weak spot aprepitant (Oral route) ap-RE-pi-tant Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Emend Available Dosage Forms: Powder for Suspension Capsule Therapeutic Class: Antiemetic Pharmacologic Class: Neurokinin-1 Receptor Antagonist Slideshow Understanding Insulin: What You Need To Know Uses For aprepitant Aprepitant capsules and oral suspension are used in combination with other medicines to prevent the nausea and vomiting that may occur during cancer treatment (chemotherapy). Aprepitant capsules are also used to prevent nausea and vomiting that may occur after surgery. Aprepitant works in the nervous system to block the action of a chemical that causes vomiting. aprepitant is available only with your doctor's prescription. Before Using aprepitant In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aprepitant, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to aprepitant or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of aprepitant in the pediatric population. Safety and efficacy of aprepitant to prevent nausea and vomiting after surgery have not been established in children, and to prevent nausea and vomiting caused by cancer medicines in children younger than 6 months of age. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aprepitant in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aprepitant, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using aprepitant with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Flibanserin Lomitapide Pimozide Using aprepitant with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atazanavir Boceprevir Bosutinib Brexpiprazole Carbamazepine Ceritinib Cilostazol Clarithromycin Cobicistat Cobimetinib Colchicine Conivaptan Dasatinib Deflazacort Desogestrel Dienogest Diltiazem Docetaxel Domperidone Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Drospirenone Enzalutamide Eplerenone Erythromycin Estradiol Cypionate Estradiol Valerate Ethinyl Estradiol Ethynodiol Diacetate Etonogestrel Fluconazole Fosphenytoin Hydrocodone Ibrutinib Idelalisib Imatinib Indinavir Itraconazole Ivabradine Ivacaftor Ketoconazole Levonorgestrel Lopinavir Lumacaftor Lurasidone Medroxyprogesterone Acetate Mestranol Mitotane Naloxegol Nefazodone Nelfinavir Norelgestromin Norethindrone Norgestimate Norgestrel Olaparib Oxycodone Phenytoin Piperaquine Posaconazole Ranolazine Rifampin Ritonavir Saquinavir Simeprevir Sonidegib St John's Wort Tacrolimus Telaprevir Telithromycin Tolvaptan Venetoclax Verapamil Voriconazole Warfarin Using aprepitant with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Dexamethasone Methylprednisolone Midazolam Quetiapine Sirolimus Suvorexant Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using aprepitant with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aprepitant, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Proper Use of aprepitant Take aprepitant only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. aprepitant comes with patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Aprepitant is given together with other medicines to prevent vomiting from chemotherapy . Carefully follow your doctor's instructions about how to take the medicines. You may take aprepitant with or without food. Swallow the capsule whole. Do not crush, break, or chew it. To use the oral suspension : For each dose of aprepitant, you will receive a prefilled oral dosing dispenser that contains your prescribed dose. Call your doctor right away if you or your child is not able to take the prescribed dose. Throw away the oral dosing dispenser and cap after each use. Do not start taking aprepitant if you already have nausea and vomiting. Contact your doctor about what to do. Dosing The dose of aprepitant will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of aprepitant. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (capsules): For prevention of nausea and vomiting caused by chemotherapy: Adults and children 12 years of age and older 125 milligrams (mg) 1 hour before chemotherapy (Day 1). Then, 80 mg once in the morning on Days 2 and 3. Children younger than 12 years of age, weighing at least 30 kilograms (kg), and can swallow a capsule 125 mg 1 hour before chemotherapy (Day 1). Then, 80 mg once in the morning on Days 2 and 3. Children younger than 12 years of age weighing less than 30 kg Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults 40 milligrams (mg) within 3 hours before surgery. Children Use and dose must be determined by your doctor. For oral dosage form (powder for suspension): For prevention of nausea and vomiting caused by chemotherapy: Adults and children 6 months to 11 years of age and cannot swallow the capsule Dose is based on body weight and must be determined by your doctor. The dose is usually 3 milligrams (mg) per kilogram (kg) of body weight up to a maximum dose of 125 mg taken 1 hour before chemotherapy (Day 1). Then, 2 mg per kg of body weight up to a maximum dose of 80 mg taken once in the morning on Days 2 and 3. Children younger than 6 months of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of aprepitant, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep the oral liquid in the oral dosing dispenser in the refrigerator for up to 72 hours before use. You may also keep the medicine at room temperature for up to 3 hours. Precautions While Using aprepitant It is very important that your doctor check your progress while you are using aprepitant to make sure it is working properly and to check for unwanted effects. Do not use aprepitant if you are also using pimozide (Orap ). Using these medicines together may cause serious unwanted side effects . aprepitant may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have itching, hives, rash, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using aprepitant. Birth control pills may not work as well while you are using aprepitant. To keep from getting pregnant, use another form of birth control together with your pills while you are using the medicine and for 1 month after your last dose. Other forms of birth control include condoms, diaphragms, or contraceptive foams or jellies. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. aprepitant Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Black or tarry stools chills cough fever lower back or side pain painful or difficult urination pale skin shortness of breath sore throat ulcers, sores, or white spots in the mouth unusual bleeding or bruising unusual tiredness or weakness Incidence not known Blistering, peeling, or loosening of the skin confusion about identity, place, and time diarrhea itching or skin rash joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs redness of the skin red, irritated eyes red skin lesions, often with a purple center slow or irregular heartbeat Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach belching confusion decreased urination dizziness dry mouth fainting heartburn hiccups increase in heart rate indigestion lack or loss of strength lightheadedness loss of appetite nausea rapid breathing stomach discomfort upset or pain sunken eyes swelling or inflammation of the mouth thirst weight loss wrinkled skin Less common Burning feeling in the chest or stomach hot flashes indigestion pain or discomfort in the chest, upper stomach, or throat tenderness in the stomach area Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about aprepitant Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 12 Reviews Add your own review/rating Drug class: NK1 receptor antagonists Consumer resources Aprepitant Aprepitant Capsules Aprepitant Oral Suspension Other brands: Emend Professional resources Aprepitant/Fosaprepitant Dimeglumine (AHFS Monograph) Aprepitant (FDA) Aprepitant (Wolters Kluwer) Related treatment guides Nausea/Vomiting, Postoperative Nausea/Vomiting, Chemotherapy Induced} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Sandoz Inc. Glenmark Pharmaceuticals Inc., USA Drug Class NK1 receptor antagonists Related Drugs Nausea / Vomiting, Chemotherapy Induced lorazepam , ondansetron , Zofran , Ativan , dexamethasone , metoclopramide , Reglan , Decadron , Marinol , dronabinol , More... Nausea / Vomiting, Postoperative ondansetron , Zofran , metoclopramide , Reglan , Zofran ODT , Emend , Aloxi , granisetron , palonosetron , droperidol , Kytril , More... Aprepitant Rating 12 User Reviews 9.9 /10 12 User Reviews 9.9 Rate it! Aprepitant Images Aprepitant systemic 40 mg (G 583) View all images Help and Support Looking for answers? Ask a question or go join the aprepitant support group to connect with others who have similar interests.} } everybody
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