worthwhile Rifamate (Oral) Generic Name: rifampin and isoniazid (Oral route) rif-AM-pin, eye-soe-NYE-a-zid Oral route(Capsule) Severe and sometimes fatal hepatitis has been reported with isoniazid therapy and may occur even after many months of treatment. The risk for hepatitis generally increases with advancing age and alcohol use. Monthly clinical evaluation and liver function tests should be performed. Instruct patients to report immediately any of the prodromal symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid should be discontinued promptly. If isoniazid must be reinstituted, it should be reinstituted only after symptoms and laboratory abnormalities have cleared. The drug should be restarted in very small and gradually increasing doses and should be withdrawn immediately if there is any indication of recurrent liver involvement. Treatment should be deferred in persons with acute hepatic diseases . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. IsonaRif Rifamate Available Dosage Forms: Capsule Tablet Therapeutic Class: Antitubercular Combination Chemical Class: Rifamycin Slideshow Diabetic Nerve Pain: Symptoms And Treatment Uses For Rifamate Rifampin and isoniazid is a combination antibiotic and anti-infective medicine. This combination medication is used to treat tuberculosis (TB). It may be taken alone or with one or more other medicines for TB. To help clear up your tuberculosis (TB) infection completely, you must keep taking this medicine for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses. Rifampin and isoniazid combination is available only with your doctor's prescription. Before Using Rifamate In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Rifampin and isoniazid combination is not recommended for use in children. Geriatric Liver problems are more likely to occur in patients over 50 years of age who are taking isoniazid-containing medicines. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Artemether Atazanavir Boceprevir Cobicistat Daclatasvir Darunavir Dasabuvir Delamanid Elbasvir Elvitegravir Fosamprenavir Grazoprevir Isavuconazonium Lopinavir Lurasidone Maraviroc Nelfinavir Ombitasvir Paritaprevir Praziquantel Ranolazine Rilpivirine Ritonavir Saquinavir Telaprevir Tipranavir Voriconazole Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Acetaminophen Afatinib Amiodarone Amprenavir Apixaban Apremilast Aprepitant Aripiprazole Atovaquone Axitinib Bedaquiline Bosutinib Brexpiprazole Brigatinib Brivaracetam Bupropion Cabozantinib Carbamazepine Cariprazine Ceritinib Cholera Vaccine, Live Clozapine Cobimetinib Crizotinib Cyclosporine Dabigatran Etexilate Dasatinib Deferasirox Deflazacort Delavirdine Desogestrel Dienogest Digoxin Dolutegravir Domperidone Donepezil Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Drospirenone Edoxaban Efavirenz Eliglustat Eluxadoline Enzalutamide Erlotinib Estradiol Ethinyl Estradiol Ethionamide Ethynodiol Etonogestrel Etravirine Everolimus Exemestane Fentanyl Fosaprepitant Fosphenytoin Gefitinib Gestodene Glimepiride Ibrutinib Idelalisib Ifosfamide Imatinib Indinavir Irinotecan Irinotecan Liposome Isoniazid Itraconazole Ivabradine Ivacaftor Ixabepilone Ixazomib Ketoconazole Lamotrigine Lapatinib Ledipasvir Levodopa Levonorgestrel Linagliptin Lorcainide Macitentan Manidipine Mestranol Methadone Midostaurin Mifepristone Mycophenolate Mofetil Mycophenolic Acid Naloxegol Netupitant Nevirapine Nifedipine Nilotinib Nimodipine Nintedanib Norethindrone Norgestimate Norgestrel Olaparib Osimertinib Palbociclib Panobinostat Pazopanib Perampanel Phenytoin Piperaquine Pitavastatin Pixantrone Ponatinib Posaconazole Pyrazinamide Quetiapine Quinine Regorafenib Ribociclib Rifampin Rivaroxaban Roflumilast Rolapitant Romidepsin Simeprevir Sirolimus Sofosbuvir Sonidegib Sorafenib Sunitinib Tacrolimus Tasimelteon Tegafur Telithromycin Temsirolimus Tenofovir Alafenamide Thiotepa Ticagrelor Tofacitinib Tolvaptan Trabectedin Ulipristal Valbenazine Vandetanib Velpatasvir Vemurafenib Venetoclax Vilazodone Vincristine Vincristine Sulfate Liposome Vinflunine Vorapaxar Vortioxetine Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acetyldigoxin Aliskiren Aminosalicylic Acid Anisindione Aripiprazole Lauroxil Atorvastatin Betamethasone Bexarotene Bosentan Buspirone Carbamazepine Carvedilol Caspofungin Chloramphenicol Chlorpropamide Citalopram Clarithromycin Clofibrate Cortisone Dexamethasone Diazepam Dicumarol Diltiazem Disopyramide Disulfiram Doxycycline Eltrombopag Enalaprilat Enalapril Maleate Enflurane Etoricoxib Fesoterodine Fluconazole Fludrocortisone Fosphenytoin Gliclazide Glyburide Haloperidol Isradipine Levomethadyl Levothyroxine Linezolid Losartan Mefloquine Meperidine Metformin Methylprednisolone Metoprolol Morphine Morphine Sulfate Liposome Moxifloxacin Nisoldipine Ospemifene Oxcarbazepine Oxycodone Phenprocoumon Phenytoin Pioglitazone Pirmenol Prednisolone Prednisone Propafenone Raltegravir Repaglinide Rofecoxib Rosiglitazone Sertraline Simvastatin Tadalafil Tamoxifen Theophylline Tocainide Triazolam Trimetrexate Valproic Acid Warfarin Zaleplon Zidovudine Zolpidem Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Ethanol Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. food Tyramine Containing Food Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse (or history of) or Liver disease There may be an increased chance of getting hepatitis if you take this medicine and drink alcohol daily Convulsive disorders such as seizures or epilepsy Rifampin and isoniazid combination may increase the frequency of seizures (convulsions) in some patients Kidney disease (severe) There may be an increased chance of side effects in patients with severe kidney disease Proper Use of rifampin and isoniazid This section provides information on the proper use of a number of products that contain rifampin and isoniazid. It may not be specific to Rifamate. Please read with care. If this medicine upsets your stomach, take it with food. Antacids may also help. However, do not take aluminum-containing antacids within 1 hour of the time you take rifampin and isoniazid combination. They may keep this medicine from working properly. To help clear up your tuberculosis (TB) completely, it is very important that you keep taking this medicine for the full time of treatment, even if you begin to feel better after a few weeks. You may have to take it every day for as long as 1 to 2 years or more. It is important that you do not miss any doses. Your doctor may also want you to take pyridoxine (e.g., Hexa-Betalin, vitamin B 6) every day to help prevent or lessen some of the side effects of isoniazid. If it is needed, it is very important to take pyridoxine every day along with this medicine. Do not miss any doses. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For the oral dosage form (capsules): For the treatment of tuberculosis: Adults and older children 600 milligrams (mg) of rifampin and 300 mg of isoniazid once a day. Children This combination medicine is not recommended for use in children. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using Rifamate It is very important that your doctor check your progress at regular visits. In addition, you should check with your doctor immediately if blurred vision or loss of vision, with or without eye pain, occurs during treatment. He or she may want you to have your eyes checked by an ophthalmologist (eye doctor). If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor. Oral contraceptives (birth control pills) containing estrogen may not work properly if you take them while you are taking rifampin and isoniazid combination. Unplanned pregnancies may occur. You should use a different means of birth control while you are taking this medicine. If you have any questions about this, check with your health care professional. Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking this medicine. Also, the regular use of alcohol may keep this medicine from working properly. Therefore, you should strictly limit the amount of alcoholic beverages you drink while you are taking this medicine. Certain foods such as cheese (Swiss or Cheshire) or fish (tuna, skipjack, or Sardinella) may rarely cause reactions in some patients taking isoniazid-containing medicines. Check with your doctor if redness or itching of the skin, hot feeling, fast or pounding heartbeat, sweating, chills or clammy feeling, headache, or lightheadedness occurs after eating these foods while you are taking this medicine. This medicine will cause the urine, stool, saliva, sputum, sweat, and tears to turn reddish-orange to reddish-brown. This is to be expected while you are taking this medicine. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. Therefore, it is best not to wear soft contact lenses while taking this medicine. This condition will return to normal once you stop taking this medicine. Hard contact lenses are not discolored by this medicine. If you have any questions about this, check with your doctor. If this medicine causes you to feel very tired or very weak; or causes clumsiness; unsteadiness; a loss of appetite; nausea; numbness, tingling, burning, or pain in the hands and feet; or vomiting, stop taking it and check with your doctor immediately. These may be early warning symptoms of more serious liver or nerve problems that could develop later. Rifampin and isoniazid combination may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. Rifamate Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Clumsiness or unsteadiness dark urine loss of appetite nausea and vomiting numbness, tingling, burning, or pain in hands and feet unusual tiredness or weakness yellow eyes or skin Less common Chills difficult breathing dizziness fever headache itching muscle and bone pain shivering skin rash and redness Rare Bloody or cloudy urine blurred vision or loss of vision, with or without eye pain convulsions (seizures) depression greatly decreased frequency of urination or amount of urine mood or mental changes sore throat unusual bleeding or bruising Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea stomach pain or upset Less common Sore mouth or tongue This medicine commonly causes reddish-orange to reddish-brown discoloration of urine, stool, saliva, sputum, sweat, and tears. This side effect does not usually require medical attention. Dark urine and yellowing of the eyes or skin (signs of liver problems) are more likely to occur in patients 50 years of age and older. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 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Next Side Effects Print this page Add to My Med List More about Rifamate (isoniazid / rifampin) Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: antituberculosis combinations Consumer resources Rifamate Other brands: IsonaRif Professional resources Rifamate (FDA) Related treatment guides Tuberculosis, Active} Drug Status Rx Availability Prescription only N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Sanofi-Aventis U.S. LLC Drug Class Antituberculosis combinations Related Drugs Tuberculosis, Active ciprofloxacin , Levaquin , levofloxacin , rifampin , moxifloxacin , Avelox , isoniazid , ethambutol , amikacin , gatifloxacin , streptomycin , pyrazinamide , Floxin , Rifadin , Amikin , Myambutol , cycloserine , Tequin , isoniazid / pyrazinamide / rifampin , rifapentine , kanamycin , ethionamide , More... Rifamate Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Rifamate Images Rifamate 150 mg / 300 mg (RIFAMATE RIFAMATE) View larger images Help and Support Looking for answers? Ask a question or go join the Rifamate support group to connect with others who have similar interests.} } to your doorstep
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