service provider Clindamycin and Tretinoin Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Pronunciation (klin da MYE sin & TRET i noyn) Index Terms Clindamycin Phosphate and Tretinoin Clindamycin/Tretinoin Tretinoin and Clindamycin Veltin Slideshow Newborn Baby Health: 8 Woes From Cradle Cap And Colic To Whooping Cough Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Gel, topical: Veltin : Clindamycin phosphate 1.2% and tretinoin 0.025% (30 g, 60 g) Ziana : Clindamycin phosphate 1.2% and tretinoin 0.025% (30 g, 60 g) Generic: Clindamycin phosphate 1.2% and tretinoin 0.025% (30 g, 60 g) Brand Names: U.S. Veltin Ziana Pharmacologic Category Acne Products Retinoic Acid Derivative Topical Skin Product Topical Skin Product, Acne Pharmacology Clindamycin reversibly binds to 50S ribosomal subunits preventing peptide chain elongation thus inhibiting bacterial protein synthesis. Clindamycin exhibits in vitro activity against Cutibacterium acnes , an organism associated with acne vulgaris. Topical tretinoin is believed to decrease follicular epithelial cells cohesiveness and increase follicular epithelial cell turnover resulting in decreased microcomedo formation and increased expulsion of comedones. Absorption Topical: Tretinoin: Minimal systemic absorption; Clindamycin: Low, but variable systemic absorption Use: Labeled Indications Acne: For the treatment of acne vulgaris in patients 12 years. Contraindications Regional enteritis, ulcerative colitis, history of antibiotic-associated colitis Dosing: Adult Acne: Topical: Apply once daily in the evening or at bedtime Dosing: Pediatric Acne: Topical: Children 12 years and Adolescents: Refer to adult dosing. Dosing: Renal Impairment There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption. Dosing: Hepatic Impairment There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption. Administration For external use only. Not for ophthalmic, oral, or intravaginal use. Prior to application, gently wash face with a mild soap and pat dry. Apply in the evening or at bedtime. Apply a pea-size amount to one fingertip and then dotted on chin, cheeks, nose, and forehead. Avoid contact with sunburned skin. Gently rub over entire face or entire affected area while avoiding eyes, mouth, angles of nose, and mucous membranes. Storage Store at 25 C (77 F); excursions permitted to 15 C to 30 C (59 F to 86 F); do not freeze. Protect from heat and light. Drug Interactions Aminolevulinic Acid (Systemic): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Systemic). Avoid combination Aminolevulinic Acid (Topical): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Topical). Monitor therapy Erythromycin (Systemic): May diminish the therapeutic effect of Clindamycin (Topical). Avoid combination Erythromycin (Topical): May diminish the therapeutic effect of Clindamycin (Topical). Avoid combination Multivitamins/Fluoride (with ADE): May enhance the adverse/toxic effect of Retinoic Acid Derivatives. Avoid combination Multivitamins/Minerals (with ADEK, Folate, Iron): May enhance the adverse/toxic effect of Retinoic Acid Derivatives. Avoid combination Multivitamins/Minerals (with AE, No Iron): May enhance the adverse/toxic effect of Retinoic Acid Derivatives. Avoid combination Neuromuscular-Blocking Agents: Clindamycin (Topical) may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Monitor therapy Verteporfin: Photosensitizing Agents may enhance the photosensitizing effect of Verteporfin. Monitor therapy Adverse Reactions Frequency not defined. >10%: Dermatologic: Burning sensation of skin, desquamation, erythema, xeroderma 1% to 10%: Dermatologic: Dermatitis, pruritus, skin irritation, stinging of the skin, sunburn Gastrointestinal: Gastrointestinal symptoms (unspecified) Respiratory: Nasopharyngitis Warnings/Precautions Concerns related to adverse effects: Photosensitivity: Tretinoin use is associated with increased susceptibility/sensitivity to ultraviolet (UV) light; avoid sunlamps or excessive sunlight exposure. Daily sunscreen use and other protective measures recommended. Use is not recommended in patients with sunburn. Skin irritation: Treatment can increase skin sensitivity to weather extremes of wind or cold. Also, concomitant topical medications (eg, medicated or abrasive soaps, cleansers, or cosmetics with a strong drying effect) should be used with caution due to increased skin irritation. Superinfection: Prolonged use may result in fungal or bacterial superinfection, including Clostridium difficile associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment. Discontinue drug if significant diarrhea, abdominal cramps, or passage of blood and mucus occurs. Concurrent drug therapy issues: Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information. Dosage form specific issues: Polysorbate 80: Some dosage forms may contain polysorbate 80 (also known as Tweens). Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals (Isaksson, 2002; Lucente 2000; Shelley, 1995). Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 (Alade, 1986; CDC, 1984). See manufacturer s labeling. Other warnings/precautions: Appropriate use: For external use only; not for ophthalmic, oral, or intravaginal use; avoid mucous membranes, eyes, mouth, and angles of nose. Pregnancy Risk Factor C Pregnancy Considerations Adverse events were observed in animal reproduction studies using this combination topically. See individual agents. Patient Education Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?) Patient may experience skin irritation, itching, burning, peeling, or skin discoloration. Have patient report immediately to prescriber severe injection site irritation; severe diarrhea; black, tarry, or bloody stools; abdominal pain; or abdominal cramps (HCAHPS). Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients. Next Interactions Print this page Add to My Med List More about clindamycin/tretinoin topical Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 108 Reviews Add your own review/rating Drug class: topical acne agents Consumer resources Clindamycin and tretinoin topical Clindamycin and Tretinoin Clindamycin and tretinoin Topical application (Advanced Reading) Professional resources Clindamycin and Tretinoin Gel (FDA) Other brands: Veltin , Ziana Related treatment guides Acne} Antibiotics 101 Everything you need to know about antibiotics: List of Common Antibiotics & Types Antibiotics & Drinking Alcohol - Is it Safe? Antibiotics For UTI - What Are My Options? Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Clindamycin / tretinoin topical Rating 108 User Reviews 7.4 /10 108 User Reviews 7.4 Rate it! Manufacturer Teva Pharmaceuticals USA, Inc. Drug Class Topical acne agents Related Drugs topical acne agents clindamycin topical , erythromycin topical , tretinoin topical , tetracycline topical , dapsone topical , Finacea Acne doxycycline , clindamycin topical , erythromycin topical , minocycline , tretinoin topical , tetracycline topical , dapsone topical , Accutane , Vibramycin , Retin-A , isotretinoin , Minocin , Ortho Tri-Cyclen , Yasmin , Monodox , adapalene topical , Yaz , TriNessa , Epiduo , Claravis , Benzaclin , Tazorac , Differin , Adoxa , More...} } aggravating
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