most effective amiloride and hydrochlorothiazide (Oral route) a-MIL-oh-ride hye-droe-KLOR-ide, hye-droe-klor-oh-THYE-a-zide Oral route(Tablet) May cause hyperkalemia, which is potentially fatal if uncorrected. The risk is higher in patients with renal impairment or diabetes mellitus. Monitor serum potassium levels carefully in any patient receiving therapy. . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Moduretic 5-50 Available Dosage Forms: Tablet Therapeutic Class: Diuretic, Potassium Sparing/Thiazide Combination Pharmacologic Class: Amiloride Chemical Class: Thiazide Slideshow 14 Essential Health Screenings That All Men Should Consider Uses For amiloride and hydrochlorothiazide Amiloride and hydrochlorothiazide combination is used alone or with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled . amiloride and hydrochlorothiazide is also used to treat water retention (edema) in patients with congestive heart failure . Amiloride and hydrochlorothiazide are both diuretic medicines (water pills). They reduce the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. Amiloride keeps your body from losing too much potassium when urine flow is increased . amiloride and hydrochlorothiazide is available only with your doctor's prescription . Before Using amiloride and hydrochlorothiazide In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amiloride and hydrochlorothiazide, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to amiloride and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of amiloride and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established . Geriatric Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of amiloride and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney or heart problems, which may require an adjustment in the dose for patients receiving amiloride and hydrochlorothiazide combination . Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking amiloride and hydrochlorothiazide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using amiloride and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Dofetilide Eplerenone Triamterene Using amiloride and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aceclofenac Acemetacin Acetyldigoxin Alacepril Amphetamine Amtolmetin Guacil Arginine Arsenic Trioxide Aspirin Benazepril Benzphetamine Bromfenac Bufexamac Bupropion Captopril Celecoxib Choline Salicylate Cilazapril Clonixin Cyclophosphamide Delapril Deslanoside Dexibuprofen Dexketoprofen Dextroamphetamine Diclofenac Diflunisal Digitalis Digitoxin Digoxin Dipyrone Dofetilide Droperidol Droxicam Enalaprilat Enalapril Maleate Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Flecainide Floctafenine Flufenamic Acid Flurbiprofen Fosinopril Ibuprofen Imidapril Indomethacin Ketanserin Ketoprofen Ketorolac Levomethadyl Lisdexamfetamine Lisinopril Lithium Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Methamphetamine Methotrexate Metildigoxin Moexipril Morniflumate Nabumetone Naproxen Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Ouabain Oxaprozin Oxyphenbutazone Parecoxib Pentopril Perindopril Phenylbutazone Piketoprofen Piroxicam Potassium Pranoprofen Proglumetacin Propyphenazone Proquazone Proscillaridin Quinapril Ramipril Rofecoxib Salicylic Acid Salsalate Sodium Salicylate Sotalol Spirapril Sulindac Temocapril Tenoxicam Tiaprofenic Acid Tolfenamic Acid Tolmetin Trandolapril Trimethoprim Valdecoxib Zofenopril Using amiloride and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aminolevulinic Acid Bepridil Carbamazepine Carbenoxolone Cholestyramine Ginkgo Gossypol Licorice Quinidine Topiramate Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using amiloride and hydrochlorothiazide with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use amiloride and hydrochlorothiazide, or give you special instructions about the use of food, alcohol, or tobacco. Potassium Containing Food Other Medical Problems The presence of other medical problems may affect the use of amiloride and hydrochlorothiazide. Make sure you tell your doctor if you have any other medical problems, especially: Diabetes or Hyperkalemia (high potassium in the blood) or Kidney disease (e.g., anuria or diabetic nephropathy) Should not be used in patients with these conditions . Gout or Hyperuricemia (high uric acid in the blood) or Hypochloremia (low chloride in the blood) or Hypokalemia (low potassium in the blood) or Hypomagnesemia (low magnesium in the blood) or Hyponatremia (low sodium in the blood) or Parathyroid disease or Systemic lupus erythematosus Use with caution. amiloride and hydrochlorothiazide may make these conditions worse . Heart disease or Liver disease, severe (e.g., cirrhosis or hepatic encephalopathy) or Lung disease Use with caution. May increase the chance of side effects . Proper Use of amiloride and hydrochlorothiazide In addition to the use of amiloride and hydrochlorothiazide, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet . Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well . Remember that amiloride and hydrochlorothiazide will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease . It is best to take amiloride and hydrochlorothiazide with food . Dosing The dose of amiloride and hydrochlorothiazide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of amiloride and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For hypertension or edema: Adults One tablet once a day. Your doctor may increase your dose if needed. Children Use and dose must be determined by your doctor . Missed Dose If you miss a dose of amiloride and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using amiloride and hydrochlorothiazide It is very important that your doctor check your progress at regular visits to make sure amiloride and hydrochlorothiazide is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects . Do not take other medicines unless they have been discussed with your doctor. This especially includes potassium supplements or salt substitutes containing potassium . amiloride and hydrochlorothiazide may increase the amount of potassium in your blood. Check with your doctor right away if you are having abdominal pain; confusion; difficulty breathing; irregular heartbeats; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs . amiloride and hydrochlorothiazide Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal pain confusion difficulty breathing irregular heartbeats nausea or vomiting nervousness numbness or tingling in the hands, feet, or lips shortness of breath weakness or heaviness of the legs Less common Dizziness fainting fast or slow heartbeat labored breathing tightness in the chest wheezing Rare Ankle, knee, or great toe joint pain arm, back, or jaw pain blistering, peeling, or loosening of the skin bloody or black, tarry stools bloody urine burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain, discomfort, or heaviness chills cloudy urine cold sweats coma constipation convulsions cough cracks in the skin decreased awareness or responsiveness decreased frequency or amount of urine diarrhea difficult or painful urination dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly dry mouth fever headache increase in heart rate increased blood pressure increased thirst itching joint pain, stiffness, or swelling lightheadedness loss of appetite loss of heat from the body lower back or side pain muscle pain or cramps pounding heartbeat or pulse rapid breathing red skin lesions, often with a purple center red, irritated eyes red, swollen skin scaly skin severe sleepiness severe stomach pain sore throat sores, ulcers, or white spots in the mouth or on the lips sunken eyes sweating swelling of the face, ankles, hands, fingers, or lower legs troubled breathing unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds weight gain wrinkled skin Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Drowsiness irritability mood changes pain or weakness in the hands or feet trembling weak pulse Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Rash weight loss Less common Leg ache stomach pain Rare Bad taste bloated, full feeling blurred or loss of vision changes in appetite decreased interest in sexual intercourse discouragement disturbed color perception double vision excess air or gas in the stomach or intestines feeling of constant movement of self or surroundings feeling of warmth feeling sad or empty general feeling of discomfort or illness hair loss or thinning of hair hiccups inability to have or keep an erection increased sweating increased urge to urinate during the night indigestion loss in sexual ability, desire, drive, or performance loss of bladder control loss of interest or pleasure muscle spasm night blindness overbright appearance of lights passing of gas redness of the face, neck, arms, and occasionally upper chest seeing halos around lights sensation of spinning sleepiness sleeplessness stomach fullness or discomfort stuffy nose swelling of the breasts or breast soreness in both females and males trouble concentrating trouble sleeping tunnel vision unable to sleep waking to urinate at night Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about amiloride/hydrochlorothiazide Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: potassium sparing diuretics with thiazides Consumer resources Hydrochlorothiazide and amiloride Amiloride and Hydrochlorothiazide Other brands: Moduretic 5-50 Professional resources Amiloride and Hydrochlorothiazide (FDA) Amiloride and Hydrochlorothiazide (Wolters Kluwer) Related treatment guides Heart Failure High Blood Pressure} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA WADA Class Anti-Doping Classification Manufacturer Teva Pharmaceuticals USA, Inc. 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