collect Signifor (Subcutaneous) Generic Name: pasireotide (Subcutaneous route, Intramuscular route) pas-i-REE-oh-tide Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Signifor Signifor LAR Available Dosage Forms: Powder for Suspension Solution Pharmacologic Class: Somatostatin (class) Slideshow Fertility Facts: Women's Fertility Issues Explained Uses For Signifor Pasireotide injection is used to treat Cushing's disease in adults who cannot have surgery or have failed surgery. Pasireotide injection is also used for the treatment of acromegaly (a growth hormone disorder) in patients who cannot be treated with surgery. This medicine is available only with your doctor's prescription. Before Using Signifor In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of the pasireotide injection in the pediatric population. Safety and efficacy have not been demonstrated. Geriatric Although appropriate studies on the relationship of age to the effects of pasireotide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of pasireotide injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving pasireotide injection. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Cisapride Dronedarone Mesoridazine Pimozide Piperaquine Saquinavir Sparfloxacin Terfenadine Thioridazine Ziprasidone Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acarbose Albiglutide Alfuzosin Alogliptin Amiodarone Amitriptyline Anagrelide Apomorphine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Asenapine Astemizole Atazanavir Azithromycin Bedaquiline Buserelin Canagliflozin Chloroquine Chlorpromazine Chlorpropamide Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Crizotinib Cyclobenzaprine Dabrafenib Dapagliflozin Dasatinib Degarelix Delamanid Desipramine Deslorelin Deutetrabenazine Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Droperidol Dulaglutide Ebastine Efavirenz Empagliflozin Eribulin Erythromycin Escitalopram Exenatide Famotidine Felbamate Fingolimod Flecainide Fluconazole Fluoxetine Formoterol Foscarnet Fosphenytoin Galantamine Gatifloxacin Gemifloxacin Glimepiride Glipizide Glyburide Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Iloperidone Imipramine Insulin Insulin Aspart, Recombinant Insulin Bovine Insulin Degludec Insulin Detemir Insulin Glargine, Recombinant Insulin Glulisine Insulin Lispro, Recombinant Itraconazole Ivabradine Ketoconazole Lapatinib Leuprolide Levofloxacin Linagliptin Liraglutide Lixisenatide Lumefantrine Mefloquine Metformin Methadone Metronidazole Mifepristone Miglitol Mizolastine Moxifloxacin Nafarelin Nateglinide Nelfinavir Nilotinib Norfloxacin Octreotide Ofloxacin Olanzapine Ondansetron Paliperidone Panobinostat Paroxetine Pazopanib Pentamidine Perphenazine Pimavanserin Pioglitazone Pipamperone Pitolisant Posaconazole Pramlintide Probucol Procainamide Prochlorperazine Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Ranolazine Repaglinide Ribociclib Rilpivirine Risperidone Ritonavir Rosiglitazone Saxagliptin Sertindole Sevoflurane Sitagliptin Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol Sulpiride Sunitinib Tacrolimus Tamoxifen Telaprevir Telavancin Telithromycin Tetrabenazine Tizanidine Tolazamide Tolbutamide Tolterodine Toremifene Trazodone Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vildagliptin Vinflunine Voriconazole Vorinostat Zuclopenthixol Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Adrenal problems or Gallstones, or history of or Heart disease or Heart rhythm problem (eg, QT prolongation) Use with caution. May make these conditions worse. Angina (severe chest pain), unstable or Bradycardia (slow heartbeat), history of or Congestive heart failure, not properly controlled or Heart attack, recent or Heart block, history of or Heart rhythm problem (eg, congenital long QT prolongation) or Hypokalemia (low potassium in the blood) or Hypomagnesemia (low magnesium in the blood) May increase risk for more serious side effects. Diabetes, poorly controlled or Hyperglycemia (high blood sugar) Should be treated first before using this medicine. Liver disease, moderate Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of pasireotide This section provides information on the proper use of a number of products that contain pasireotide. It may not be specific to Signifor. Please read with care. Signifor is given as a shot under your skin, usually on the thigh or the abdomen (stomach). Signifor LAR is given as a shot into a muscle, usually on the buttocks. A nurse or other trained health professional may give you this medicine or this medicine may be given at home by patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine. This medicine should come with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Use a new needle and syringe each time you inject your medicine. You might not use all of the medicine in each ampul (glass container). Do not save an opened ampul. If the medicine in the ampul has changed color, or if you see particles in it, do not use it. Put used needles and syringes in a puncture-resistant disposable container or dispose of them as directed by your doctor. Do not reuse needles and syringes. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For injection dosage form: For treatment of Cushing's disease: Adults At first, 0.6 or 0.9 milligram (mg) injected under the skin two times a day. Your doctor will adjust your dose as needed and tolerated. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Signifor It is very important that your doctor check you closely while you are receiving this medicine. This is to make sure that this medicine is working properly. Blood tests, electrocardiogram (ECG), and gallbladder ultrasound may be needed to check your progress. This medicine may cause low levels of cortisol in the blood (hypocortisolism). Tell your doctor right away if you have confusion, weakness, loss of appetite, nausea or vomiting, lightheadedness, dizziness, or fainting. This medicine may raise your blood sugar. You should check your blood sugar more often during the first 2 to 3 months you use this medicine, and then on a regular basis. Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a slow, fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation. This medicine may cause gallstones. Check with your doctor right away if you have severe stomach pain with nausea and vomiting. Check with your doctor right away if you have more than one of these symptoms while you are using this medicine: darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Signifor Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal or stomach pain or fullness anxiety bloating or swelling of the face, arms, hands, lower legs, or feet blurred vision chills cold sweats coma confusion convulsions cool, pale skin darkening of the skin decreased urine depression diarrhea dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position dry mouth fainting flushed, dry skin fruit-like breath odor gaseous abdominal or stomach pain headache increased hunger increased thirst increased urination irregular heartbeat loss of appetite loss of consciousness muscle pain or cramps nausea or vomiting nightmares numbness or tingling in the hands, feet, or lips pounding in the ears rapid weight gain recurrent fever seizures shakiness skin rash slow or fast heartbeat slurred speech sweating tingling of the hands or feet troubled breathing unexplained weight loss unusual tiredness or weakness unusual weight gain or loss yellow eyes or skin Incidence not known Clay-colored stools constipation darkened urine dry skin and hair feeling cold fever hair loss hoarseness or husky voice indigestion itching loss of appetite muscle stiffness pains in the stomach, side, or abdomen, possibly radiating to the back unpleasant breath odor vomiting of blood weight gain Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Back pain bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site cough decreased appetite difficulty with moving feeling of constant movement of self or surroundings general feeling of discomfort or illness joint pain lack or loss of strength pain in the arms or legs pressure in the stomach sensation of spinning shivering stuffy or runny nose sweating swelling of the abdominal or stomach area swollen joints trouble sleeping upper abdominal or stomach pain Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about Signifor (pasireotide) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: somatostatin and somatostatin analogs Consumer resources Signifor Signifor (Pasireotide Extended-Release Injection) Signifor (Pasireotide Injection) Other brands: Signifor LAR Professional resources Signifor (AHFS Monograph) Signifor Injection (FDA) Related treatment guides Cushing's Syndrome} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Manufacturer Novartis Pharmaceuticals Corporation Drug Class Somatostatin and somatostatin analogs Related Drugs Cushing's Syndrome dexamethasone , Decadron , cyproheptadine , mifepristone , Dexasone , Korlym , Dexpak Taperpak , aminoglutethimide , Baycadron , LoCort , Acthrel , Dexacen-4 , Solurex , Cytadren , pasireotide , More... 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