without end deferasirox (Oral route) dee-FER-a-sir-ox Oral route(Tablet;Tablet for Suspension;Granule) Acute renal failure, including death, may occur, especially in patients with comorbidities and advanced hematologic disorders. Close monitoring of renal function prior to initiation and during treatment is recommended. Reduce the dose, interrupt, or discontinue therapy if necessary, based on serum creatinine increases during treatment. Hepatic failure, including death, may also occur. Careful monitoring of serum transaminases and bilirubin prior to and during treatment is recommended. In patients with severe hepatic impairment, avoid use. Gastrointestinal (GI) hemorrhage, sometimes fatal, may also occur, especially in elderly patients with advanced hematologic malignancies or low platelet counts . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Exjade Jadenu Jadenu Sprinkle Available Dosage Forms: Tablet for Suspension Tablet Granule Therapeutic Class: Heavy Metal Chelator Slideshow Diabetic Nerve Pain: Symptoms And Treatment Uses For deferasirox Deferasirox is used to remove excess iron from the body in patients who had too many blood transfusions and in patients with non-transfusion dependent thalassemia syndromes. Deferasirox combines with iron in the blood. The combination of iron and deferasirox is then removed from the body by the kidneys. If you have too much iron in the body, it can damage various organs and tissues. deferasirox is available only with your doctor's prescription. Before Using deferasirox In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For deferasirox, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to deferasirox or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of deferasirox in children. Safety and efficacy have not been established in children with transfusional iron overload who are younger than 2 years of age, or in children with chronic iron overload and non-transfusional-dependent thalassemia who are younger than 10 years of age. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of deferasirox in the elderly. However, elderly patients are more likely to have unwanted effects and age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving deferasirox. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking deferasirox, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using deferasirox with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aluminum Carbonate, Basic Aluminum Hydroxide Aluminum Oxide Aluminum Phosphate Cholestyramine Colesevelam Colestipol Dihydroxyaluminum Aminoacetate Dihydroxyaluminum Sodium Carbonate Duloxetine Enzalutamide Fosphenytoin Phenobarbital Phenytoin Rifampin Ritonavir Theophylline Tizanidine Warfarin Using deferasirox with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Repaglinide Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other Medical Problems The presence of other medical problems may affect the use of deferasirox. Make sure you tell your doctor if you have any other medical problems, especially: Blood or bone marrow disorders (eg, agranulocytosis, anemia, neutropenia) or Eye problems (eg, cataracts, glaucoma) or Hearing problems or Kidney disease (eg, Fanconi's syndrome) or Stomach problems (eg, ulcers or bleeding, perforation) Use with caution. May make these conditions worse. Bone marrow problems (eg, myelodysplastic syndrome) or Cancer, advanced or Kidney disease, severe or Liver disease, severe or Thrombocytopenia (low platelet count in the blood) Should not be used in patients with these conditions. Liver disease (eg, hepatitis) You may need a lower dose of deferasirox. Proper Use of deferasirox Take deferasirox only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Swallow the tablet whole with water or other liquids. If you have trouble swallowing the whole tablet , it may be crushed and mixed with soft foods (eg, apple sauce or yogurt) immediately before taking it orally. Sprinkle the granules on soft food (eg, applesauce or yogurt) immediately before taking it orally. It is best to take the tablet and granules at the same time each day on an empty stomach or with a light meal. It is best to take tablet for suspension at the same time each day on an empty stomach, at least 30 minutes before you eat. Dissolve the tablet for suspension in water, orange juice, or apple juice. Mix well, then drink the mixture right away. To make sure you get all of the medicine, add some more liquid to the drinking glass, then drink all of this liquid too. Do not chew or swallow the tablet whole, and do not use it without mixing it in a liquid first . Dosing The dose of deferasirox will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of deferasirox. