inactiveness corticotropin (Injection route) kor-ti-koe-TROE-pin ree-POZ-i-tor-ee Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. H.P. Acthar In Canada Acthar Available Dosage Forms: Gel/Jelly Therapeutic Class: Diagnostic Agent, Adrenocortical Function Pharmacologic Class: Corticotropin Slideshow A Joint Effort: A Provider's Guide To Orthopedic Pain Options Uses For corticotropin Repository corticotropin injection is used to treat infantile spasms (seizures) in babies and children younger than 2 years of age. It is also used to treat multiple sclerosis in adults. corticotropin is also used to treat joint disorders (e.g., psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis); autoimmune diseases (e.g., systemic lupus erythematosus or SLE, polymyositis); and certain conditions of the skin (e.g., erythema multiforme, Stevens-Johnson syndrome), eyes (e.g., keratitis, optic neuritis), and lungs (e.g., sarcoidosis). It is also used to treat certain allergies (e.g., serum sickness) and swelling (edema) of the body. corticotropin is available only with your doctor's prescription. Before Using corticotropin In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For corticotropin, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to corticotropin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of repository corticotropin injection to treat infantile spasms in babies and children younger than 2 years of age. Geriatric No information is available on the relationship of age to the effects of repository corticotropin injection in geriatric patients. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking corticotropin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using corticotropin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Rotavirus Vaccine, Live Using corticotropin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Bupropion Using corticotropin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Licorice Saiboku-To Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of corticotropin. Make sure you tell your doctor if you have any other medical problems, especially: Adrenal problems or Allergy to pork proteins, history of or Congenital (inborn) infections or Congestive heart failure or Fungus infections, systemic or Herpes simplex of the eye or Hypertension (high blood pressure), uncontrolled or Osteoporosis (thinning of the bones) or Peptic ulcer, or history of or Scleroderma (autoimmune disease) or Surgery, recent Should not be used in patients with these conditions. Cataracts or Cirrhosis (liver problem) or Cushing's syndrome (adrenal gland disorder) or Depression, history of or Diabetes or Edema (fluid retention or swelling) or Emotional problems or Eye infections (fungus, virus) or Glaucoma or Hypertension (high blood pressure), controlled or Hypokalemia (low potassium in the blood) or Hypothyroidism (underactive thyroid) or Kidney disease, severe or Mental illness (e.g., psychosis) or Myasthenia gravis (severe muscle weakness) or Stomach problems (ulcer, bleeding, or perforation) or Tuberculosis, latent Use with caution. May make these conditions worse. Infection (bacteria, virus, parasite, or protozoa) May decrease your body's ability to fight infection. Lennox-Gastaut syndrome May cause this condition to occur while using corticotropin to treat infantile spasms. Proper Use of corticotropin A nurse or other trained health professional will give you or your child corticotropin. corticotropin is given as a shot under your skin or into one of your muscles. Repository corticotropin injection may sometimes be given at home to patients who do not need to be in the hospital. If you are using corticotropin at home, your or your child's doctor will teach you how to prepare and inject the medicine. Be sure that you understand exactly how the medicine is prepared and injected . If your child is receiving repository corticotropin injection to treat infantile spasms , corticotropin usually comes with a Medication Guide. It is very important that you read and follow the instructions carefully. Be sure to ask your child's doctor about anything you do not understand. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot . Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. To use: Take the vial from the refrigerator and let it warm to room temperature before using it. Do not over-pressurize the vial before withdrawing the medicine. Wash your hands before and after using corticotropin. Wipe the injection site with a new sterile alcohol wipe and let it dry before giving an injection. Clean the top of the rubber stopper vial with a new sterile alcohol wipe. Use a new needle or syringe to get the prescribed amount of medicine to be injected. Give the medicine the way your doctor has instructed you. Return the vial to the refrigerator after using it. Dosing The dose of corticotropin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of corticotropin. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For injection dosage form (gel): For infantile spasms: Children 2 years of age and older Use and dose must be determined by your doctor. Infants and children younger than 2 years of age Dose is based on body size and must be determined by your child's doctor. The dose is 150 units per square meter (U/m2) of body size divided into two equal doses injected into a muscle per day for 2 weeks. Your child's doctor will adjust the dose as needed. For multiple sclerosis: Adults The dose is usually 80 to 120 units injected under your skin or into a muscle per day for 2 to 3 weeks. Your doctor will adjust your dose as needed. Children Use and dose must be determined by your doctor. For other indications (joint disorders, autoimmune diseases, allergies, swelling, and certain conditions of the skin, eyes, and lungs): Adults The dose is usually 40 to 80 units injected under your skin or into a muscle every 24 to 72 hours. Your doctor will adjust your dose as needed. Children Use and dose must be determined by your doctor. Missed Dose corticotropin needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions. Storage Store in the refrigerator. Do not freeze. