habit defibrotide Generic Name: defibrotide (de FYE broe tide) Brand Name: Defitelio Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A What is defibrotide? Defibrotide works by increasing the breakdown of clots in the blood. Defibrotide is used to treat severe veno-occlusive disease (VOD) in adults and children who have undergone chemotherapy and a stem-cell transplant. VOD happens when blood vessels in the liver become blocked, which decreases blood flow and can lead to liver damage. Defibrotide may also be used for purposes not listed in this medication guide. Slideshow Inherited Risk: The BRCA Gene Explained What is the most important information I should know about defibrotide? Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. What should I discuss with my healthcare provider before receiving defibrotide? You should not use defibrotide if you are allergic to it, or if: you have active bleeding; you also take a blood thinner such as warfarin (Coumadin, Jantoven); or you use any medication to treat or dissolve blood clots such as streptokinase or urokinase. To make sure defibrotide is safe for you, tell your doctor if you have: a bleeding or blood clotting disorder. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether defibrotide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. How is defibrotide given? Defibrotide is injected into a vein through an IV. This medicine must be given slowly, and the IV infusion can last at least 2 hours. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used. Defibrotide is usually given for at least 21 days, to a maximum of 60 days if symptoms have not fully improved. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Defibrotide must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine. Do not mix defibrotide with other medicines in the same IV line. Follow your doctor's instructions about flushing your IV line after each injection. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine. After mixing defibrotide with a diluent, store in the refrigerator and use within 24 hours. Mixed medicine must be used within 4 hours if you keep it at room temperature. Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose. What happens if I miss a dose? Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while receiving defibrotide? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Defibrotide side effects Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin rash; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: easy bruising, unusual bleeding; blood in your urine or stools; confusion, headaches; vision problems, slurred speech; or a light-headed feeling, like you might pass out. Your treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: nausea, vomiting, diarrhea; dizziness; or nosebleeds. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Defibrotide dosing information Usual Adult Dose for Hepatic Veno-Occlusive Disease: 6.25 mg/kg IV every 6 hours given as a constant 2-hour infusion Duration of therapy: Minimum of 21 days; if signs and symptoms of hepatic veno-occlusive disease (VOD) remain after 21 days, continue this drug until resolution of VOD or up to a maximum of 60 days. Comments: Baseline body weight prior to the preparative regimen for hematopoietic stem-cell transplantation (HSCT) should be used to calculate the dose. Use: Treatment of patients with hepatic VOD, also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following HSCT. Usual Pediatric Dose for Hepatic Veno-Occlusive Disease: 1 Month or Older: 6.25 mg/kg IV every 6 hours given as a constant 2-hour infusion Duration of therapy: Minimum of 21 days; if signs and symptoms of hepatic veno-occlusive disease (VOD) remain after 21 days, continue this drug until resolution of VOD or up to a maximum of 60 days. Comments: Baseline body weight prior to the preparative regimen for hematopoietic stem-cell transplantation (HSCT) should be used to calculate the dose. Use: Treatment of patients with hepatic VOD, also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following HSCT. What other drugs will affect defibrotide? Other drugs may interact with defibrotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about defibrotide Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: miscellaneous coagulation modifiers Consumer resources Defibrotide Defibrotide Intravenous (Advanced Reading) Other brands: Defitelio Professional resources Defibrotide Sodium (AHFS Monograph) Related treatment guides Hepatic Veno-Occlusive Disease Where can I get more information? Your pharmacist can provide more information about defibrotide. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01. Date modified: December 03, 2017 Last reviewed: July 14, 2016} Drug Status Rx Availability Prescription only N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Miscellaneous coagulation modifiers Related Drugs Hepatic Veno-Occlusive Disease Defitelio , More... 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