the difficulty [1%:99%, primarily to albumin Use: Labeled Indications HIV-1 infection: Treatment of HIV-1 infection in combination with other antiretroviral agents in adults and pediatric patients at least 3 months old and weighing at least 3.5 kg Contraindications Hypersensitivity (eg, Stevens-Johnson syndrome, erythema multiforme, toxic skin eruptions) to efavirenz or any component of the formulation; concurrent administration with elbasvir or grazoprevir Canadian labeling: Additional contraindications (not in US labeling): Concurrent administration with cisapride (not available in Canada), ergot derivatives (eg, dihydroergotamine, ergonovine, ergotamine), midazolam, pimozide, St. John's wort, triazolam Dosing: Adult HIV-1 infection, treatment: Oral: 600 mg once daily. Dosage adjustment for concomitant rifampin (only if patient weighs 50 kg): Increase efavirenz dose to 800 mg once daily. Dosage adjustment for concomitant voriconazole: Reduce efavirenz dose to 300 mg once daily and increase voriconazole to 400 mg every 12 hours. Dosing: Geriatric Refer to adult dosing. Dosing: Pediatric HIV-1 infection, treatment: Manufacturer's labeling: Infants 3 months and 3.5 kg: Oral: Note: Although FDA approved in pediatric patients 3 months of age and weighing 3.5 kg, pharmacokinetic data suggest that the FDA-approved dosing may result in subtherapeutic levels in extensive metabolizers and supratherapeutic in slow metabolizers, and use should be avoided (HHS [pediatric] 2016). 3.5 kg to] Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Efavirenz Rating 7 User Reviews 6.6 /10 7 User Reviews 6.6 Rate it! Manufacturer Mylan Pharmaceuticals Inc. Drug Class NNRTIs Related Drugs NNRTIs Intelence , Sustiva , nevirapine , Edurant , etravirine , Viramune HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , More... Nonoccupational Exposure Truvada , Atripla , Viread , lamivudine , abacavir , tenofovir , Epzicom , Reyataz , More... Occupational Exposure Truvada , Atripla , Viread , Isentress , lamivudine , abacavir , tenofovir , Epzicom , More... unhurt
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