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets. Precautions While Using corticotropin It is very important that your doctor check the progress of you or your child at regular visits to make sure that corticotropin is working properly. Blood tests may be needed to check for any unwanted effects. Do not receive live vaccines while you or your child are using corticotropin. Using corticotropin while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. corticotropin may increase your risk of developing infections. Avoid being near people who are sick or have infections while you are using corticotropin. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Using too much of corticotropin or using it for a long time may increase your risk of having adrenal gland problems (e.g., Cushing's syndrome). The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using corticotropin: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; fractures; increased thirst or urination; irritability; round or "moon" face, neck, or trunk; stomach pain; thin skin or easy bruising; weight gain or loss; or unusual tiredness or weakness. corticotropin may cause fluid retention (edema) in some patients. Carefully follow your doctor's instructions about any special diet (especially on salt intake). corticotropin may mask or hide symptoms of other diseases while you are using it. Check with your doctor if you or your child have symptoms of infection; black, tarry stools; changes in body weight; difficulty with breathing; fast heart rate; increased thirst; stomach pain; unusual tiredness; or vomiting. Check with your doctor right away if you start having severe abdominal or stomach burning, cramps, or pains; bloody or black, tarry stools; constipation or diarrhea; heartburn; indigestion; nausea; or vomiting of material that looks like coffee grounds. These could be symptoms of a serious stomach or bowel problem. corticotropin may cause changes in mood and behavior. Check with your doctor if you or your child have trouble sleeping, feeling depressed or irritable, mood swings, or other changes in behavior. Check with your doctor right away if you or your child have any changes to your eyes, such as redness, itching, swelling, or vision changes while you are using corticotropin. Your doctor may want you to have your eyes checked by an eye doctor. corticotropin may decrease bone mineral density when used for a long time. A low bone mineral density can cause slow growth and may lead to osteoporosis at any age. If you have any questions about this ask your doctor. Do not stop using corticotropin suddenly without checking first with your doctor . Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely. corticotropin Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Backache blurred vision body aches or pain chest pain cough difficulty with breathing dizziness ear congestion earache facial hair growth in females fever or chills fractures full or round face, neck, or trunk headache increased thirst or urination irritability loss of sexual desire or ability loss of voice menstrual irregularities muscle wasting nasal congestion nervousness pounding in the ears redness or swelling in the ear runny nose shortness of breath slow or fast heartbeat sneezing sore throat tightness in the chest troubled breathing unusual tiredness or weakness wheezing white patches in the mouth or throat or on the tongue white patches with diaper rash Less common Convulsions (seizures) Incidence not known Accumulation of pus bruising bulging soft spot on the head of an infant change in the ability to see colors, especially blue or yellow cold, clammy skin confusion decreased range of motion decreased urine output dilated neck veins extreme fatigue eyeballs bulge out of eye sockets fast, weak pulse full or bloated feeling heartburn insomnia irregular breathing irregular heartbeat joint pain large, flat, blue, or purplish patches in the skin lightheadedness limp loss of appetite nausea and vomiting pressure in the stomach severe headache small red or purple spots on the skin sweating swelling of abdominal or stomach area swelling of the face, fingers, feet, or lower legs swollen, red, or tender area of infection trouble healing weight gain wheezing Incidence not known-For adults only Bloating chills confusion constipation coughing up blood darkened urine fast heartbeat fever headache headache, sudden and severe increased sweating indigestion loss of appetite pain in the muscles pains in the stomach, side, or abdomen, possibly radiating to the back redness of the face skin rash unusual weight loss weakness yellow eyes or skin Incidence not known-For infants only Decreased carbohydrate tolerance hypokalemic alkalosis reversible brain shrinkage Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Blemishes on the skin diarrhea pimples Less common Increased or decreased appetite Incidence not known Increased hair growth, especially on the face menstrual changes muscle weakness Incidence not known-For adults only Feeling of constant movement of self or surroundings sensation of spinning thinning of the skin Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 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Acthar Gel Professional resources Corticotropin (AHFS Monograph) Corticotropin (Wolters Kluwer) Related treatment guides Allergies Ankylosing Spondylitis Chorioditis Chorioretinitis ... +21 more} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Corticotropin Related Drugs Ankylosing Spondylitis prednisone , naproxen , Humira , aspirin , triamcinolone , diclofenac , More... Sarcoidosis prednisone , triamcinolone , dexamethasone , azathioprine , Decadron , Imuran , More... Allergies hydroxyzine , levocetirizine , Vistaril , Xyzal , Atarax , doxylamine , More... Juvenile Rheumatoid Arthritis prednisone , naproxen , aspirin , ibuprofen , meloxicam , Aleve , More... 20 more conditions... Corticotropin Rating 14 User Reviews 7.5 /10 14 User Reviews 7.5 Rate it! Related Questions & Answers Corticotropin - RE: Injection site? Read more questions} } massive
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