is incredibly defibrotide (Intravenous route) dee-FYE-broe-tide Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Defitelio Available Dosage Forms: Solution Slideshow Men's Health Month And Movember: Raising The Profile Of Men's Health One Stache At A Time Uses For defibrotide Defibrotide injection is used to treat hepatic veno-occlusive disease in adults and children with kidney or lung problems who received hematopoietic stem-cell transplantation (HSCT). defibrotide is to be given by or under the supervision of your doctor. Before Using defibrotide In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For defibrotide, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to defibrotide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of defibrotide injection in children. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of defibrotide injection in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving defibrotide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using defibrotide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Abciximab Acenocoumarol Alteplase, Recombinant Anagrelide Anistreplase Apixaban Ardeparin Argatroban Aspirin Bemiparin Bivalirudin Certoparin Cilostazol Clopidogrel Dabigatran Etexilate Dalteparin Danaparoid Desirudin Dipyridamole Edoxaban Enoxaparin Eptifibatide Fondaparinux Heparin Iloprost Lepirudin Nadroparin Parnaparin Phenindione Phenprocoumon Prasugrel Protein C Reteplase, Recombinant Reviparin Rivaroxaban Streptokinase Sulfinpyrazone Tenecteplase Ticagrelor Ticlopidine Tinzaparin Tirofiban Treprostinil Urokinase Vorapaxar Warfarin Using defibrotide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Chamomile Citalopram Desvenlafaxine Escitalopram Fluoxetine Fluvoxamine Garlic Ginkgo Milnacipran Papaya Paroxetine Sertraline St John's Wort Tan-Shen Venlafaxine Using defibrotide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Chondroitin Coenzyme Q10 Curcumin Dong Quai Ginger Vitamin A Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using defibrotide with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use defibrotide, or give you special instructions about the use of food, alcohol, or tobacco. Avocado Other Medical Problems The presence of other medical problems may affect the use of defibrotide. Make sure you tell your doctor if you have any other medical problems, especially: Active bleeding Should not be given in patients with this condition. Bleeding problems Use with caution. May make these conditions worse. Proper Use of defibrotide A nurse or other trained health professional will give you or your child defibrotide in a hospital. defibrotide is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 2 hours. Precautions While Using defibrotide Your doctor will check your or your child's progress closely while you are receiving defibrotide . This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it and to check for unwanted effects. Do not use defibrotide if you are also using alteplase (Activase ) or heparin. defibrotide may increase your risk of bleeding. Tell your doctor if you or your child has the following symptoms: blood in the urine or stool, changes in vision, confusion, headache, slurred speech, unusual bleeding or bruising. defibrotide may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving defibrotide. defibrotide Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Black, tarry stools bloody nose bloody stools blurred vision chills confusion dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position fainting fast heartbeat fever lightheadedness rapid, shallow breathing sweating unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds Less common Chest pain cough or hoarseness lower back or side pain painful or difficult urination sneezing sore throat tightness in the chest troubled breathing Less common or rare Difficulty with swallowing hives, itching, or skin rash large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Incidence not known Bleeding gums coughing up blood headache increased menstrual flow or vaginal bleeding nosebleeds paralysis prolonged bleeding from cuts red or black, tarry stools red or dark brown urine Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea nausea vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about defibrotide Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: miscellaneous coagulation modifiers Consumer resources Defibrotide Other brands: Defitelio Professional resources Defibrotide Sodium (AHFS Monograph) Related treatment guides Hepatic Veno-Occlusive Disease} Drug Status Rx Availability Prescription only N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Miscellaneous coagulation modifiers Related Drugs Hepatic Veno-Occlusive Disease defibrotide , Defitelio , More... Defibrotide Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! 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