presupposed to 40% (31/77) had HBV DNA> <300 copies/mL at end of dosing (up to 96 weeks). Lamivudine-refractory subjects (n=157) who failed to achieve the study-defined complete response by Week 96 were offered continued Entecavir treatment. Subjects received 1 mg Entecavir once daily for up to an additional 144 weeks. Of these subjects prone to
be at liberty the median fold-change in Entecavir EC 50 values from reference was 19-fold at baseline and 106-fold at the time of virologic rebound. For subjects who continued treatment beyond 48 weeks annoying
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