most department stores ribociclib (Oral route) rye-boe-SYE-klib Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Kisqali Available Dosage Forms: Tablet Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Cyclin-Dependent Kinase Inhibitor Slideshow Mammogram Memos: What You Need To Know Uses For ribociclib Ribociclib is used in combination with letrozole (postmenopausal women) in patients with hormone receptor (HR)-positive, HER-2 negative advanced or metastatic breast cancer. It belongs to the group of medicines called antineoplastics. Ribociclib interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. ribociclib is available only with your doctor's prescription. Before Using ribociclib In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ribociclib, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to ribociclib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of ribociclib in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ribociclib in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking ribociclib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using ribociclib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Cisapride Dronedarone Fluconazole Ketoconazole Mesoridazine Piperaquine Posaconazole Saquinavir Sparfloxacin Terfenadine Thioridazine Ziprasidone Using ribociclib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alfentanil Alfuzosin Amiodarone Amitriptyline Anagrelide Apomorphine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Asenapine Astemizole Atazanavir Azithromycin Bedaquiline Boceprevir Buserelin Carbamazepine Chloroquine Chlorpromazine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Cobicistat Conivaptan Crizotinib Cyclobenzaprine Cyclosporine Dabrafenib Dasatinib Degarelix Delamanid Desipramine Deslorelin Dihydroergotamine Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Droperidol Ebastine Efavirenz Enzalutamide Ergotamine Eribulin Erythromycin Escitalopram Everolimus Famotidine Felbamate Fentanyl Fingolimod Flecainide Flibanserin Fluoxetine Formoterol Foscarnet Fosphenytoin Galantamine Gatifloxacin Gemifloxacin Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Idelalisib Iloperidone Imipramine Indinavir Itraconazole Ivabradine Lapatinib Leuprolide Levofloxacin Lopinavir Lumacaftor Lumefantrine Mefloquine Methadone Methotrimeprazine Metronidazole Midazolam Mifepristone Mitotane Mizolastine Moricizine Moxifloxacin Nafarelin Nefazodone Nelfinavir Nilotinib Norfloxacin Octreotide Ofloxacin Olanzapine Ondansetron Oxycodone Paliperidone Panobinostat Papaverine Paroxetine Pasireotide Pazopanib Pentamidine Perphenazine Phenytoin Pimavanserin Pimozide Pipamperone Pitolisant Probucol Procainamide Prochlorperazine Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Ranolazine Rifampin Risperidone Ritonavir Sertindole Sevoflurane Sirolimus Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol St John's Wort Sultopride Sunitinib Tacrolimus Tamoxifen Telaprevir Telavancin Telithromycin Temsirolimus Tetrabenazine Tizanidine Tolterodine Toremifene Trazodone Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vinflunine Voriconazole Vorinostat Zotepine Zuclopenthixol Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using ribociclib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ribociclib, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Pomegranate Pomegranate Juice Other Medical Problems The presence of other medical problems may affect the use of ribociclib. Make sure you tell your doctor if you have any other medical problems, especially: Angina (severe chest pain), unstable or Congestive heart failure or Electrolyte imbalance or Heart attack, recent or Heart rhythm problems (eg, long QT syndrome, slow heartbeat) May cause side effects to become worse. Liver disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of ribociclib Medicines used to treat cancer are very strong and can have many side effects. Before receiving ribociclib, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment. Take ribociclib exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. ribociclib comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions. Ribociclib is taken together with letrozole. It is important that you take both medicines at the same time each day, preferably in the morning . Follow your doctor's instructions on when to take these medicines. Swallow the tablet whole. Do not crush, break, or chew it. You may take ribociclib with or without food. Do not eat grapefruit or pomegranate, or drink grapefruit or pomegranate juice while you are using ribociclib. Dosing The dose of ribociclib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of ribociclib. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For metastatic breast cancer with letrozole: Adults 600 milligrams (mg) (three 200 mg tablets) taken as a single dose, once a day for 21 consecutive days, followed by 7 days without medicine. Your doctor may adjust your dose as needed and tolerated. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of ribociclib, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in its original package. Precautions While Using ribociclib It is very important that your doctor check your progress at regular visits to make sure ribociclib is working properly. Blood tests may be needed to check for unwanted effects. Using ribociclib while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using ribociclib to make sure you are not pregnant. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 3 weeks after your last dose. If you think you have become pregnant while using the medicine, tell your doctor right away. If you plan to have children, talk with your doctor before using ribociclib. Some men using ribociclib have become infertile (unable to have children). Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. Ribociclib can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. ribociclib Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Black, tarry, stools bladder pain bloating or swelling of the face, arms, hands, lower legs, or feet bloody or cloudy urine chills cough difficult or labored breathing difficult, burning, or painful urination fever frequent urge to urinate lower back or side pain pale skin rapid weight gain sore throat tightness in the chest tingling of the hands or feet troubled breathing with exertion ulcers, sores, or white spots in the mouth unusual bleeding or bruising unusual tiredness or weakness unusual weight gain or loss Less common Fainting irregular heartbeat recurrent Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain back pain decreased appetite diarrhea difficulty having a bowel movement (stool) hair loss or thinning of the hair headache nausea rash or itching skin swelling or inflammation of the mouth trouble sleeping vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. 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Next Side Effects Print this page Add to My Med List More about ribociclib Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: CDK 4/6 inhibitors Consumer resources Ribociclib Other brands: Kisqali Professional resources Ribociclib Succinate (AHFS Monograph) Related treatment guides Breast Cancer, Metastatic Breast Cancer} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class CDK 4 / 6 inhibitors Related Drugs Breast Cancer, Metastatic anastrozole , tamoxifen , letrozole , Arimidex , Femara , Xeloda , Taxol , capecitabine , Ibrance , Herceptin , Faslodex , Taxotere , More... Breast Cancer methotrexate , anastrozole , tamoxifen , letrozole , Arimidex , Femara , exemestane , fluorouracil , Xeloda , Taxol , capecitabine , Aromasin , More... Ribociclib Rating No Reviews - Be the first! No Reviews - Be the first! 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