superb dinoprostone (Vaginal route) dye-noe-PROST-one Vaginal route(Suppository) Dinoprostone should be used with strict adherence to recommended dosages and only by medically trained personnel in a hospital setting that can provide immediate intensive care and acute surgical facilities . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Cervidil Prepidil Prostin E2 Available Dosage Forms: Tampon Suppository Gel/Jelly Insert, Extended Release Therapeutic Class: Uterine Stimulant Pharmacologic Class: Prostaglandin Slideshow Understanding Insulin: What You Need To Know Uses For dinoprostone Dinoprostone works by causing the cervix to thin and dilate (open) and the uterus to contract (cramp) the way it does during labor. Dinoprostone may also be used for other purposes as determined by your doctor. Dinoprostone is to be administered only by or under the immediate care of your doctor. Before Using dinoprostone In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dinoprostone, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to dinoprostone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of dinoprostone. Make sure you tell your doctor if you have any other medical problems, especially: Anemia (or history of) Dinoprostone, when used in doses that stimulate the uterus to contract, may result in loss of blood in some patients that may require a blood transfusion Asthma (or history of, including childhood asthma) or Lung disease Dinoprostone may cause narrowing of the blood vessels in the lungs or narrowing of the lung passages, especially when it is used in doses that stimulate the uterus to contract Epilepsy (or history of) Rarely, seizures have occurred with dinoprostone when it is used in doses that stimulate the uterus to contract Glaucoma Rarely, the pressure within the eye has increased and constriction of the pupils has occurred during the use of medicines like dinoprostone; this may also be a problem with dinoprostone when it is used in doses that stimulate the uterus to contract Heart or blood vessel disease (or history of) or High blood pressure (or history of) or Low blood pressure (history of) Dinoprostone may cause changes in heart function or blood pressure changes; two patients with a history of heart disease had heart attacks when dinoprostone was used in doses that stimulated the uterus to contract Kidney disease (or history of) or Liver disease (or history of) The body may not remove dinoprostone from the blood stream at the usual rate, which may make the dinoprostone work longer or cause an increased chance of side effects, especially when dinoprostone is used in doses that stimulate the uterus to contract Problems during delivery, history of or Surgery of uterus (history of) or Unusual vaginal bleeding There is an increased risk of problems occurring with dinoprostone when it is used in doses that stimulate the uterus to contract Proper Use of dinoprostone After dinoprostone is given, you will need to lie down for 10 minutes to 2 hours so that the medicine can be absorbed. The length of time you must remain lying down will depend on what form of the medicine you are using. Dosing The dose of dinoprostone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dinoprostone. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For cervical dosage form (gel): To thin and widen the opening of the cervix just before labor: Adults and teenagers Your doctor will insert 0.5 milligram (mg) (one application) of dinoprostone into the canal of your cervix. You should remain lying on your back for at least ten to thirty minutes after it has been applied. For vaginal dosage form (gel): To cause the uterus to contract for labor: Adults and teenagers Your doctor will insert 1 milligram (mg) (one applicatorful) of dinoprostone into your vagina. You should remain lying on your back for at least thirty minutes after it has been applied. You may need another dose of 1 to 2 mg six hours after the first dose. For vaginal dosage form (suppositories): To cause the uterus to contract to abort a pregnancy: Adults and teenagers Your doctor will insert 20 milligrams (mg) (one suppository) into your vagina every three to five hours as needed. You should remain lying on your back for at least ten minutes after it has been inserted. For vaginal dosage form (system): To thin and widen the opening of the cervix just before labor: Adults and teenagers Your doctor will insert 10 milligrams (mg) (one system) into your vagina. You should remain lying on your back for at least two hours after it has been inserted. dinoprostone Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common or rare Fast or slow heartbeat hives increased pain of the uterus pale, cool, blotchy skin on arms or legs pressing or painful feeling in chest shortness of breath swelling of face, inside the nose, and eyelids tightness in chest trouble in breathing weak or absent pulse in arms or legs wheezing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach cramps diarrhea fever nausea vomiting Less common or rare Chills or shivering constipation flushing headache swelling of the genital area (vulva) tender or mildly bloated abdomen or stomach This procedure may still result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if any of the following side effects occur: Chills or shivering (continuing) fever (continuing) foul-smelling vaginal discharge pain in lower abdomen unusual increase in bleeding of the uterus Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about dinoprostone topical Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 6 Reviews Add your own review/rating Drug class: uterotonic agents Consumer resources Dinoprostone topical Dinoprostone Cervical Gel Dinoprostone Vaginal Inserts Dinoprostone Vaginal Suppositories Other brands: Cervidil , Prostin E2 , Prepidil Professional resources Dinoprostone (AHFS Monograph) Dinoprostone (FDA) Dinoprostone (Wolters Kluwer) Related treatment guides Labor Induction Abortion Trophoblastic Disease} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Uterotonic agents Related Drugs Abortion misoprostol , Cytotec , oxytocin , Pitocin , mifepristone , Hemabate , Cervidil , carboprost , More... Labor Induction misoprostol , Cytotec , oxytocin , Pitocin , Cervidil , Syntocinon , Prostin E2 , dinoprostone topical , More... Trophoblastic Disease methotrexate , Trexall , Cervidil , Prostin E2 , dinoprostone topical , Cosmegen , dactinomycin , More... Dinoprostone topical Rating 6 User Reviews 3.8 /10 6 User Reviews 3.8 Rate it! Related Questions & Answers Dinoprostone - can you get it over the counter? Read more questions} } maybe
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