorolac Tromethamine (AHFS Monograph) Related treatment guides Pain Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Manufacturer Egalet Corporation Drug Class Nonsteroidal anti-inflammatory agents Related Drugs Pain tramadol , acetaminophen , Tylenol , naproxen , oxycodone , aspirin , ibuprofen , amitriptyline , hydrocodone , clonidine , Norco , diclofenac , Percocet , hydroxyzine , Voltaren , lidocaine topical , Aleve , Celebrex , morphine , acetaminophen / hydrocodone , fentanyl , diphenhydramine topical , Advil , More... Sprix Rating 12 User Reviews 8.2 /10 12 User Reviews 8.2 Rate it!} } it is important
TOP Products Sprix Side Effects be apologetic about
EmoticonEmoticon