time for supper rosiglitazone (Oral route) roe-zi-GLI-ta-zone Oral route(Tablet) Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive heart failure in some patients. After initiation of rosiglitazone maleate, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop, the heart failure should be managed according to current standards of care. Furthermore, discontinuation or dose reduction of rosiglitazone maleate must be considered. Rosiglitazone maleate is not recommended in patients with symptomatic heart failure. Initiation of rosiglitazone maleate in patients with established NYHA Class III or IV heart failure is contraindicated . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Avandia Available Dosage Forms: Tablet Therapeutic Class: Antidiabetic Chemical Class: Thiazolidinedione Slideshow Metformin: 10 Things You Should Know Uses For rosiglitazone Rosiglitazone is used to treat a type of diabetes mellitus called type 2 diabetes. It may be used alone or with other medicines such as metformin or sulfonylurea agents. Rosiglitazone is used together with a proper diet and exercise to help control blood sugar levels. It does this by helping your body use insulin better. rosiglitazone is available only with your doctor's prescription. Before Using rosiglitazone In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rosiglitazone, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to rosiglitazone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of rosiglitazone in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rosiglitazone in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rosiglitazone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using rosiglitazone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Balofloxacin Besifloxacin Ceritinib Ciprofloxacin Enoxacin Entacapone Fleroxacin Flumequine Gatifloxacin Gemifloxacin Insulin Insulin Aspart, Recombinant Insulin Bovine Insulin Degludec Insulin Detemir Insulin Glargine, Recombinant Insulin Glulisine Insulin Lispro, Recombinant Lanreotide Levofloxacin Lomefloxacin Moxifloxacin Nadifloxacin Norfloxacin Octreotide Ofloxacin Pasireotide Pazufloxacin Pefloxacin Pixantrone Prulifloxacin Rufloxacin Sparfloxacin Thioctic Acid Tosufloxacin Using rosiglitazone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Atenolol Betaxolol Bisoprolol Bitter Melon Carteolol Carvedilol Celiprolol Esmolol Fenofibrate Fenofibric Acid Fenugreek Gemfibrozil Glucomannan Guar Gum Labetalol Levobunolol Metipranolol Metoprolol Nadolol Nebivolol Opicapone Oxprenolol Penbutolol Pindolol Practolol Propranolol Psyllium Rifampin Sotalol Timolol Trimethoprim Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of rosiglitazone. Make sure you tell your doctor if you have any other medical problems, especially: Angina, severe and acute or Diabetic ketoacidosis (ketones in the blood) or Heart attack, acute or Heart failure, severe or with symptoms or Type 1 diabetes Should not be used in patients with these conditions. Patient with kidney disease -- Should not use this drug in combination with metformin in patients with this condition. Diabetic macular edema (swelling of the back of the eye) or Edema (fluid retention or swelling) or Heart attack, history of or Heart disease, history of or Liver disease Use with caution. May make these conditions worse. Fever or Infection or Surgery or Trauma Use with caution. These conditions may cause problems with blood sugar control. Fragile bones (especially in women) Use with caution. rosiglitazone may increase the risk for fractures. Proper Use of rosiglitazone Take rosiglitazone only as directed by your doctor . Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. rosiglitazone should come with a Medication Guide. It is very important that you read and understand this information. Ask your doctor if you have any questions. rosiglitazone may be taken with or without food. Carefully follow the special diet your doctor gave you . This is the most important part of controlling your diabetes and will help the medicine work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Dosing The dose of rosiglitazone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rosiglitazone. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For type 2 diabetes: Adults At first, 4 milligrams (mg) per day, taken as a single dose or divided into two doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 8 mg per day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of rosiglitazone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using rosiglitazone It is very important that your doctor check your progress at regular visits to make sure that rosiglitazone is working properly. Blood and urine tests may be needed to check for unwanted effects. Call your doctor right away if you have chest pain or discomfort, nausea, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, sweating, or vomiting. These may be symptoms of a heart attack . If you are rapidly gaining weight or having shortness of breath, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor right away. These may be symptoms of a heart problem or edema (fluid retention). If you have abdominal or stomach pain, dark urine, a loss of appetite, nausea or vomiting, unusual tiredness or weakness, or yellow eyes or skin, check with your doctor right away. These may be symptoms of a serious liver problem. Check with your doctor right away if blurred vision, difficulty in reading, or any other change in vision occurs while you are taking rosiglitazone. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). rosiglitazone may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures. Certain women may be at an increased risk for pregnancy while taking rosiglitazone. If you had problems ovulating and had irregular periods in the past, rosiglitazone may cause you to ovulate. This could increase your chance of becoming pregnant. If you are a woman of childbearing potential, you should discuss birth control options with your doctor. Make sure any doctor or dentist who treats you knows that you are using rosiglitazone. rosiglitazone may affect the results of certain medical tests. It is very important to carefully follow any instructions from your doctor about: Alcohol Drinking alcohol may cause severe low blood sugar. Discuss this with your doctor. Other medicines Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, diabetic patients may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy. Travel Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times. In case of emergency There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines. Symptoms of fluid retention Know what to do if you start to retain fluid. Fluid retention may worsen or lead to heart problems. rosiglitazone does not cause hypoglycemia (low blood sugar). However, low blood sugar can occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, cannot eat because of nausea or vomiting, or take rosiglitazone with another type of diabetes medicine. The symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly . Symptoms of low blood sugar include anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache (continuing), nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness. If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes, or drink fruit juice, non-diet soft drinks, or sugar dissolved in water to relieve the symptoms. Also, check your blood for low blood sugar. Glucagon is used in emergency situations when severe symptoms such as seizures (convulsions) or unconsciousness occur. Have a glucagon kit available, along with a syringe and needle, and know how to use it. Members of your family also should know how to use it. Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. Symptoms of high blood sugar include blurred vision, drowsiness, dry mouth, flushed, dry skin, fruit-like breath odor, increased urination (frequency and amount), ketones in the urine, loss of appetite, sleepiness, stomachache, nausea, or vomiting, tiredness, troubled breathing (rapid and deep), unconsciousness, or unusual thirst. If the symptoms of high blood sugar occur, check your blood sugar level and call your doctor for instructions. rosiglitazone Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Abdominal or stomach pain blurred vision chest pain or discomfort decrease in the amount of urine dry mouth flushed, dry skin fruit-like breath odor increased hunger increased thirst increased urination irregular heartbeat nausea noisy, rattling breathing pain in the shoulders, arms, jaw, or neck pale skin rapid or unusual weight gain sweating swelling of the fingers, hands, feet, or lower legs trouble breathing unexplained weight loss unusual bleeding or bruising unusual tiredness or weakness vomiting Rare Anxiety chills cold sweats coma confusion dark urine depression dizziness fast heartbeat headache loss of appetite nightmares seizures shakiness slurred speech Incidence not known Blue lips and fingernails changes in vision coughing that sometimes produces a pink frothy sputum hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs itching or skin rash light-colored stools redness of the skin yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Ear congestion fever general feeling of discomfort or illness hoarseness or other voice changes injury joint pain muscle aches and pains runny or stuffy nose shivering sneezing sore throat trouble sleeping Less common Back pain cough diarrhea lightheadedness pain or tenderness around the eyes and cheekbones Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 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Next Side Effects Print this page Add to My Med List More about rosiglitazone Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 8 Reviews Add your own review/rating Drug class: thiazolidinediones Consumer resources Rosiglitazone Other brands: Avandia Professional resources Rosiglitazone Maleate (AHFS Monograph) Rosiglitazone (FDA) Rosiglitazone (Wolters Kluwer) Related treatment guides Diabetes, Type 2 Nonalcoholic Fatty Liver Disease} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Thiazolidinediones Related Drugs Diabetes, Type 2 metformin , insulin aspart , glipizide , glimepiride , Januvia , pioglitazone , Victoza , Actos , Tradjenta , Glucophage , glyburide , Janumet , Invokana , Amaryl , Welchol , Onglyza , sitagliptin , Trulicity , Jardiance , Lantus , Farxiga , Levemir , Tresiba , Glucotrol , Bydureon , More... Rosiglitazone Rating 8 User Reviews 5.4 /10 8 User Reviews 5.4 Rate it! Related Questions & Answers Metformin/Rosiglitazone - I am using Metformin with Insuling from last 1 year. I heard Metformin is? Why was rosiglitazone taken off the market (almost) but pioglitazone was not? What causes rosiglitazone to cause increase risk of having heart failures? Read more questions} } of ethical
refrained from rosiglitazone (Oral route) today
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