you are going to adore Is Mucinex (guaifenesin) safe during pregnancy? Mucinex (generic name guaifenesin) is an oral cough, cold, sinus and allergy medication, expectorant and decongestant usually considered safe in the second and third trimesters. However, the over-the-counter drug should be avoided in the first trimester due to potential risks to the growing fetus [1] . It is never recommended to take Mucinex in pregnancy without consulting your doctor regarding the potential risks and complications. Mucinex FDA Pregnancy Category Category C As animal studies have shown the drug to cross placenta and have certain adverse effects on the fetus. However, there is a lack of evidence in human studies [2] . Multi-symptom remedies and combination products such as Mucinex D and Mucinex DM contain other drugs such as pseudoephedrine and dextromethorphan along with guaifenesin as active ingredients. These are also assigned to Pregnancy Category C as risks of complications cannot be ruled out [3, 4] . How much Mucinex (guaifenesin) is safe in pregnancy? Normal dosages may not be recommended for expecting mothers. Make sure to follow the dosage directions of your physician to avoid any adverse outcome. What are the risks of taking Mucinex while pregnant? Guaifenesin in the first trimester: A study carried out by The Collaborative Perinatal Project with 197 pregnant women who took the drug in the first trimester showed no significant increase in the risk of birth defects, with 14 babies born having congenital malformations. Risk of neural tube defects: Certain case control studies have shown a possible association between the use of this drug and increased chances of having a baby with neural tube defects or inguinal hernias [5] . Risk of other birth defects: In another study done with 229,101 subjects, 141 women took oral guaifenesin in the first trimester while 349 took it later in their pregnancies. Nine birth defects, including 2 cases of cardiovascular defects were reported among the babies exposed to the drug in the first trimester. Mucinex while breastfeeding There is limited data regarding whether the medication enters breast milk when used by nursing mothers. Occasional small dosages are believed to cause no serious effects on infants, especially those aged over 2 months. It is advisable to evaluate the potential benefits and risks before using guaifenesin while breastfeeding . However, experts recommend avoiding guaifenesin products with high alcohol content, such as certain cough syrups [6, 7] . [ref] http://www.medscape.com/viewarticle/813743_3 http://reference.medscape.com/drug/mucinex-organidin-nr-guaifenesin-343403 http://www.drugs.com/mucinex-d.html http://www.drugs.com/mtm/mucinex-dm.html https://mospace.umsystem.edu/xmlui/handle/10355/3626 http://www.drugs.com/breastfeeding/guaifenesin.html http://www.mayoclinic.org/drugs-supplements/guaifenesin-oral-route/before-using/drg-20068720 [/ref] 140th
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