contemporary [500/mm:6 months: Consider treatment interruption. Serious infection: Consider withholding treatment until infection resolves. Administration Oral: Swallow capsules whole and intact; do not crush, chew, open the capsule, or sprinkle contents on food. Administer with or without food; administering with food may decrease the incidence of flushing. Administration of aspirin (nonenteric coated up to a dose of 325 mg) 30 minutes prior to dimethyl fumarate may also reduce the incidence of flushing. Storage Store at 15 C to 30 C (50 F to 86 F). Protect capsules from light and store in the original container. Drug Interactions Vaccines (Live): Dimethyl Fumarate may enhance the adverse/toxic effect of Vaccines (Live). Specifically, Dimethyl Fumarate may increase the risk of vaccinal infection. Dimethyl Fumarate may diminish the therapeutic effect of Vaccines (Live). Management: Canadian labeling for dimethyl fumarate states that live attenuated vaccine administration is not recommended during treatment. U.S. labeling does not mention this. Consider therapy modification Adverse Reactions >10%: Cardiovascular: Flushing (40%) Gastrointestinal: Abdominal pain (18%), diarrhea (14%), nausea (12%) Infection: Infection (60%) 1% to 10%: Dermatologic: Pruritus (8%), skin rash (8%), erythema (5%) Endocrine & metabolic: Albuminuria (6%) Gastrointestinal: Vomiting (9%), dyspepsia (5%) Hematologic & oncologic: Lymphocytopenia (2% to 6%) Hepatic: Increased serum AST (4%)] Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Dimethyl fumarate Rating 36 User Reviews 7.7 /10 36 User Reviews 7.7 Rate it! Drug Class Selective immunosuppressants Related Drugs selective immunosuppressants leflunomide , CellCept , mycophenolate mofetil , Arava , Tecfidera , Orencia Multiple Sclerosis Copaxone , Tecfidera , Avonex , Ampyra , Aubagio , Gilenya , Tysabri , Rebif , glatiramer , Betaseron , natalizumab , teriflunomide , fingolimod , dalfampridine , interferon beta-1a , mitoxantrone , Glatopa , Extavia , Rebif Rebidose , Avonex Pen , Novantrone , prednisone , prednisolone , More... most desirable
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