struggle through Duavee (Oral) Generic Name: conjugated estrogens and bazedoxifene (Oral route) ba-ze-DOX-i-feen AS-e-tate, KON-joo-gay-ted ES-troe-jenz Oral route(Tablet) Women taking bazedoxifene/conjugated estrogens should not take additional estrogens. There is an increased risk of endometrial cancer in women with a uterus that use unopposed estrogens. Estrogen therapy should not be used for the prevention of cardiovascular disease or dementia. The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) with daily conjugated estrogens therapy compared with placebo. The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older with daily conjugated estrogens therapy compared with placebo . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Duavee Available Dosage Forms: Tablet Pharmacologic Class: Bazedoxifene Slideshow Osteoporosis: A Battle For Your Bones Uses For Duavee Bazedoxifene and conjugated estrogens combination is used to treat moderate to severe hot flashes and other symptoms of menopause in women with a uterus (womb). This medicine is also used to prevent osteoporosis (thinning of the bones) after menopause. This medicine is available only with your doctor's prescription. Before Using Duavee In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Use of Duavee is not indicated in children. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Duavee in the elderly. However, elderly patients are more likely to have certain unwanted effects (eg, dementia), which may require caution in patients receiving this medicine. However, use of Duavee is not recommended in women older than 75 years of age. Pregnancy Pregnancy Category Explanation All Trimesters X Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit. Breast Feeding Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Bupropion Dasabuvir Donepezil Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Clarithromycin Etoricoxib Ginseng Ketoconazole Levothyroxine Licorice Tipranavir Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Abnormal or unusual vaginal bleeding or Blood clots (eg, deep vein thrombosis, pulmonary embolism), active or history of or Breast cancer, known or suspected, or a history of or Heart attack, history of or Liver disease or Protein C, protein S, or other known blood clotting disorders or Stroke, history of or Tumors (estrogen-dependent), known or suspected Should not be used in patients with these conditions. Asthma or Diabetes or Edema (fluid retention or body swelling) or Endometriosis or Epilepsy (seizures) or Gallbladder disease or Hereditary angioedema (swelling of the face, lips, tongue, or throat) or Hypercalcemia (high calcium in the blood) or Hypocalcemia (low calcium in the blood) or Hypothyroidism (an underactive thyroid) or Jaundice during pregnancy or from using hormonal therapy in the past or Liver tumors or Migraine headache or Porphyria (an enzyme problem) or Systemic lupus erythematosus (SLE) Use with caution. May make these conditions worse. Heart disease or Hypercholesterolemia (high cholesterol or fats in the blood) or Hypertension (high blood pressure) or Hypertriglyceridemia (high triglycerides or fats in the blood) or Obesity, or history of or Prolonged periods of immobilization Use with caution. These conditions may increase risk for more serious side effects. Kidney disease Use is not recommended. This medicine has not been studied in patients with this condition. Proper Use of Duavee It is very important that you use this medicine only as directed by your doctor . Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects. This medicine comes with a patient information leaflet. Read and follow the instructions in the leaflet carefully. Ask your doctor if you have any questions. Swallow the tablet whole. Do not crush, break, or chew it. You may take this medicine with or without food. Your doctor may also want you to take vitamin D and calcium supplements while taking this medicine. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For treatment of menopause symptoms and prevention of osteoporosis: Adults One tablet once a day. Each tablet contains 20 milligrams (mg) of bazedoxifene and 0.45 mg of conjugated estrogens.s Children Use is not recommended. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep your medicine in the original package until you are ready to use it. Do not place the tablets in pill boxes or pill organizers. After opening the foil pouch, use the medicine within 60 days. Precautions While Using Duavee It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. Pelvic exam, breast exam, and mammogram (breast x-ray) may be needed to check for unwanted effects, unless your doctor tells you otherwise. Be sure to keep all appointments. It is unlikely that a postmenopausal woman may become pregnant. But, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. Using this medicine may increase your risk for having blood clots, strokes, or heart attacks. This risk may continue even after you stop using the medicine. Your risk for these serious problems is even greater if you have high blood pressure, high cholesterol in your blood, diabetes or are overweight or smoke cigarettes. Contact your doctor immediately if you experience chest pain, confusion, difficulty speaking, double vision, headaches, an inability to move arms, legs or facial muscle, or an inability to speak. Using this medicine may increase your risk of endometrial cancer, breast cancer, or uterine cancer. Talk with your doctor about this risk. Check with your doctor immediately if your experience abnormal vaginal bleeding. Using this medicine may increase your risk of dementia, especially in women 65 years of age and older. Check with your doctor immediately if severe headache or sudden loss of vision or any other change in vision occurs while you are using this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery or if you need to stay in bed for an extended time. This medicine may affect the results of certain medical tests. Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. Duavee Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Incidence not known Acid or sour stomach anxiety backache belching bloating change in vaginal discharge chest pain chills clear or bloody discharge from the nipple confusion constipation cough darkened urine difficulty with speaking dimpling of the breast skin dizziness or lightheadedness double vision fainting fast heartbeat fever full or bloated feeling or pressure in the stomach headache heartburn inability to move the arms, legs, or facial muscles inability to speak indigestion inverted nipple loss of appetite lump in the breast or under the arm nausea pain or feeling of pressure in the pelvis pain, redness, or swelling in the arm or leg pains in the stomach, side, or abdomen, possibly radiating to the back persistent crusting or scaling of the nipple redness or swelling of the breast slow speech sore on the skin of the breast that does not heal stomach discomfort, upset, or pain sudden shortness of breath or troubled breathing swelling of the abdominal or stomach area vaginal bleeding vomiting yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea muscle spasm throat pain upper abdominal or stomach pain Less common Neck pain Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about Duavee (bazedoxifene / conjugated estrogens) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 9 Reviews Add your own review/rating Drug class: sex hormone combinations Consumer resources Duavee Professional resources Duavee (FDA) Bazedoxifene Acetate (AHFS Monograph) Related treatment guides Osteoporosis Postmenopausal Symptoms Hot Flashes Prevention of Osteoporosis} Drug Status Rx Availability Prescription only X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Pfizer Inc. Drug Class Sex hormone combinations Related Drugs Postmenopausal Symptoms estradiol , Premarin , Estrace , Prempro , conjugated estrogens topical , More... Hot Flashes paroxetine , Brisdelle , Estratest , esterified estrogens / methyltestosterone , Covaryx , EEMT , More... Osteoporosis hydrochlorothiazide , alendronate , calcium carbonate , estradiol , Fosamax , More... Prevention of Osteoporosis alendronate , Fosamax , Evista , raloxifene , Boniva , Actonel , More... Duavee Rating 9 User Reviews 8.5 /10 9 User Reviews 8.5 Rate it! Related Questions & Answers Why is Duavee only for people who have not had a hysterectomy? Duavee - how do you feel about taking this medication? Does it work? Do you feel safe taking it? I have anxiety and panic attacks. I am 61 years old and my doctor put me on duavee. Does it cause a? Read more questions} } years to come
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