expecting axitinib (Oral route) ax-I-ti-nib Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Inlyta Available Dosage Forms: Tablet Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Tyrosine Kinase Inhibitor Slideshow Checkpoint Inhibitors & Advanced Cancers: A Healthcare Professional's Guide Uses For axitinib Axitinib treats late stage kidney cancer in patients who have received at least one cancer treatment that did not work. It is an antineoplastic agent (cancer medicine). axitinib is available only with your doctor's prescription. Before Using axitinib In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For axitinib, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to axitinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of axitinib in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of axitinib in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking axitinib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using axitinib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atazanavir Boceprevir Bosentan Carbamazepine Clarithromycin Conivaptan Efavirenz Enzalutamide Etravirine Fosphenytoin Indinavir Itraconazole Ketoconazole Lopinavir Lumacaftor Mitotane Modafinil Nafcillin Nefazodone Nelfinavir Netupitant Phenobarbital Phenytoin Posaconazole Primidone Rifampin Ritonavir Saquinavir St John's Wort Telaprevir Telithromycin Voriconazole Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using axitinib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use axitinib, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of axitinib. Make sure you tell your doctor if you have any other medical problems, especially: Bleeding problems or Heart failure, history of or Hypertension (high blood pressure) or Stomach or bowel fistula (a hole or opening) or Thyroid problems Use with caution. May make these conditions worse. Blood clotting problems, history of or Deep vein thrombosis (blood clot in the leg), history of or Heart attack, history of or Pulmonary embolism (blood clot in the lung), history of or Retinal artery or vein occlusion (blood clot in the eye), history of or Transient ischemic attack, history of Use with caution. May make side effects become worse. Liver disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of axitinib Take axitinib exactly as directed by your doctor , even if you feel well. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. axitinib comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions. You may take axitinib with or without food. Swallow the tablet whole with a glass of water. Do not break, crush, or chew it. Do not eat grapefruit or drink grapefruit juice while you are using axitinib. Grapefruit and grapefruit juice may change the amount that is absorbed in the body. Dosing The dose of axitinib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of axitinib. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For kidney cancer: Adults At first, 5 milligrams (mg) two times a day, taken 12 hours apart. Your doctor may adjust your dose as needed and tolerated. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of axitinib, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you vomit after taking your medicine, call your doctor or pharmacist for instructions. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using axitinib If you will be taking axitinib for a long time, it is very important that your doctor check you at regular visits for any unwanted effects caused by axitinib. Blood and urine tests may be needed to check for unwanted effects. Using axitinib while you are pregnant can harm your unborn baby. axitinib may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Use an effective form of birth control to keep from getting pregnant. Men should use condoms during sexual intercourse. If you think you have become pregnant or your partner has become pregnant while using axitinib, tell your doctor right away. Your blood pressure should be checked regularly during therapy with axitinib. The symptoms of high blood pressure are blurred vision, dizziness, nervousness, headache, pounding in the ears, or a slow or fast heartbeat. axitinib may cause serious heart and blood vessel problems. Call your doctor right away if you have chest pain or discomfort, numbness or weakness on one side of your body, pain or discomfort in your arms, jaw, back or neck, shortness of breath, trouble talking, or vision changes. If you are rapidly gaining weight, having shortness of breath, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or your body keeping too much water. Check with your doctor right away if you have severe stomach burning, cramps, or pains, bloody or black, tarry stools, trouble breathing, heartburn, indigestion, nausea, or vomiting of material that looks like coffee grounds. These could be symptoms of a serious bowel problem. axitinib may increase your chance of bleeding and cause a delay in wound healing. To help with this problem, stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Make sure any doctor who treats you knows that you are using axitinib. You may need to stop using axitinib at least 24 hours before surgery. axitinib may increase your chance of having a brain condition called reversible posterior leukoencephalopathy syndrome (RPLS). Check with your doctor right away if you have headaches, seizures, extreme drowsiness, confusion, or problems with vision while you are using axitinib. axitinib may cause a serious skin problem called hand-foot syndrome. Check with your doctor right away if you have a skin rash or any redness, pain, swelling, or blisters on the palms of your hands or the soles of your feet. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. axitinib Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal or stomach pain bleeding gums bloody nose blurred vision cloudy urine confusion constipation coughing up blood decreased urination depressed mood difficult or labored breathing difficulty with swallowing dizziness dry mouth dry skin and hair fainting feeling cold hair loss hoarseness or husky voice incoherent speech increased menstrual flow or vaginal bleeding increased urination lightheadedness loss of appetite metallic taste muscle cramps and stiffness muscle weakness nausea nervousness nosebleeds paralysis pounding in the ears rapid breathing red or black, tarry stools red or dark brown urine redness, swelling, or pain of the skin scaling of the skin on the hands and feet slow or fast heartbeat sunken eyes thirst tightness in the chest tingling of the hands and feet ulceration of the skin unusual tiredness or weakness vomiting weight gain or loss wrinkled skin Less common Anxiety bleeding from the gums or nose bleeding from the rectum bloody, black or tarry stools change in vision chest pain or discomfort extreme drowsiness eye pain heartburn inability to speak indigestion numbness or tingling in the face, arms, hands, or legs pain in the chest, groin, or legs pain or discomfort in the arms, jaw, back, or neck pain, redness, or swelling in the arm or leg pale skin ringing in the ears seizures sensitivity to heat severe headaches of sudden onset severe stomach pain, cramping, or burning slurred speech sudden loss of coordination sudden onset of slurred speech sudden shortness of breath or troubled breathing sudden vision changes sweating temporary blindness trouble sleeping trouble speaking, thinking, or walking troubled breathing with exertion uncomfortable swelling around the anus unusual bleeding or bruising vomiting of material that looks like coffee grounds weakness in the arm or leg on one side of the body Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Belching change in taste cough cracked lips decreased appetite diarrhea difficulty with moving itching skin or rash joint pain lack or loss of strength loss of taste muscle aches or pain pain in the arms or legs sore throat sores, ulcers, or white spots on the lips, tongue, or inside the mouth stomach discomfort or upset swelling or inflammation of the mouth swollen joints upper stomach pain voice changes Less common Burning sensation of the tongue continuous ringing or buzzing or other unexplained noise in the ears flushing or redness of the skin hearing loss thinning of the hair unusually warm skin Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about axitinib Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: multikinase inhibitors Consumer resources Axitinib Other brands: Inlyta Professional resources Axitinib (AHFS Monograph) Axitinib (Wolters Kluwer) Related treatment guides Renal Cell Carcinoma} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Multikinase inhibitors VEGF / VEGFR inhibitors Related Drugs Renal Cell Carcinoma Avastin , Opdivo , nivolumab , Nexavar , Afinitor , Sutent , bevacizumab , Votrient , sorafenib , everolimus , pazopanib , Lenvima , Cabometyx , sunitinib , Proleukin , lenvatinib , Inlyta , cabozantinib , Torisel , temsirolimus , aldesleukin , More... Axitinib Rating No Reviews - Be the first! 6.0 /10 No Reviews - Be the first! 6.0 Rate it! Related Questions & Answers Axitinib - I am having problems eating is anything you can suggest? Read more questions} } you actually
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