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For chronic iron overload after blood transfusions: For oral dosage form (granules): Adults and children 2 years of age and older Dose is based on body weight and must be determined by your doctor. The starting dose is usually 14 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 28 mg per kg per day. Children younger than 2 years of age Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and children 2 years of age and older Dose is based on body weight and must be determined by your doctor. The starting dose is usually 14 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 28 mg per kg per day. Children younger than 2 years of age Use and dose must be determined by your doctor. For oral dosage form (tablet for suspension): Adults and children 2 years of age and older Dose is based on body weight and must be determined by your doctor. The starting dose is usually 20 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg per kg per day. Children younger than 2 years of age Use and dose must be determined by your doctor. For chronic iron overload in non-transfusion dependent thalassemia syndrome: For oral dosage form (granules): Adults and children 10 years of age and older Dose is based on body weight and must be determined by your doctor. The starting dose is usually 7 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 14 mg per kg per day. Children younger than 10 years of age Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and children 10 years of age and older Dose is based on body weight and must be determined by your doctor. The starting dose is usually 7 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 14 mg per kg per day. Children younger than 10 years of age Use and dose must be determined by your doctor. For oral dosage form (tablet for suspension): Adults and children 10 years of age and older Dose is based on body weight and must be determined by your doctor. The starting dose is usually 10 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per kg per day. Children younger than 10 years of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of deferasirox, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using deferasirox It is very important that your doctor check your progress at regular visits to make sure that deferasirox is working properly. Blood and urine tests may be needed to check for unwanted effects. Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These may be symptoms of a serious kidney problem. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. Check with your doctor right away if you have abdominal or stomach pain, cramping, or burning, black, tarry stools, constipation, diarrhea, heartburn, indigestion, nausea, or vomiting of blood or material that looks like coffee grounds. These may be symptoms of a serious stomach or bowel problem. Deferasirox will lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. deferasirox may cause serious allergic reactions, including anaphylaxis and angioedema. These can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using deferasirox. Serious skin reactions can occur with deferasirox. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using deferasirox. Deferasirox may cause some people to have hearing and vision problems within a few weeks after they start taking it. If you notice any problems with your hearing or vision, such as blurred vision, difficulty with night vision, or difficulty with seeing colors, check with your doctor right away. If you have diarrhea or vomiting, drink plenty of water or fluids to keep your body hydrated. deferasirox may cause some people to become dizzy. Do not drive, use machines, or do anything else that could be dangerous until you know how deferasirox affects you . Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Do not take deferasirox with aluminum-containing antacids (Maalox , Mylanta ). deferasirox Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Diarrhea dizziness earache or pain in the ear nausea stomach pain voice changes vomiting Rare Blindness blurred vision change in hearing change in vision pain or discomfort in the eye Incidence not known Black, tarry stools bleeding gums blood in the urine or stools dark-colored urine decrease in the amount of urine general feeling of tiredness or weakness hives, welts, skin rash large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools lower back or side pain pale skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue redness, soreness, itching of the skin sores, blisters stomach pain, continuing unusual bleeding or bruising unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness vomiting of blood or material that looks like coffee grounds yellow eyes or skin Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about deferasirox Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: chelating agents Consumer resources Deferasirox Deferasirox Tablets Deferasirox Tablets For Oral Suspension Deferasirox Sprinkle Granules Other brands: Jadenu , Exjade , Jadenu Sprinkle Professional resources Deferasirox (AHFS Monograph) Deferasirox (Wolters Kluwer) Related treatment guides Iron Overload Hemosiderosis Thalassemia} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Chelating agents Related Drugs Iron Overload Jadenu , Exjade , Ferriprox , deferiprone , More... Thalassemia Jadenu , Exjade , Ferriprox , deferiprone , More... Hemosiderosis Exjade , More... Deferasirox Rating No Reviews - Be the first! 5.0 /10 No Reviews - Be the first! 5.0 Rate it! Related Questions & Answers Deferasirox - is there any combination therapy with deferasifox available? Deferasirox - Can Exjade be mixed with pineapple juice? Read more questions} } every now and then
delight deferasirox (Oral route) maybe
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